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The map label for this gene is hflK [H]

Identifier: 218927578

GI number: 218927578

Start: 389875

End: 391134

Strand: Direct

Name: hflK [H]

Synonym: YPO0375

Alternate gene names: 218927578

Gene position: 389875-391134 (Clockwise)

Preceding gene: 218927577

Following gene: 218927579

Centisome position: 8.38

GC content: 50.32

Gene sequence:

>1260_bases
ATGGCGTGGAATCAGCCCGGTAATAACGGACAGGACCGCGATCCGTGGGGGAGCAGCAATAATAATGGCGGCAACTCTGG
CGGAAATAATAATAAAGGTGGTCGTGACCAAGGGCCGCCGGATCTGGATGATATCTTCCGTAAACTGAGCAAAAAACTGA
GTAGCCTCGGTGGCAAAGGTAGCGGAAGTGGTGGTAATGGCGCATCACATGGCCCTGGTTTCAGTGGTCGTGTTGTGGGT
ATCGCTGTTGTTGCTGTTGTGGTCATCTGGGCTGCAAGCGGTTTCTATACCATTAAAGAAGCTGAGCGTGGTGTTGTCAC
CCGTTTAGGTAAATTGAGCCACATTGTGCAGCCTGGCCTGAACTGGAAACCGACCTTTATCGATGAAGTGGTTCCGGTTA
ACGTCGAGGCCGTGCGTGAATTGGCCGCTTCTGGGGTCATGCTGACCTCCGATGAGAACGTAGTGCGCGTCGAAATGAAC
GTTCAGTATCGTGTGACTGATCCGGCCGCTTATCTGTTTAGCGTGACGAATCCGGATGACAGTCTGCGTCAGGCAACAGA
CAGCGCAGTACGTGGTGTTATTGGTAAATACACCATGGATAAAATCCTCACTGAAGGCCGTACCATCGTCCGTAGTGATA
CCCAACGTGTGCTGGAAGAAACGATTCGTCCGTACCAAATGGGGATTACGTTATTGGACGTTAACTTCCAGGCTGCTCGT
CCGCCAGAAGAAGTTAAAGCGGCATTTGATGACGCGATTGCTGCTCGTGAAAACGAACAACAATACATTCGCGAAGCAGA
AGCCTATACCAACGAAGTTCAACCACGTGCTAATGGTCAGGCGCAGCGTCTGTTAGAAGATGCTCGTGCTTATGCCGCAC
GTAAAGTGTTGGAAGCACAGGGTGAAGTCGCTGGTTTTGCTAAGTTGCTGCCAGAGTATAAAGCGGCACCGGAAATTACC
CGTGAGCGTCTGTACATCGAAACCATGGAAAAGGTCCTGGGCAAAACCAATAAAGTGCTGGCGAATGATAAAGGCAATAA
TTTGATGGTGTTGCCACTGGATCAAATGCTGCGTGGTCAAGGTGCTGCTAATAAAGTTGATGGCAACAAAGATACCAGTC
TGATTCGTTTGAATCCGGCACCCAGCAGCCAACAAACTGGTGCGAGTAATTCAAATACCAGCTCAGGCAGTGGTTCTATC
ATGGATCAGCGCCGGGTGAATGCTCAGCGTGATACTTCCACTCGCGTAGGGAGAGAATAA

Upstream 100 bases:

>100_bases
GAAGGGAATATCTGATCTTTCTTGTGAGATTAAGAGCCAGCTTCTTTGGCATGTGCTCTTGGCCTGAAGAAAACCAATCA
TAGAAGAATGGAGCTAAAAC

Downstream 100 bases:

>100_bases
CCAATGCGTAAGTCTTTTTTACTTATCGTCGTTGTGGTGTTAATCGCACTCTTCGCTTCGCTGTTTGTCGTAGAAGAAGG
TCAACGCGGAATTGTGCTGC

Product: FtsH protease regulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNNKGGRDQGPPDLDDIFRKLSKKLSSLGGKGSGSGGNGASHGPGFSGRVVG
IAVVAVVVIWAASGFYTIKEAERGVVTRLGKLSHIVQPGLNWKPTFIDEVVPVNVEAVRELAASGVMLTSDENVVRVEMN
VQYRVTDPAAYLFSVTNPDDSLRQATDSAVRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYQMGITLLDVNFQAAR
PPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRLLEDARAYAARKVLEAQGEVAGFAKLLPEYKAAPEIT
RERLYIETMEKVLGKTNKVLANDKGNNLMVLPLDQMLRGQGAANKVDGNKDTSLIRLNPAPSSQQTGASNSNTSSGSGSI
MDQRRVNAQRDTSTRVGRE

