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The map label for this gene is fruR [H]

Identifier: 218927740

GI number: 218927740

Start: 587403

End: 588413

Strand: Direct

Name: fruR [H]

Synonym: YPO0543

Alternate gene names: 218927740

Gene position: 587403-588413 (Clockwise)

Preceding gene: 218927738

Following gene: 218927742

Centisome position: 12.62

GC content: 53.12

Gene sequence:

>1011_bases
GTGAAACTGGATGAGATCGCGCGCCTTGCGGGCGTTTCGCGCACAACGGCCAGTTATGTCATTAATGGCAAAGCGAAACA
GTACCGGGTCAGCGATAAAACAGTAGATAAAGTTATGGCGGTTGTCAGGGAACATAACTATCACCCGAATGCAGTCGCGG
CAGGTTTGCGCGCGGGCAGAACCCGCTCGATCGGTTTGGTGATCCCAGATCTGGAAAATACCAGCTACACCCGTATTGCC
AATTATCTGGAGCGTCAGGCTCGTCAGCGTGGTTACCAGTTGCTGATAGCCTGTTCAGAAGACCAGCCGGATAATGAAAT
GCGCTGCGTTGAGCACCTGTTACAACGCCAGGTTGATGCGATCATTGTGTCGACGGCATTGCCGCCAGAACACCCTTTCT
ATCAGCGCTGGGCCAAAGACCCATTCCCGATCATTGCCTTAGATCGGGCGCTTGATCGTGAGCATTTTATCAGTGTGGTC
GGGGCGGATCAGGAAGATGCGCAGATGTTAGCGCAAGAACTGCGCTCCTTCCCGGCTGAATCGGTGCTTTATCTGGGGGC
GCTACCGGAGCTGTCAGTCAGTTTTCTGCGTGAGATGGGCTTTCGTGAAGCGTGGAAGGACGATCCGCGTAAAGTGGAAT
ACCTATATGCCAACAGCTATGAACGCGAAGCCGCAGGTGTGTTGTTTGCTGAATGGCTGAAAACGCACCCAATGCCACAG
GCACTGTTTACCACGTCATTCCAACTTTTACAGGGTGTTATGGACGTCACCCTAAAACAAAGTGGCCGCTTACCCTGCAA
TCTGGCCATTGCGACTTTTGGTGATAACGAGCTGTTAGATTTCCTTGAATGCCCAGTATTGGCAGTGGCACAGCGCCATC
GTGATGTTGCTGAACGGGTGCTGGAGCTGGTATTGGCCAGTCTGGATGAACCCCATAAGCCAAAACCGGGGTTAACGCGG
ATTCGCCGCAATTTATTCCGCCGTGGCACTCTAAGCCTAAGCCGCAGGTAG

Upstream 100 bases:

>100_bases
TCCTCTGGGTCGATAAGTTCGGCTGAAAAGACACAGGGATGCTGGCTCTCGGCAGAGCGCTCTGCTTTTCATCACTTTAC
TGGGTTTATAAGGGGTTAAC

Downstream 100 bases:

>100_bases
TTCACTATAACGAATCAGGGCACCCGCCCTGATTTTGATTGCTGACAAACCCCGATAACGCGATCTGAAGATGCTGAGGA
TAGGCCGGGGAGCCAAGTGT

Product: DNA-binding transcriptional regulator FruR

Products: NA

Alternate protein names: Catabolite repressor/activator [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVDKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCVEHLLQRQVDAIIVSTALPPEHPFYQRWAKDPFPIIALDRALDREHFISVV
GADQEDAQMLAQELRSFPAESVLYLGALPELSVSFLREMGFREAWKDDPRKVEYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFQLLQGVMDVTLKQSGRLPCNLAIATFGDNELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPHKPKPGLTR
IRRNLFRRGTLSLSRR

Sequences:

>Translated_336_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVDKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCVEHLLQRQVDAIIVSTALPPEHPFYQRWAKDPFPIIALDRALDREHFISVV
GADQEDAQMLAQELRSFPAESVLYLGALPELSVSFLREMGFREAWKDDPRKVEYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFQLLQGVMDVTLKQSGRLPCNLAIATFGDNELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPHKPKPGLTR
IRRNLFRRGTLSLSRR
>Mature_336_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVDKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCVEHLLQRQVDAIIVSTALPPEHPFYQRWAKDPFPIIALDRALDREHFISVV
GADQEDAQMLAQELRSFPAESVLYLGALPELSVSFLREMGFREAWKDDPRKVEYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFQLLQGVMDVTLKQSGRLPCNLAIATFGDNELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPHKPKPGLTR
IRRNLFRRGTLSLSRR

Specific function: Represses some operons but activates others. It is implicated in the regulation of a large number of operons encoding enzymes which comprise central pathways of carbon metabolism. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=334, Percent_Identity=89.5209580838323, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=27.0440251572327, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787580, Length=289, Percent_Identity=23.1833910034602, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787948, Length=308, Percent_Identity=21.7532467532468, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789068, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790369, Length=324, Percent_Identity=21.9135802469136, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790715, Length=284, Percent_Identity=24.2957746478873, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789202, Length=128, Percent_Identity=31.25, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788474, Length=279, Percent_Identity=23.6559139784946, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38171; Mature: 38171

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVDKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCVEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
IIVSTALPPEHPFYQRWAKDPFPIIALDRALDREHFISVVGADQEDAQMLAQELRSFPAE
EEEECCCCCCCHHHHHHCCCCCCEEEHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHCCHH
SVLYLGALPELSVSFLREMGFREAWKDDPRKVEYLYANSYEREAAGVLFAEWLKTHPMPQ
HHHHHCCCHHHHHHHHHHHCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFQLLQGVMDVTLKQSGRLPCNLAIATFGDNELLDFLECPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHH
LELVLASLDEPHKPKPGLTRIRRNLFRRGTLSLSRR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVDKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCVEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
IIVSTALPPEHPFYQRWAKDPFPIIALDRALDREHFISVVGADQEDAQMLAQELRSFPAE
EEEECCCCCCCHHHHHHCCCCCCEEEHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHCCHH
SVLYLGALPELSVSFLREMGFREAWKDDPRKVEYLYANSYEREAAGVLFAEWLKTHPMPQ
HHHHHCCCHHHHHHHHHHHCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFQLLQGVMDVTLKQSGRLPCNLAIATFGDNELLDFLECPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHH
LELVLASLDEPHKPKPGLTRIRRNLFRRGTLSLSRR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]