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The map label for this gene is aidB [H]

Identifier: 218927585

GI number: 218927585

Start: 398748

End: 400391

Strand: Direct

Name: aidB [H]

Synonym: YPO0383

Alternate gene names: 218927585

Gene position: 398748-400391 (Clockwise)

Preceding gene: 218927584

Following gene: 218927589

Centisome position: 8.57

GC content: 53.16

Gene sequence:

>1644_bases
ATGGGGAAAGGTATGGATTGGCAGACTCATTTGGTTTTCAATCAGCCGGAGCCTTTGTCGAACAGTAATTTGTTTCTGTC
TGACTTGGCGTTGCGCGAAGCGGTAGTTCGGGAGCATGCGGGTTGGGATGGAGAGAATCTCTCTTTGATCGGATTACAGC
TTGGTTCGTTGGAATCACTTGAATTGGGTCGGCTGGCAAATGCCCATCCACCAGAATTATTACGTTATGATGGTGCTGGG
CAGCGCTTGGGTCAGGTGCGGTTTCACCCTGCATGGCATGTCTTAATGCAAGGCCTGATCCATCATCGGGTGCATAACCT
CCCTTGGCAGGAAGATGCGCGGAACGGCTCCTTTGTGGCCCGTGCTGCACGTTTCATCCTACATGCCCAGGTAGACGCGG
GCGCGTTATGTCCGATAACCATGACGTTTGGTGCTATCCCACTGCTACAACAGACACTTCCTCCTCTCTTTCAAAACTGG
TTATCACCGCTGCTGTCTGATCGTTATGACCCCCATTTGTCCTTAGGCAATCAGAAGCGGGGTTTACTGATTGGCATGGG
AATGACAGAGAAACAGGGCGGTTCCGATGTCTTAAGTAACACCACGCGGGCAGAGCCATTAAGCATTCGTGGGCAGGGTG
AGGTCTACCGGTTGATCGGCCACAAATGGTTTTTTTCAGTGCCACAGAGTGACGCGCATTTGGTACTGGCGCAGGCTGAG
GGCGGTTTATCCTGCTTCTTTCTGCCCAAAATACTCCCGGATGGGACCCACAACGCTATCCGATTCGAGCGTTTGAAAGA
GAAGCTCGGCAACTGCTCCAACGCCAGTAGCGAAGTGGAGTTTGATAATGCCACCGCCTGGCTATTGGGAGAGGAAGGCG
ACGGTATTCGACAAATCCTGAAGATGGGCGGTTATACCCGCTTTGATTGTGCTCTGGGGAGCCATGGGTTGATGAGGCGC
GCTTTCTCCGTCGCCTTGTATCATGCCCTACAGCGTCAGGTTTTTGGTAAGGCATTGGTAGAGCAGCCCTTGATGCGACA
AGTATTGAGCCGCATGGCATTGCGTCTGGAAGGGCACACGGCGTTACTGTTACGTTTAGCCCGTGCATGGGAGGCTTCTG
GTGAGGTTCATGAGCAAATTTTTAGCCGACTGCTGACACCCGCCGCTAAATATCGGGTGTGTGGGCAGGGGAGCGCGTTT
GTGGCAGAAGCGATGGAAGTACTCGGTGGGATCGGTTATTGCGAACAGAGTGAGTTGCCACGGCTCTATCGTGAGATGCC
GGTGAACAGCATCTGGGAAGGCTCAGGCAATATTATGTGTCTTGATGTTTTGCGAACATTACGCAAATTGCCAACTGCGG
TCGAGATGCTCCAGCAAGAGTTTTACCCGGTACGCGGGCAGAATCGGCTGTTTGACCGTGCCTGGCGGCAACTGCAACAA
CGGCTGAAGAATCCTAAAGAAGAGCAAGGGCGGGCGCTGACTCAGCAACTTTTTGACCTGTGTTGCGCTTCTCAACTACT
GCGCTTTGCATCGCCACGGTTAGCTGACGCCTGGTGCCGAATGACCTTGGATCATCGTGACCAATATATGTTGCCAGAGG
CGGTTTGTGCGCGGTTACTGGAACGTGCAACGGGCGCACATTAA

Upstream 100 bases:

