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The map label for this gene is recQ1 [H]

Identifier: 218902696

GI number: 218902696

Start: 1493062

End: 1494591

Strand: Direct

Name: recQ1 [H]

Synonym: BCAH820_1579

Alternate gene names: 218902696

Gene position: 1493062-1494591 (Clockwise)

Preceding gene: 218902695

Following gene: 218902697

Centisome position: 28.16

GC content: 35.29

Gene sequence:

>1530_bases
ATGAAACTTGAGGAATATTTATATAGGTGGTTTGGATATTCTGAATTTCGTCCAGGTCAAAAAGGAGTCATTACAGATTT
ATTGGAAGGAAAAGATGTTATAGCGATGCTTCCGACCGGAAGGGGGAAGTCTATGTGCTATCAACTTCCAGGGCTTATGC
AAGAAGGGACAGTACTTGTTGTATCACCATTATTATCTTTGATGGAAGATCAGGTTACACAATTAAAATATGTTGTGAAA
AACCGAGTGATAGCATTTAATAGTTTTCGGACATTACAGGAAAAAAGAGAAGCGATGAAAAGATTAGCTTCTTATAAATT
TATTTTTGTTTCACCAGAGATGTTGCAGTCGGAATTGTTAATAAGAGAATTGAAGAAAGTTCATATTTCATTATTTGTTG
TGGATGAAGCTCATTGTATTTCGCAATGGGGTTATGATTTTAGACCAGATTATAAAAAACTAAATATAGTTATTAAGAAT
ATCGGGTCTCCTACGGTGCTAGCATTAACTGCAACAGCGACGAAAGATGTACTCCGAGATATAGCAGAGAGTTTGAATTT
GGAGAATGTGACGCAGCATGTATACTCTATTGATCGTCCAAATATAGCAATGGAAGTACAATTTGTAGAGACGATAGAAG
AGAAGAAAGAGGCGCTTTTGGACCAGGTGATGTATTTACAAGGGCCGGGGATTGTATATTGTTCAAGCAGAGCGTGGACA
GAACGTTTAACGGAATATTTAAGAGGAAAAGGCGTGACTGGTGTCGCTTTCTATCATGGTGGTATGGAACATGAAGAGCG
TATGTTAATTCAACAGCAGTTTATGAATGACCAATTGCAGCTTGTAATATGTACAAGTGCTTTTGGTATGGGAGTAAATA
AATCGAACACGAGATATATTATTCATTTTCACTATCCGACTAATATAGCTTCTTATTTACAAGAAATCGGAAGAGCTGGA
AGAGATGGTGAACCAAGTATAGCTATTTTACTATGTAGTCCGTTAGATCACGATTTACCAATTTCAATAATTGAAGATGA
ATTGCCAAGCCAGTCACAAATACAATTTTTATTTTCTTTACTACAGGAAAGAATGTTTCAAACGAAAGAATTACCAATAG
AAGAGGTAGAAGAAATTTGTTATAATGCAGCAAGATTTAATGAACAATATTGGCGTTTCATCCGCTATCATCTTGAACAG
CTTGGAATCATACAACAGAGAAAATTAAAATTAGAGAGCTTGTCAGATGAAATTATGAACAGATTAATAGCTGAAGTAGA
AATAAGGCTACGTAATAAATATAGTGAGCTAGAAAACATGAAAGCATGGATACAAGTGAAAGGATGTAGACGTGAATATT
TATTGCAACAGTTCGGTTACAGAAAAGAGGGCGAGTTAAAGAATTGCTGCGACTATTGTCATATTACAAAAACAGATTAT
AAAAAAAGACAAGCGCAACAATCGGATTTCGACTATAATTGGGAAACAGAGTTACAAAAGCTTTTCGGTCTAGAAAAGAT
GGGGGAATGA

Upstream 100 bases:

>100_bases
GCATTACAAACACGTAAGCTGCGTGAGTTGAAACAAGCGGTTGGAGAGGATATCTCTTATTTTGAAGTTCGTCTTGTATT
GGCGCGGATGGAGGGTATAA

Downstream 100 bases:

