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The map label for this gene is ispH [H]

Identifier: 218927675

GI number: 218927675

Start: 508567

End: 509520

Strand: Direct

Name: ispH [H]

Synonym: YPO0477

Alternate gene names: 218927675

Gene position: 508567-509520 (Clockwise)

Preceding gene: 218927674

Following gene: 218927676

Centisome position: 10.93

GC content: 48.74

Gene sequence:

>954_bases
ATGCAGATATTGCTGGCTAATCCACGTGGCTTTTGTGCTGGCGTTGACCGGGCTATCAGTATTGTTGAACGTGCGATAGA
AATGTATGGCGCGCCAATTTATGTACGCCATGAGGTGGTACATAACCGCTATGTGGTTGAGAGCCTGTGCGAGCGCGGTG
CTATCTTCATCGAGGAAATTTCAGAGGTGCCAGATGGCTCCATTCTGATTTTCTCGGCCCATGGTGTGTCACAGGCCGTT
CGGGCAGAGGCCCGTTCACGTAATTTGACGATGCTGTTTGATGCAACCTGTCCATTGGTTACCAAAGTCCATATGGAAGT
CGCCCGTGCGAGCCGTAAGGGTAAAGAAGCTATTTTGATCGGCCATGCCGGTCATCCAGAAGTGGAAGGGACCATGGGGC
AATACAGCAACCCTAACGGGGGGATGTATTTGGTTGAATCGCCTGATGACGTTTGGCAGTTGAATGTCAAAGATGAGAAT
AATCTATGTTTTATGACGCAGACCACCTTATCGGTTGATGATACCTCTGCTGTTATCGATGCGTTGAACACGCGCTTCCC
AAAGATAGTCGGCCCACGCAAAGATGATATTTGCTATGCCACAACCAATCGGCAAGAGGCAGTACGTAATCTGGCAAATG
ATGCCGATATCGTATTGGTCGTGGGGTCGAAAAACTCCTCTAACTCTAACCGATTGGCCGAACTGGTACAGCGAATGGGT
AAGCCCGCTTATCTGATTGACTCTGCGGCAGATATTCAGGAATTTTGGTTACAGGGCGCCAAGTGTATCGGTGTTACCGC
TGGTGCATCTGCCCCTGATATTTTGGTGCAGCAAGTGATTGCACGCTTAAAAGATCTTGGTGCTGGTGAATCGATTGAAC
TCAGCGGTCGCGAAGAAAATATTGTTTTTGAAGTACCGAAAGAACTGCGTGTTGAGGTTAAACAGATCGACTGA

Upstream 100 bases:

>100_bases
GAAGAGTCTATTACTGTTGATTTTAATCACCCGTTGGCTGGGCACTCTGTCAGTTTTGAACTTGAAATACTGGAGATTGA
CCCCCAACAGGAGGTTGTCT

Downstream 100 bases:

>100_bases
TTCAGGTGTTTCTTTGTCGATCAGATAGGTGTTTACTCAATATGTATTTACTGACGAAAGCAGCCCTTTGCGGCTGCTTG
AGGTTATTGATAATGCTATT

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID

Sequences:

>Translated_317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID
>Mature_317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=317, Percent_Identity=82.6498422712934, Blast_Score=544, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 34709; Mature: 34709

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
SEVPDGSILIFSAHGVSQAVRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILI
HHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEE
GHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDENNLCFMTQTTLSVDDTSAVID
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
HHHCCCCHHCCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
KPAYLIDSAADIQEFWLQGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREEN
CCEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IVFEVPKELRVEVKQID
EEEECCHHHCEEEECCC
>Mature Secondary Structure
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
SEVPDGSILIFSAHGVSQAVRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILI
HHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEE
GHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDENNLCFMTQTTLSVDDTSAVID
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
HHHCCCCHHCCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
KPAYLIDSAADIQEFWLQGAKCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREEN
CCEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IVFEVPKELRVEVKQID
EEEECCHHHCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA