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The map label for this gene is trpR

Identifier: 218927650

GI number: 218927650

Start: 478188

End: 478565

Strand: Direct

Name: trpR

Synonym: YPO0453

Alternate gene names: 218927650

Gene position: 478188-478565 (Clockwise)

Preceding gene: 218927649

Following gene: 218927652

Centisome position: 10.28

GC content: 51.32

Gene sequence:

>378_bases
TTGACTGACGAAAAACAAGTGTCGGATTCACTTAATAGGCAGACGGCTGGGAACCCTTACTCTGCCGCTGATCCGGCATT
GTCTGCCGAAGATAATCAGCACTGGTTGAGCTTTGTCGCGCTGTTGCAAAACGCGATTACACAAGATCTTCATCTGCCTT
TACTGCAACTGATGCTAACACCTGATGAGCGAACCGCCTTGGGGACGCGTGTGCGCATTATTGAAGAGTTAATGCGCGGT
GAGCTAAGCCAGCGTGAGCTGAAAAGTCAGTTGGGTGCAGGTATTGCGACGATCACCCGTGGCTCTAATAGCTTGAAAAC
GGCCCCACCACAGCTGAAAAGCTGGCTCGAAGCCCAGTTGCTAGCCAACAAACGCTAA

Upstream 100 bases:

>100_bases
CTTTTTGCCTCTTGAAATCTAGTGAGTATAGATAACTCTATGGTATGCTTGTTGTACTAGTTAAATAGTACTTTGGGTGG
TTATCATGACAAAACAATTT

Downstream 100 bases:

>100_bases
ATGGCTGGTTTAGAGGGCGATGGGCGTTGGTAAATCTCATTGTGGAACGGCACCAGTGCCAACAAGAGGGCCTGGTGATA
GACACTGGTTCGAGTTAATT

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIEELMRG
ELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR

Sequences:

>Translated_125_residues
MTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIEELMRG
ELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR
>Mature_124_residues
TDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIEELMRGE
LSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regula

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family

Homologues:

Organism=Escherichia coli, GI1790854, Length=104, Percent_Identity=70.1923076923077, Blast_Score=125, Evalue=7e-31,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): TRPR_YERPE (P58700)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0056
- RefSeq:   NP_671023.1
- RefSeq:   NP_995001.1
- RefSeq:   YP_002345525.1
- ProteinModelPortal:   P58700
- SMR:   P58700
- IntAct:   P58700
- GeneID:   1148673
- GeneID:   1173297
- GeneID:   2765227
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0453
- KEGG:   ypk:y3726
- KEGG:   ypm:YP_3730
- HOGENOM:   HBG677773
- OMA:   ELMRGEM
- ProtClustDB:   PRK01381
- BioCyc:   YPES187410:Y3726-MONOMER
- BioCyc:   YPES214092:YPO0453-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00475
- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1270.10
- PIRSF:   PIRSF003196
- ProDom:   PD012582
- TIGRFAMs:   TIGR01321

Pfam domain/function: PF01371 Trp_repressor; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 13818; Mature: 13687

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLT
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDERTALGTRVRIIEELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQL
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
LANKR
HHCCC
>Mature Secondary Structure 
TDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLT
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDERTALGTRVRIIEELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQL
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
LANKR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430