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The map label for this gene is ndk

Identifier: 218902726

GI number: 218902726

Start: 1518783

End: 1519229

Strand: Direct

Name: ndk

Synonym: BCAH820_1609

Alternate gene names: 218902726

Gene position: 1518783-1519229 (Clockwise)

Preceding gene: 218902725

Following gene: 218902727

Centisome position: 28.64

GC content: 38.93

Gene sequence:

>447_bases
ATGGAAAAAACATTTCTAATGGTTAAACCAGACGGTGTACAACGTGCCTTCATTGGGGAAATTGTAGCTCGTTTTGAGAA
GAAGGGCTTTCAATTAGTTGGTGCAAAATTAATGCAAGTCACTCCAGAAATCGCTGGACAACACTATGCTGAGCACACAG
AAAAACCTTTCTTTGGTGAATTAGTAGACTTTATTACATCTGGTCCTGTATTCGCAATGGTATGGCAAGGTGAAGGTGTA
GTAGATACAGCTCGTAACATGATGGGTAAAACAAGACCACATGAAGCAGCTCCTGGAACAATTCGTGGAGATTTCGGTGT
AACTGTTGCGAAAAACATTATCCATGGTTCTGATTCGTTAGAAAGTGCAGAGCGCGAGATTGGTATTTTCTTTAAGGAAG
AAGAATTAGTTGACTACTCAAAATTAATGAATGAATGGATTTACTAA

Upstream 100 bases:

>100_bases
TCTCTCTATTTCAAAACTATTGCACAATTGTGATAAGGGTGTTAATATGTGTGTGGGGATATACAATTACATACATAATT
CAGAAGTGGAGAGATTTTTT

Downstream 100 bases:

>100_bases
TTATTTTGAAATAATTTGTAAACGCTTTAATCACTGTGATAATAGTAGAAAGTGCAAGGAGAATAGGGGTATTCTTCTTG
CACTTTTTTTATTTCTATTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHTEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKEEELVDYSKLMNEWIY

Sequences:

>Translated_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHTEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKEEELVDYSKLMNEWIY
>Mature_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHTEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKEEELVDYSKLMNEWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=56.0810810810811, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=56.0810810810811, Blast_Score=187, Evalue=2e-48,
Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=57.1428571428571, Blast_Score=186, Evalue=6e-48,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=54.0540540540541, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=54.0540540540541, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=54.0540540540541, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=54.0540540540541, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=54.0540540540541, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=49.6402877697842, Blast_Score=160, Evalue=4e-40,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=46.0992907801418, Blast_Score=135, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=50, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=53.7414965986395, Blast_Score=181, Evalue=3e-47,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=53.0612244897959, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=33.0882352941176, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_BACAN (Q81SV8)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843987.1
- RefSeq:   YP_018159.1
- RefSeq:   YP_027694.1
- PDB:   2VU5
- PDBsum:   2VU5
- ProteinModelPortal:   Q81SV8
- SMR:   Q81SV8
- EnsemblBacteria:   EBBACT00000008290
- EnsemblBacteria:   EBBACT00000015924
- EnsemblBacteria:   EBBACT00000023252
- GeneID:   1083673
- GeneID:   2817489
- GeneID:   2852130
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1536
- KEGG:   bar:GBAA_1536
- KEGG:   bat:BAS1425
- TIGR:   BA_1536
- TIGR:   GBAA_1536
- GeneTree:   EBGT00050000001953
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   BANT260799:BAS1425-MONOMER
- BioCyc:   BANT261594:GBAA1536-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16601; Mature: 16601

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHTEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHH
LVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCCCHH
ESAEREIGIFFKEEELVDYSKLMNEWIY
HHHHHHHCEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHTEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHH
LVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCCCHH
ESAEREIGIFFKEEELVDYSKLMNEWIY
HHHHHHHCEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629