>100_bases
GGTGTTTTTTCCTGTTTGTGACATACCTGCCAGCAAAAGCCTCCGCCTGTACCATACTTAATCCTGACTTATGAATATTG
GTTTTCAGGGGAGTCCCGAA

Downstream 100 bases:

>100_bases
CGCGATAGCAAACATTATCGCTACAGCAAGGCCTTAACGTTACAGCAAAACATTAGCGTTATAGCAAAACATTAACGATA
CAGCAGAGCATTGGCATACC

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MGKGMDWQTHLVFNQPEPLSNSNLFLSDLALREAVVREHAGWDGENLSLIGLQLGSLESLELGRLANAHPPELLRYDGAG
QRLGQVRFHPAWHVLMQGLIHHRVHNLPWQEDARNGSFVARAARFILHAQVDAGALCPITMTFGAIPLLQQTLPPLFQNW
LSPLLSDRYDPHLSLGNQKRGLLIGMGMTEKQGGSDVLSNTTRAEPLSIRGQGEVYRLIGHKWFFSVPQSDAHLVLAQAE
GGLSCFFLPKILPDGTHNAIRFERLKEKLGNCSNASSEVEFDNATAWLLGEEGDGIRQILKMGGYTRFDCALGSHGLMRR
AFSVALYHALQRQVFGKALVEQPLMRQVLSRMALRLEGHTALLLRLARAWEASGEVHEQIFSRLLTPAAKYRVCGQGSAF
VAEAMEVLGGIGYCEQSELPRLYREMPVNSIWEGSGNIMCLDVLRTLRKLPTAVEMLQQEFYPVRGQNRLFDRAWRQLQQ
RLKNPKEEQGRALTQQLFDLCCASQLLRFASPRLADAWCRMTLDHRDQYMLPEAVCARLLERATGAH

Sequences:

>Translated_547_residues
MGKGMDWQTHLVFNQPEPLSNSNLFLSDLALREAVVREHAGWDGENLSLIGLQLGSLESLELGRLANAHPPELLRYDGAG
QRLGQVRFHPAWHVLMQGLIHHRVHNLPWQEDARNGSFVARAARFILHAQVDAGALCPITMTFGAIPLLQQTLPPLFQNW
LSPLLSDRYDPHLSLGNQKRGLLIGMGMTEKQGGSDVLSNTTRAEPLSIRGQGEVYRLIGHKWFFSVPQSDAHLVLAQAE
GGLSCFFLPKILPDGTHNAIRFERLKEKLGNCSNASSEVEFDNATAWLLGEEGDGIRQILKMGGYTRFDCALGSHGLMRR
AFSVALYHALQRQVFGKALVEQPLMRQVLSRMALRLEGHTALLLRLARAWEASGEVHEQIFSRLLTPAAKYRVCGQGSAF
VAEAMEVLGGIGYCEQSELPRLYREMPVNSIWEGSGNIMCLDVLRTLRKLPTAVEMLQQEFYPVRGQNRLFDRAWRQLQQ
RLKNPKEEQGRALTQQLFDLCCASQLLRFASPRLADAWCRMTLDHRDQYMLPEAVCARLLERATGAH
>Mature_546_residues
GKGMDWQTHLVFNQPEPLSNSNLFLSDLALREAVVREHAGWDGENLSLIGLQLGSLESLELGRLANAHPPELLRYDGAGQ
RLGQVRFHPAWHVLMQGLIHHRVHNLPWQEDARNGSFVARAARFILHAQVDAGALCPITMTFGAIPLLQQTLPPLFQNWL
SPLLSDRYDPHLSLGNQKRGLLIGMGMTEKQGGSDVLSNTTRAEPLSIRGQGEVYRLIGHKWFFSVPQSDAHLVLAQAEG
GLSCFFLPKILPDGTHNAIRFERLKEKLGNCSNASSEVEFDNATAWLLGEEGDGIRQILKMGGYTRFDCALGSHGLMRRA
FSVALYHALQRQVFGKALVEQPLMRQVLSRMALRLEGHTALLLRLARAWEASGEVHEQIFSRLLTPAAKYRVCGQGSAFV
AEAMEVLGGIGYCEQSELPRLYREMPVNSIWEGSGNIMCLDVLRTLRKLPTAVEMLQQEFYPVRGQNRLFDRAWRQLQQR
LKNPKEEQGRALTQQLFDLCCASQLLRFASPRLADAWCRMTLDHRDQYMLPEAVCARLLERATGAH

