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The map label for this gene is murB

Identifier: 218905040

GI number: 218905040

Start: 3762060

End: 3762965

Strand: Reverse

Name: murB

Synonym: BCAH820_3924

Alternate gene names: 218905040

Gene position: 3762965-3762060 (Counterclockwise)

Preceding gene: 218905041

Following gene: 218905039

Centisome position: 70.96

GC content: 38.52

Gene sequence:

>906_bases
ATGGAGCAATTAGTAAATGAGCTTATACAAGCAAATGTTGGTCGCGTGTTAGTGGATGAACCGTTAGCACGTTATACCAC
TATGAAAATAGGTGGGCCAGCTGATATTTTAATTGTGCCAAAGCGTGTTGCTGGTATTGAAAAAACGTTACAGTTAGTAA
AGAAATATAAAACAAAGTGGACTGTAATTGGTCGTGGTTCGAACCTTCTTGTATCTGATCTAGGTATAGAAGGTGTCGTT
ATTCGTTTAGGAGAAGGATTAGACCACTTAGAAGTCGAAAAACATAGAGTAAGAGTTGGTGGTGGGTATCCCCTAATTAA
ATTATCAACTTTACTTAGTCGTCAAGGGTTAGCCGGTCTGGAGTTCGCAAGTGGTATTCCAGGAAGTGTTGGCGGTGCAG
TGTATATGAATGCAGGAGCACATAAATCGGATATATCAAACATATTATCAAAAGCTCTTATTTTGTTTGAAGACGGAACA
ATTGACTGGTTAACGCATGGAGAAATGGAGTTTTCCTATCGTACATCTGTATTGCAAACGAAACGTCCTGGTATTGTTTT
GGAGGCTGAGTTTCAATTACAGATAGGTGAGCGTGAGAGAATTGTAAGTGTTATGCAAAAGAATAAAGATTACCGTCGTG
AAACACAGCCATGGAATCATCCGTGTGCAGGAAGTGTGTTTCGGAATCCAACTCCATACTTTGCAGGAGATTTAATAGAA
AAGGCAGGGCTTCGTGGTTATCAAATAGGTGGAGCTCAAATTTCTGAAATGCATGGAAATTTTATTATTAATACTGGGGG
AGCCAGCGCGCAAGATGTCTTATCTTTAATTGCATTAATAAAACAAACAATTAAGGATAAATTTGGCGTAGAAATGCATA
CAGAAGTAGAAATCATTGGAAGATAA

Upstream 100 bases:

>100_bases
AAGCTGTATGAAGTCATGAATAAGCTTGTAAAAAAATAACGTTAGGTGAACGCCCTGCATACTACTGTAATAAGGATGCT
GAGTATGGGGGAGATTGTTT

Downstream 100 bases:

>100_bases
CGGTTATTCGTTCCGCTCATTATCATTTATGTTATAATAAGAAGATAAGAACGGCATGAGGAACATGCCGTTCTTTATGT
TACGTAGGGGGATCGTACAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase 1

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMEFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR

Sequences:

>Translated_301_residues
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMEFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR
>Mature_301_residues
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMEFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=286, Percent_Identity=26.5734265734266, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB1_BACAN (Q81WD1)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846288.1
- RefSeq:   YP_020690.1
- RefSeq:   YP_030011.1
- ProteinModelPortal:   Q81WD1
- SMR:   Q81WD1
- EnsemblBacteria:   EBBACT00000008666
- EnsemblBacteria:   EBBACT00000014590
- EnsemblBacteria:   EBBACT00000021148
- GeneID:   1087051
- GeneID:   2819707
- GeneID:   2851712
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_4048
- KEGG:   bar:GBAA_4048
- KEGG:   bat:BAS3760
- TIGR:   BA_4048
- TIGR:   GBAA_4048
- GeneTree:   EBGT00050000001391
- HOGENOM:   HBG686573
- OMA:   ILIVPKH
- ProtClustDB:   PRK13905
- BioCyc:   BANT260799:BAS3760-MONOMER
- BioCyc:   BANT261594:GBAA4048-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33017; Mature: 33017

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 174-174 ACT_SITE 225-225 ACT_SITE 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKW
CHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCEE
TVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGL
EEEECCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
EFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHGEMEFSYRTSVLQT
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEECCCEEEHHHHHHHHC
KRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
CCCCEEEEEEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIG
HCCCCEEEECCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
R
C
>Mature Secondary Structure
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKW
CHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCEE
TVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGL
EEEECCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
EFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHGEMEFSYRTSVLQT
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEECCCEEEHHHHHHHHC
KRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
CCCCEEEEEEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIG
HCCCCEEEECCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629