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The map label for this gene is gltP [H]

Identifier: 218927459

GI number: 218927459

Start: 253545

End: 254861

Strand: Direct

Name: gltP [H]

Synonym: YPO0254

Alternate gene names: 218927459

Gene position: 253545-254861 (Clockwise)

Preceding gene: 218927453

Following gene: 218927462

Centisome position: 5.45

GC content: 43.36

Gene sequence:

>1317_bases
ATGAAAAGTATAAAAATAAGTCTGGCATGGCAAATACTCATTGCACTGGTGTTAGGCATTTTGGTTGGTGCAGTTTTACA
TAATCAAATTGAATCCAGGGAATGGTTAGTTAGTAATATTCTGAGTCCAGCGGGCGATATATTTATCCGCTTAATTAAAA
TGATTGTTGTACCGATTGTTATTTCAACGTTAATTGTCGGTATTGCGGGGGTCGGTGATGCGAAGAAACTTGGCCGGATT
GGCCTAAAAACCATTATCTACTTTGAAGTTATCACCACGATTGCCATTATTATCGGTATCACTCTGGCGAATGTATTCCA
GCCGGGGGTGGGTATAGATATGTCTGCGCTAACCGTCGTTGATATCTCTCAGTATGAAAAAACCACTGAACAGGTGCAAA
GCGGTAGTCATAGTCTGGTTAGCACTATCTTGTCGCTGATCCCGGCCAATGTCTTTGCCTCAATGGCGAAAGGCGATATG
TTGCCGATTATTTTCTTCTCAGTGTTGTTTGGTTTAGGGCTGTCTTCATTGCCAAAAGAAACCAAAGAACCACTGTTGAA
TGTGTTCAAGGCTGTTTCTGAAAGCATGTTCAAAGTCACTCACATGATTATGCGTTATGCGCCTATCGGGGTGTTTGGCT
TGATCTCGGTGACTGTGGCTAACTTTGGTTTTGCCTCACTAATCCCTCTCGCGAAGTTAGTTATTCTGGTTTATGCCGCG
ATCCTGTTCTTTGCTTTAGTTATTCTGGGAACGGTAGCGAGATTATGTAAGCTGCGGATCTGGATATTGATTCGTATTTT
GAAAGATGAACTGATTTTGGCGTATTCCACTGCCAGTTCTGAGACAGTCTTACCGCGTATTATTGAGAAAATGGAAGCTT
ATGGCGCACCAAAAGCGATTACCAGCTTTGTGGTTCCAACGGGTTATTCATTCAACTTAGATGGCTCGACATTATATCAG
AGCATTGCGGCTATCTTCATTGCACAGTTATACGGAATCGAATTGTCTATTGGGCAAGAGATTATTTTGGTTCTGACATT
GATGGTGACCTCGAAAGGGATTGCTGGTGTACCAGGCGTCTCCTTCGTCGTATTACTGGCAACGTTGGGCAGTGTGGGTA
TTCCATTGGAAGGTCTGGCCTTCATTGCCGGTGTTGACCGTATTCTGGATATGGCCCGTACCGCGTTGAATGTGGTGGGT
AATGCATTGGCAGTATTGGTGATCGCCAAATGGGAAAATCAGTTTGACGATAAAAAAGCTAAGGCTTATGAAAAAACGTT
GTTTGCGGTAGAGCAGACGCCAGCTAATCAAAGCTAA

Upstream 100 bases:

>100_bases
TATGTTCCATCAACTATAGCCCGTATTTAATGATTAAGTATTTTATTCTAGATGCTTAGTTTCTTGCATTTTATGGAATG
CTTTGAGGAATTCTTAGGGT

Downstream 100 bases:

>100_bases
TACTCTATGTTCTTAGTGCTACAGCAGCAGTATTAGCGATAGCCTGATGAGAATGTGACTCAGCGAATAGTATCTACCCA
CTCCCCGTCAGCATCATACT

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKTLFAVEQTPANQS

Sequences:

>Translated_438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKTLFAVEQTPANQS
>Mature_438_residues
MKSIKISLAWQILIALVLGILVGAVLHNQIESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLIVGIAGVGDAKKLGRI
GLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVVDISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQFDDKKAKAYEKTLFAVEQTPANQS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=441, Percent_Identity=29.0249433106576, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40254478, Length=456, Percent_Identity=27.6315789473684, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI194239697, Length=498, Percent_Identity=28.3132530120482, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI66773030, Length=480, Percent_Identity=28.9583333333333, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI21314632, Length=442, Percent_Identity=26.6968325791855, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI262359914, Length=393, Percent_Identity=27.4809160305344, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4827012, Length=262, Percent_Identity=32.0610687022901, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI5032093, Length=412, Percent_Identity=26.2135922330097, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223468564, Length=282, Percent_Identity=28.0141843971631, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI223468566, Length=282, Percent_Identity=28.3687943262411, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI301601644, Length=158, Percent_Identity=34.1772151898734, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1790514, Length=437, Percent_Identity=81.0068649885583, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=40.1442307692308, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788024, Length=408, Percent_Identity=25.7352941176471, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789473, Length=394, Percent_Identity=23.3502538071066, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71996953, Length=462, Percent_Identity=27.0562770562771, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=448, Percent_Identity=27.0089285714286, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=448, Percent_Identity=27.0089285714286, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=426, Percent_Identity=27.2300469483568, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=450, Percent_Identity=27.5555555555556, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=410, Percent_Identity=25.3658536585366, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=413, Percent_Identity=26.634382566586, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=28.2110091743119, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=28.2110091743119, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=28.2110091743119, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281360481, Length=428, Percent_Identity=24.7663551401869, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281360483, Length=428, Percent_Identity=24.7663551401869, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137666, Length=428, Percent_Identity=24.7663551401869, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47053; Mature: 47053

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIKISLAWQILIALVLGILVGAVLHNQIESREWLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLIVGIAGVGDAKKLGRIGLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWENQFDDKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAYEKTLFAVEQTPANQS
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKSIKISLAWQILIALVLGILVGAVLHNQIESREWLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLIVGIAGVGDAKKLGRIGLKTIIYFEVITTIAIIIGITLANVFQPGVGIDMSALTVV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DISQYEKTTEQVQSGSHSLVSTILSLIPANVFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLNVFKAVSESMFKVTHMIMRYAPIGVFGLISVTVANFGFASLIPLAKLVILVYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ILFFALVILGTVARLCKLRIWILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSIGQEIILVLTLMVTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWENQFDDKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KAYEKTLFAVEQTPANQS
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]