Sequences:

>Translated_419_residues
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNNKGGRDQGPPDLDDIFRKLSKKLSSLGGKGSGSGGNGASHGPGFSGRVVG
IAVVAVVVIWAASGFYTIKEAERGVVTRLGKLSHIVQPGLNWKPTFIDEVVPVNVEAVRELAASGVMLTSDENVVRVEMN
VQYRVTDPAAYLFSVTNPDDSLRQATDSAVRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYQMGITLLDVNFQAAR
PPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRLLEDARAYAARKVLEAQGEVAGFAKLLPEYKAAPEIT
RERLYIETMEKVLGKTNKVLANDKGNNLMVLPLDQMLRGQGAANKVDGNKDTSLIRLNPAPSSQQTGASNSNTSSGSGSI
MDQRRVNAQRDTSTRVGRE
>Mature_418_residues
AWNQPGNNGQDRDPWGSSNNNGGNSGGNNNKGGRDQGPPDLDDIFRKLSKKLSSLGGKGSGSGGNGASHGPGFSGRVVGI
AVVAVVVIWAASGFYTIKEAERGVVTRLGKLSHIVQPGLNWKPTFIDEVVPVNVEAVRELAASGVMLTSDENVVRVEMNV
QYRVTDPAAYLFSVTNPDDSLRQATDSAVRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYQMGITLLDVNFQAARP
PEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRLLEDARAYAARKVLEAQGEVAGFAKLLPEYKAAPEITR
ERLYIETMEKVLGKTNKVLANDKGNNLMVLPLDQMLRGQGAANKVDGNKDTSLIRLNPAPSSQQTGASNSNTSSGSGSIM
DQRRVNAQRDTSTRVGRE

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=420, Percent_Identity=78.5714285714286, Blast_Score=590, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 45286; Mature: 45155

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNNKGGRDQGPPDLDDIFRKLSKKLSSLGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
SGSGGNGASHGPGFSGRVVGIAVVAVVVIWAASGFYTIKEAERGVVTRLGKLSHIVQPGL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
NWKPTFIDEVVPVNVEAVRELAASGVMLTSDENVVRVEMNVQYRVTDPAAYLFSVTNPDD
CCCCCHHHCCCCCCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCEEEEEECCCCH
SLRQATDSAVRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYQMGITLLDVNFQAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCEEEEEECCCCCC
PPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRLLEDARAYAARKVLEAQ
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GEVAGFAKLLPEYKAAPEITRERLYIETMEKVLGKTNKVLANDKGNNLMVLPLDQMLRGQ
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHHHCCC
GAANKVDGNKDTSLIRLNPAPSSQQTGASNSNTSSGSGSIMDQRRVNAQRDTSTRVGRE
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWNQPGNNGQDRDPWGSSNNNGGNSGGNNNKGGRDQGPPDLDDIFRKLSKKLSSLGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
SGSGGNGASHGPGFSGRVVGIAVVAVVVIWAASGFYTIKEAERGVVTRLGKLSHIVQPGL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCC
NWKPTFIDEVVPVNVEAVRELAASGVMLTSDENVVRVEMNVQYRVTDPAAYLFSVTNPDD
CCCCCHHHCCCCCCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCEEEEEECCCCH
SLRQATDSAVRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYQMGITLLDVNFQAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHCEEEEEECCCCCC
PPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRLLEDARAYAARKVLEAQ
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GEVAGFAKLLPEYKAAPEITRERLYIETMEKVLGKTNKVLANDKGNNLMVLPLDQMLRGQ
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHHHCCC
GAANKVDGNKDTSLIRLNPAPSSQQTGASNSNTSSGSGSIMDQRRVNAQRDTSTRVGRE
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]