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The map label for this gene is pyn2 [H]

Identifier: 218905225

GI number: 218905225

Start: 3926552

End: 3927856

Strand: Reverse

Name: pyn2 [H]

Synonym: BCAH820_4109

Alternate gene names: 218905225

Gene position: 3927856-3926552 (Counterclockwise)

Preceding gene: 218905226

Following gene: 218905224

Centisome position: 74.07

GC content: 38.7

Gene sequence:

>1305_bases
ATGAGAATGGTGGACCTAATTGCAAAAAAACGTGACGGACATGCATTAACGACAGAAGAAATTAACTTTATTGTTGAAGG
ATATACAAATGGTGATATTCCTGATTATCAAGTAAGTTCACTTGCAATGGCAATTTTCTTCCAAGATATGAACGATCAAG
AACGTGCAGATTTAACGATGGCAATGGTAAATAGTGGTGATACAATCGACTTATCAGCTATTGAAGGTGTAAAAGTAGAT
AAGCACTCAACAGGTGGCGTTGGTGATACAACGACACTTGTATTAGGTCCATTAGTAGCCGCTTTAGGTGTACCGGTTGC
AAAAATGTCTGGACGTGGTCTAGGACATACTGGGGGTACAATTGATAAATTAGAAGCAGTTCCAGGGTTCCATGTTGAAA
TCGAAAATGATGAATTCATGCGTCTTGTAAATGAAAATAAAATCGCAGTTATTGGTCAGAGTGGAAACTTAACACCTGCG
GATAAAAAGTTATATGCACTCCGTGATGTAACGGCAACAGTAAACTCAATTCCGCTTATTGCAAGCTCGATTATGAGTAA
AAAAATTGCTGCTGGTGCAGATGCAATTGTTCTTGATGTAAAAACTGGAGCAGGTGCATTTATGAAAACGGATGAAGATG
CAAAACGTTTAGCAGAAGCAATGGTACGCATTGGTAATAACGTTGGTCGTAATACGATGGCTGTTATTTCTGATATGAGT
CAACCACTTGGTGAGGCTATTGGTAACGCACTTGAAGTACAAGAAGCAATTGATACATTACAAGGTAAAGGACCGAAAGA
TTTAGAAGAGTTATGTTTAACACTTGGAAGTCAAATGGTATACCTTGCTGGACAAGCTTCATCTTTAGAAGATGCGCGTG
AGAAATTAATTGAAGTAATGAACAACGGTAAAGCGCTAGAATCATTTAAAACATTCTTATCAGCGCAAGGCGGCGATGCA
TCTGTTGTTGATGATCCTTCTAAATTACCACAAGCACAATTTAAAATTGAAGTGGAAGCGAAGGAAGACGGTTATGTATC
AGAAATCGTTGCAGATGAAATTGGAACAGCAGCAATGCTTTTAGGAGCAGGACGTGCGACGAAGGAATCTGAAATTGATT
TAGCAGTTGGCTTAATGCTTCGCAAAAAAGTAGGGGACAGCGTGAAAAAAGGTGAATCCCTTGTTACCATTTACGCAAAC
CGTGAAAATGTAGAAGATGTAAAAGCAAAAATTTATGAGAACATGAAGATCTCTAAAGAGCATGTAGATGCACCGACATT
AGTGCATGGCATCGTTACTGAATAA

Upstream 100 bases:

>100_bases
CTTCACCACGATGAAGTAATCGAAACGACAGAACGTGTTAAAGCTAATTTCTTAGCATTAGTAAAAGCAATCGTAAAACA
AATGAAGGGGTGACCTCACA

Downstream 100 bases:

>100_bases
TAAAGAAGGGCCAGGGAGTATTTCTCCTTGGCTTTTTTTGCTATTTTTTGTTTATAATAATAATGGGTGAAATTATGATT
AGAATTTGTGCAATAACAAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTMAMVNSGDTIDLSAIEGVKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVMNNGKALESFKTFLSAQGGDA
SVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKKGESLVTIYAN
RENVEDVKAKIYENMKISKEHVDAPTLVHGIVTE

Sequences:

>Translated_434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTMAMVNSGDTIDLSAIEGVKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVMNNGKALESFKTFLSAQGGDA
SVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKKGESLVTIYAN
RENVEDVKAKIYENMKISKEHVDAPTLVHGIVTE
>Mature_434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTMAMVNSGDTIDLSAIEGVKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVMNNGKALESFKTFLSAQGGDA
SVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKKGESLVTIYAN
RENVEDVKAKIYENMKISKEHVDAPTLVHGIVTE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=39.0663390663391, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=39.0663390663391, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=39.0663390663391, Blast_Score=277, Evalue=2e-74,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=45.5445544554455, Blast_Score=340, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46213; Mature: 46213

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTM
CCHHHHHHHCCCCCEEEHHCEEEEEEECCCCCCCCHHHHHHHHHHHEECCCCCHHHCEEE
AMVNSGDTIDLSAIEGVKVDKHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCEEEEECCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMS
HHHHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
NNGKALESFKTFLSAQGGDASVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHH
LGAGRATKESEIDLAVGLMLRKKVGDSVKKGESLVTIYANRENVEDVKAKIYENMKISKE
HCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCHH
HVDAPTLVHGIVTE
HCCCCHHHHHCCCC
>Mature Secondary Structure
MRMVDLIAKKRDGHALTTEEINFIVEGYTNGDIPDYQVSSLAMAIFFQDMNDQERADLTM
CCHHHHHHHCCCCCEEEHHCEEEEEEECCCCCCCCHHHHHHHHHHHEECCCCCHHHCEEE
AMVNSGDTIDLSAIEGVKVDKHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVPGFHVEIENDEFMRLVNENKIAVIGQSGNLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCEEEEECCHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRNTMAVISDMS
HHHHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGQASSLEDAREKLIEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
NNGKALESFKTFLSAQGGDASVVDDPSKLPQAQFKIEVEAKEDGYVSEIVADEIGTAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHH
LGAGRATKESEIDLAVGLMLRKKVGDSVKKGESLVTIYANRENVEDVKAKIYENMKISKE
HCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCHH
HVDAPTLVHGIVTE
HCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]