>100_bases
TGAACATTCAAAGGCATAATATTGAAGATATGAGTCCGAAAGAAATAAGGCTGAATCTGTATATCACACAGTTCATTATT
ATTGGTATCGGTTGTTTACT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKLEEYLYRWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQLPGLMQEGTVLVVSPLLSLMEDQVTQLKYVVK
NRVIAFNSFRTLQEKREAMKRLASYKFIFVSPEMLQSELLIRELKKVHISLFVVDEAHCISQWGYDFRPDYKKLNIVIKN
IGSPTVLALTATATKDVLRDIAESLNLENVTQHVYSIDRPNIAMEVQFVETIEEKKEALLDQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNDQLQLVICTSAFGMGVNKSNTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSQSQIQFLFSLLQERMFQTKELPIEEVEEICYNAARFNEQYWRFIRYHLEQ
LGIIQQRKLKLESLSDEIMNRLIAEVEIRLRNKYSELENMKAWIQVKGCRREYLLQQFGYRKEGELKNCCDYCHITKTDY
KKRQAQQSDFDYNWETELQKLFGLEKMGE

Sequences:

>Translated_509_residues
MKLEEYLYRWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQLPGLMQEGTVLVVSPLLSLMEDQVTQLKYVVK
NRVIAFNSFRTLQEKREAMKRLASYKFIFVSPEMLQSELLIRELKKVHISLFVVDEAHCISQWGYDFRPDYKKLNIVIKN
IGSPTVLALTATATKDVLRDIAESLNLENVTQHVYSIDRPNIAMEVQFVETIEEKKEALLDQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNDQLQLVICTSAFGMGVNKSNTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSQSQIQFLFSLLQERMFQTKELPIEEVEEICYNAARFNEQYWRFIRYHLEQ
LGIIQQRKLKLESLSDEIMNRLIAEVEIRLRNKYSELENMKAWIQVKGCRREYLLQQFGYRKEGELKNCCDYCHITKTDY
KKRQAQQSDFDYNWETELQKLFGLEKMGE
>Mature_509_residues
MKLEEYLYRWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQLPGLMQEGTVLVVSPLLSLMEDQVTQLKYVVK
NRVIAFNSFRTLQEKREAMKRLASYKFIFVSPEMLQSELLIRELKKVHISLFVVDEAHCISQWGYDFRPDYKKLNIVIKN
IGSPTVLALTATATKDVLRDIAESLNLENVTQHVYSIDRPNIAMEVQFVETIEEKKEALLDQVMYLQGPGIVYCSSRAWT
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNDQLQLVICTSAFGMGVNKSNTRYIIHFHYPTNIASYLQEIGRAG
RDGEPSIAILLCSPLDHDLPISIIEDELPSQSQIQFLFSLLQERMFQTKELPIEEVEEICYNAARFNEQYWRFIRYHLEQ
LGIIQQRKLKLESLSDEIMNRLIAEVEIRLRNKYSELENMKAWIQVKGCRREYLLQQFGYRKEGELKNCCDYCHITKTDY
KKRQAQQSDFDYNWETELQKLFGLEKMGE

