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The map label for this gene is czcD [H]

Identifier: 218902923

GI number: 218902923

Start: 1703768

End: 1704655

Strand: Direct

Name: czcD [H]

Synonym: BCAH820_1806

Alternate gene names: 218902923

Gene position: 1703768-1704655 (Clockwise)

Preceding gene: 218902921

Following gene: 218902924

Centisome position: 32.13

GC content: 35.92

Gene sequence:

>888_bases
ATGGGACATTCGCATTCTAAAAATAAAAAAGCGTTGCTACTTGCATTCTTACTAACAACAAGTTTTATGATTGCTGAAGT
TATTGGGGGATTTGTAACAAATAGTTTAGCACTACTATCTGACGCGGGGCATATGTTAAGTGATGCGGTATCTTTAGCTT
TAAGTTTACTTGCGTTTAAGCTAGGAGAAAAAACAGCAACAGCTACGAAAACATACGGGTATAAGCGAGTCGAAATGTTA
GCGGCATTATGTAACGGTGTCGTTCTTATTGTCATTTCAGTATACATTTTTATTGAAGCAATTCGCCGTTTTAAAGAGCC
AGTTGAGATTGCTAGTAATGGGATGCTCATTATTGCTGTACTTGGTCTGCTTATTAATATTTTATCAGCTTGGATATTAA
TGAGAGGCGGAGATGTAAAGGGGAATTTGAATTTAAGGAGTGCTTTCCTACACGTATTAGGCGATTTATTAGGATCCGTC
GGAGCGATTATTGCTGCGTTACTTATTAAATTTTTCGGATGGACTGCTGCAGATGCGATTGCTAGTATTCTTGTGTCTAT
TTTAGTCATTATTAGTGGATGGCGTGTAACACGTGATACAGTCCATATATTAATGGAAGGTGCACCACAGCACATAAATG
TTGAAGAGGTAAAAAGTACATTATTAAATATTACGGTTGTAAAAGAAGTTCATGATTTGCACATATGGTCTGTCACATCG
GATTTTCAAGTATTAACTTGCCACTTGATTATTAAAGGAAATGAAACACAAAGTGTATTAAAAGAGGCTACGGAAGTATT
AAAAGAGAAGTTTCATGTAGAACATGTCACCATTCAAGTAGAAATAGATGGTGAATTTCATCATAGTGAGACAACTTGCA
AAGTATGA

Upstream 100 bases:

>100_bases
TTTGAAAAGTATCGAAGTGTGTATACAGAGGAAGCGGGATAAAGATAGGGAATTTGTTTCATACTAATGTACAGATATTG
CACTTAAAGGAGCATTTTGT

Downstream 100 bases:

>100_bases
AAGAAAAAGGATACGAAAAAGTGTTATAACATTTTTCGCGCGGCATACATATATATAATGTGGCCACAAATACTTTGTAA
GGTAAATATTTCATGAAATT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MGHSHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATATKTYGYKRVEML
AALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSV
GAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWSVTS
DFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV

Sequences:

>Translated_295_residues
MGHSHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATATKTYGYKRVEML
AALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSV
GAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWSVTS
DFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
>Mature_294_residues
GHSHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATATKTYGYKRVEMLA
ALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVG
AIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWSVTSD
FQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=34.2281879194631, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI52352805, Length=300, Percent_Identity=33, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI21359890, Length=305, Percent_Identity=34.4262295081967, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=27.6923076923077, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI289803013, Length=269, Percent_Identity=34.2007434944238, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803009, Length=269, Percent_Identity=34.2007434944238, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803007, Length=269, Percent_Identity=34.2007434944238, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289803003, Length=269, Percent_Identity=34.2007434944238, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI64762489, Length=269, Percent_Identity=34.2007434944238, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=32.1739130434783, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI52351208, Length=136, Percent_Identity=38.9705882352941, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=41.1290322580645, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI222080086, Length=128, Percent_Identity=28.90625, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI40255009, Length=128, Percent_Identity=28.90625, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=46.7625899280576, Blast_Score=207, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=35.8490566037736, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17555796, Length=307, Percent_Identity=36.1563517915309, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=34.1772151898734, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32564488, Length=312, Percent_Identity=28.525641025641, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=39.4444444444444, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323899, Length=122, Percent_Identity=38.5245901639344, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=112, Percent_Identity=41.0714285714286, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583858, Length=328, Percent_Identity=31.0975609756098, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24656728, Length=339, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656724, Length=339, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656720, Length=339, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656715, Length=339, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357035, Length=339, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585900, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24585898, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24585896, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19921672, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=33.0985915492958, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=33.0985915492958, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645863, Length=126, Percent_Identity=36.5079365079365, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32143; Mature: 32012

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHSHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEKTATATKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAV
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTAADAI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWSVTS
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECC
DFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
CCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC
>Mature Secondary Structure 
GHSHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEKTATATKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAV
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTAADAI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNITVVKEVHDLHIWSVTS
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECC
DFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
CCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]