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI187960098, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4557231, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4557233, Length=309, Percent_Identity=25.8899676375405, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4501859, Length=255, Percent_Identity=23.921568627451, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI7656849, Length=268, Percent_Identity=26.4925373134328, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082384, Length=541, Percent_Identity=69.5009242144178, Blast_Score=759, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=332, Percent_Identity=25.6024096385542, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081958, Length=272, Percent_Identity=26.8382352941176, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=468, Percent_Identity=31.8376068376068, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI86563381, Length=468, Percent_Identity=31.8376068376068, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538396, Length=291, Percent_Identity=27.8350515463918, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=294, Percent_Identity=25.1700680272109, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=273, Percent_Identity=23.4432234432234, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=273, Percent_Identity=23.4432234432234, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506239, Length=273, Percent_Identity=22.3443223443223, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355753, Length=288, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=331, Percent_Identity=22.9607250755287, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=301, Percent_Identity=24.5847176079734, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646207, Length=275, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 61421; Mature: 61289

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGMDWQTHLVFNQPEPLSNSNLFLSDLALREAVVREHAGWDGENLSLIGLQLGSLESL
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCH
ELGRLANAHPPELLRYDGAGQRLGQVRFHPAWHVLMQGLIHHRVHNLPWQEDARNGSFVA
HHHHCCCCCCCHHHEECCCCHHHCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RAARFILHAQVDAGALCPITMTFGAIPLLQQTLPPLFQNWLSPLLSDRYDPHLSLGNQKR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GLLIGMGMTEKQGGSDVLSNTTRAEPLSIRGQGEVYRLIGHKWFFSVPQSDAHLVLAQAE
CEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCHHHHHCCHHEEECCCCCCEEEEEECC
GGLSCFFLPKILPDGTHNAIRFERLKEKLGNCSNASSEVEFDNATAWLLGEEGDGIRQIL
CCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEEECCCHHHHHHH
KMGGYTRFDCALGSHGLMRRAFSVALYHALQRQVFGKALVEQPLMRQVLSRMALRLEGHT
HHCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALLLRLARAWEASGEVHEQIFSRLLTPAAKYRVCGQGSAFVAEAMEVLGGIGYCEQSELP
HHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHH
RLYREMPVNSIWEGSGNIMCLDVLRTLRKLPTAVEMLQQEFYPVRGQNRLFDRAWRQLQQ
HHHHHCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
RLKNPKEEQGRALTQQLFDLCCASQLLRFASPRLADAWCRMTLDHRDQYMLPEAVCARLL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ERATGAH
HHHCCCC
>Mature Secondary Structure 
GKGMDWQTHLVFNQPEPLSNSNLFLSDLALREAVVREHAGWDGENLSLIGLQLGSLESL
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCH
ELGRLANAHPPELLRYDGAGQRLGQVRFHPAWHVLMQGLIHHRVHNLPWQEDARNGSFVA
HHHHCCCCCCCHHHEECCCCHHHCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RAARFILHAQVDAGALCPITMTFGAIPLLQQTLPPLFQNWLSPLLSDRYDPHLSLGNQKR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GLLIGMGMTEKQGGSDVLSNTTRAEPLSIRGQGEVYRLIGHKWFFSVPQSDAHLVLAQAE
CEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCHHHHHCCHHEEECCCCCCEEEEEECC
GGLSCFFLPKILPDGTHNAIRFERLKEKLGNCSNASSEVEFDNATAWLLGEEGDGIRQIL
CCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEEECCCHHHHHHH
KMGGYTRFDCALGSHGLMRRAFSVALYHALQRQVFGKALVEQPLMRQVLSRMALRLEGHT
HHCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALLLRLARAWEASGEVHEQIFSRLLTPAAKYRVCGQGSAFVAEAMEVLGGIGYCEQSELP
HHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHHH
RLYREMPVNSIWEGSGNIMCLDVLRTLRKLPTAVEMLQQEFYPVRGQNRLFDRAWRQLQQ
HHHHHCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
RLKNPKEEQGRALTQQLFDLCCASQLLRFASPRLADAWCRMTLDHRDQYMLPEAVCARLL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ERATGAH
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]