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The map label for this gene is hslU

Identifier: 218904957

GI number: 218904957

Start: 3678871

End: 3680262

Strand: Reverse

Name: hslU

Synonym: BCAH820_3841

Alternate gene names: 218904957

Gene position: 3680262-3678871 (Counterclockwise)

Preceding gene: 218904958

Following gene: 218904956

Centisome position: 69.4

GC content: 37.07

Gene sequence:

>1392_bases
ATGCATTTACATTTTACTCCGCGTCAAATTGTGGAAAAATTAGATCAATACATTATCGGTCAAAAAGATGCGAAGAAAGC
GGTTGCTGTAGCTTTAAGAAATCGATACCGCCGAAGTAAATTAGCTGAAAATCTACGTGATGAAATTGCACCTAAAAATA
TTTTAATGATTGGACCGACAGGTGTTGGTAAAACAGAGGTAGCACGACGAATGGCGAAACTCGTTGGAGCACCTTTTATT
AAGGTTGAAGCTACGAAATTTACAGAAGTTGGATATGTAGGTAGAGATGTAGAATCGATGGTACGTGACCTTGTGGAAAC
GTCTGTTCGTATCGTGAAAGAAGAAATGGTAGTTAAAGTACAAGACAAAGCAGAAGAACAAGCGAACCAACGTCTGGTTG
AAATTTTAGTGCCGAGTCCGGAGAAGCAATCTGGATTTAAAAACCCATTAGAAATGCTATTTGGTGGCACTCAAAATTCG
AATCAAACAACAGATTCACAGGAAGATGTTGAAATCGAAAAGAAACGTCAAGATGTGGAAAGAAAGCTTGCTGCGGGGCT
TCTTGAAGATGAAATTGTATCGATTGAAGTGACGGAACAACAGTCTTCTATGTTCGATATGTTGCAAGGAACTGGCATGG
AACAAATGGGGATGAATTTCCAAGATGCGTTAGGAAGTTTTATGCCGAAAAAAACAAAAAAACGTAAACTTTCTGTAAAA
GAAGCAAGAAAAGTCTTGACAAATGAGGAAGCACAGCGCTTAATTGATATGGATGAAGTTACACAAGAGGCTGTTTATCG
TGCTGAACAGCTCGGGATTATTTTTATCGATGAAATTGACAAAATTGCTGGTAAGCAGTCGAATAGCGTAGACGTATCAC
GTGAAGGTGTGCAACGTGACATTTTACCAATTGTAGAAGGGTCAAATGTTGCGACAAAATACGGATCAGTAAAAACGGAT
TATATTTTATTCGTTGCAGCTGGAGCGTTTCATATGTCTAAACCGTCAGATTTAATTCCGGAATTACAAGGGAGATTTCC
GATTCGAGTAGAATTAACAAAATTATCAACTGATGATTTTGTTAAAATATTAATCGAGCCTGACAATGCGTTGATTAAAC
AATATATGGCTTTATTAGCGACTGAAGGTATAGAAATTGAATTTTCAGACGAAGCTATTCGTAAGATTGCTGAGATTGCT
TATCAAGTTAATCAGGATACAGATAATATTGGAGCAAGAAGACTTCATACGATTATGGAGAAGCTCCTTGAAGATTTATC
GTTTGAAGCATCTGAAATTACGTTAGAGAAAATAACGATAACACCTCAATACGTTGAGGAGAAATTAGCAACGATTGCTA
AAAATAAAGATGTGAGCCAGTTTATTTTGTAA

Upstream 100 bases:

>100_bases
ATTGCGAAAGCGAGTTTAGAAATTGCTGGCGATATTTGTGTTTATACAAACCACAACATAATTGTGGAAGAATTGTAGAA
TCGTAAGGGAGGCATTTTAT

Downstream 100 bases:

>100_bases
TAGTGTCATCAGGTGACTCGCCCTAGTTTCCAAGTGATGAAAAAATATGTGAGTAACATGTAGGAGGAACTTTTGAAATG
GAATTATTAGCAAAAACAAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Sequences:

>Translated_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
>Mature_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.9369369369369, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=50.8695652173913, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786642, Length=227, Percent_Identity=33.4801762114537, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=31.9148936170213, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648291, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24648289, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_BACAA (C3P5N1)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868067.1
- ProteinModelPortal:   C3P5N1
- SMR:   C3P5N1
- EnsemblBacteria:   EBBACT00000130009
- GeneID:   7848332
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_3990
- GeneTree:   EBGT00050000000359
- ProtClustDB:   PRK05201
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 52214; Mature: 52214

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: BINDING 19-19 BINDING 277-277 BINDING 341-341 BINDING 413-413

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNSNQTTDSQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGTQNSNQTTDSQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYMALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA