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The map label for this gene is coaBC [H]

Identifier: 218904999

GI number: 218904999

Start: 3721309

End: 3722514

Strand: Reverse

Name: coaBC [H]

Synonym: BCAH820_3883

Alternate gene names: 218904999

Gene position: 3722514-3721309 (Counterclockwise)

Preceding gene: 218905000

Following gene: 218904998

Centisome position: 70.2

GC content: 37.89

Gene sequence:

>1206_bases
ATGCTAAAAGGGAAAAAGATACTTTTATGTGTAACAGGAGGCATTGCGGTCTTTAAAGCGGCTGCGTTAACGAGTAAATT
GACACAAGCTGGTGCTATTGTAAAAGTAATGATGAGTGAGTCAGCAGTGAAGTTTGTTACACCTCTTACATTCCAGGCAC
TTTCTCGTCATGATGTATATACGGATACATTTGATGAGAAAGATTCAGCTGTTATTGCTCATATCGATTTAGCAGATTGG
GCAGATGTTGTACTTGTTGCACCTGCTACAGCCAATTGTATTGGAAAGCTAGCTAACGGCATTGCAGATGATATGATTAC
AACTACTTTGTTAGCTACTACAGCCCCAGTGTGGATTGCACCTGCTATGAATGTGCATATGTATGAAAATAAAATTGTTC
AAAAAAATATGATGACGTTAAAAACGTTAGGATATACATTTATTGAGCCTGGAGAAGGTTTTTTAGCGTGTGGTTATGTA
GCGAAGGGAAGATTAGAAGAACCTGAAGCGATTATTGCACGGTTAGAAGAGGCTTTTTCAGAACAAAAACCATTGCAAGG
AAAAAGGATATTAATAACTGCTGGTCCAACTCGTGAAAAGATTGACCCAGTCCGTTTTATGACTAATTTTTCTTCTGGAA
AAATGGGATATGCGATTGCGGAAGTGGCAGCGAACTTAGGCGCTGAAGTCATACTCGTTTCTGGACCGACAGCATTAAAT
CCACCATTACATGTAACTACAGTGCAAGTGGAATCTGCACAAGATATGTTAGAGGCAGTCATTCAATATTATCAAAACGT
AGATGTTGTCATTAAAACAGCAGCAGTTGCAGATTATCGTCCGAAATATGTACATGATAATAAAATGAAAAAGAAAAATG
GCGATGCTGTAATTGAACTCGAGAGAACAGTAGATATTTTAAAAACGTTAGGTGAGATGAAGGACAAACAGTTACTTATC
GGTTTTGCGGCTGAAACGACAAACGTAGAGGAATATGCAACGAAAAAATTACGTGAGAAAAATGCGAATATGATTGTTGC
AAACGACGTAAAGGCGCAAGGAGCTGGATTTGGTACAGACACGAACATTGTAACAATGTATAGAAAAGATGGAGAAGTTA
TAGAGTTGCCACTTTTAACGAAGAAAGAGGTTGCTCGTGAAATATTAAAGCAAATTGAAATGATGTTAGAAGATGATCGT
CTATGA

Upstream 100 bases:

>100_bases
AGGTTGTTATTTTTTTACGATAGGGAAGAAATATTGATACTGATGAGCTGATAATTTTGTTTCAGTATTATAAGTTTGAA
AAAGAAAGAGGACGAGCCAT

Downstream 100 bases:

>100_bases
AATTTGCAAGTGTAATTGTTGATGTACCTGCACGTCAGACAGATCGACCATTTGATTATATTATCCCTAAAAAATGGGAA
GATATTGTCCAGACAGGCAT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAANLGAEVILVSGPTALN
PPLHVTTVQVESAQDMLEAVIQYYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI
GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR
L

Sequences:

>Translated_401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAANLGAEVILVSGPTALN
PPLHVTTVQVESAQDMLEAVIQYYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI
GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR
L
>Mature_401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAANLGAEVILVSGPTALN
PPLHVTTVQVESAQDMLEAVIQYYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI
GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR
L

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=43.2911392405063, Blast_Score=291, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=36.2573099415205, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=30.7262569832402, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=29.1005291005291, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43889; Mature: 43889

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEEHHCCCHHHHHCCHHHHHHHCCCCC
TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIA
CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS
CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH
EQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAANLGAEVILVSGPTALN
HCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCC
PPLHVTTVQVESAQDMLEAVIQYYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIEL
CCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEE
ERTVDILKTLGEMKDKQLLIGFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTD
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
TNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDRL
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEEHHCCCHHHHHCCHHHHHHHCCCCC
TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIA
CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS
CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH
EQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAANLGAEVILVSGPTALN
HCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCC
PPLHVTTVQVESAQDMLEAVIQYYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIEL
CCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEE
ERTVDILKTLGEMKDKQLLIGFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTD
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
TNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDRL
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]