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=367, Percent_Identity=38.4196185286104, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI51242943, Length=367, Percent_Identity=38.4196185286104, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI148612816, Length=357, Percent_Identity=38.9355742296919, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI110735439, Length=340, Percent_Identity=38.8235294117647, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI169218196, Length=340, Percent_Identity=38.8235294117647, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI14591902, Length=343, Percent_Identity=35.2769679300292, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI14591904, Length=343, Percent_Identity=35.2769679300292, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557365, Length=345, Percent_Identity=35.0724637681159, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI284005309, Length=357, Percent_Identity=34.733893557423, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI7661920, Length=357, Percent_Identity=22.96918767507, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI222352149, Length=345, Percent_Identity=24.3478260869565, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21071032, Length=356, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI164664518, Length=372, Percent_Identity=24.7311827956989, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI83700235, Length=338, Percent_Identity=25.1479289940828, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI13514831, Length=349, Percent_Identity=23.7822349570201, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI188035877, Length=343, Percent_Identity=20.9912536443149, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI55749865, Length=338, Percent_Identity=20.1183431952663, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI48994977, Length=342, Percent_Identity=42.6900584795322, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1787605, Length=338, Percent_Identity=21.301775147929, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32564293, Length=341, Percent_Identity=39.2961876832845, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71987997, Length=367, Percent_Identity=34.3324250681199, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71987993, Length=367, Percent_Identity=34.3324250681199, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25145561, Length=347, Percent_Identity=35.4466858789625, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17552866, Length=347, Percent_Identity=34.5821325648415, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71987143, Length=362, Percent_Identity=24.585635359116, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71995724, Length=356, Percent_Identity=23.876404494382, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17507121, Length=356, Percent_Identity=23.5955056179775, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555296, Length=338, Percent_Identity=24.2603550295858, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537549, Length=343, Percent_Identity=20.6997084548105, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=319, Percent_Identity=23.8244514106583, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=343, Percent_Identity=37.9008746355685, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6324217, Length=323, Percent_Identity=25.077399380805, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320497, Length=378, Percent_Identity=23.2804232804233, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320224, Length=366, Percent_Identity=23.4972677595628, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321360, Length=323, Percent_Identity=25.077399380805, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322912, Length=336, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322323, Length=336, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319618, Length=422, Percent_Identity=20.3791469194313, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320041, Length=347, Percent_Identity=23.342939481268, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324778, Length=349, Percent_Identity=20.3438395415473, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646066, Length=335, Percent_Identity=37.0149253731343, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24664226, Length=347, Percent_Identity=36.0230547550432, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI62472181, Length=347, Percent_Identity=36.0230547550432, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24664230, Length=347, Percent_Identity=36.0230547550432, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21358123, Length=352, Percent_Identity=35.7954545454545, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24645031, Length=351, Percent_Identity=24.2165242165242, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666101, Length=344, Percent_Identity=25.2906976744186, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583281, Length=343, Percent_Identity=23.3236151603499, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583279, Length=343, Percent_Identity=23.3236151603499, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17977678, Length=349, Percent_Identity=23.2091690544413, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355075, Length=362, Percent_Identity=22.3756906077348, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18857967, Length=377, Percent_Identity=22.2811671087533, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24582080, Length=345, Percent_Identity=23.768115942029, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582078, Length=345, Percent_Identity=23.768115942029, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136248, Length=345, Percent_Identity=23.768115942029, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582075, Length=345, Percent_Identity=23.768115942029, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644479, Length=319, Percent_Identity=23.8244514106583, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 59456; Mature: 59456

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEEYLYRWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQLPGLMQEGTVLV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCHHCCCEEE
VSPLLSLMEDQVTQLKYVVKNRVIAFNSFRTLQEKREAMKRLASYKFIFVSPEMLQSELL
HHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHH
IRELKKVHISLFVVDEAHCISQWGYDFRPDYKKLNIVIKNIGSPTVLALTATATKDVLRD
HHHHHHHEEEEEEEECHHHHHHCCCCCCCCHHHHHEEEECCCCCEEEEEEHHHHHHHHHH
IAESLNLENVTQHVYSIDRPNIAMEVQFVETIEEKKEALLDQVMYLQGPGIVYCSSRAWT
HHHHCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNDQLQLVICTSAFGMGVNKSNTRYI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCEEE
IHFHYPTNIASYLQEIGRAGRDGEPSIAILLCSPLDHDLPISIIEDELPSQSQIQFLFSL
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
LQERMFQTKELPIEEVEEICYNAARFNEQYWRFIRYHLEQLGIIQQRKLKLESLSDEIMN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RLIAEVEIRLRNKYSELENMKAWIQVKGCRREYLLQQFGYRKEGELKNCCDYCHITKTDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHH
KKRQAQQSDFDYNWETELQKLFGLEKMGE
HHHHHHCCCCCCCHHHHHHHHHCHHHCCC
>Mature Secondary Structure
MKLEEYLYRWFGYSEFRPGQKGVITDLLEGKDVIAMLPTGRGKSMCYQLPGLMQEGTVLV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCHHCCCEEE
VSPLLSLMEDQVTQLKYVVKNRVIAFNSFRTLQEKREAMKRLASYKFIFVSPEMLQSELL
HHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHH
IRELKKVHISLFVVDEAHCISQWGYDFRPDYKKLNIVIKNIGSPTVLALTATATKDVLRD
HHHHHHHEEEEEEEECHHHHHHCCCCCCCCHHHHHEEEECCCCCEEEEEEHHHHHHHHHH
IAESLNLENVTQHVYSIDRPNIAMEVQFVETIEEKKEALLDQVMYLQGPGIVYCSSRAWT
HHHHCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
ERLTEYLRGKGVTGVAFYHGGMEHEERMLIQQQFMNDQLQLVICTSAFGMGVNKSNTRYI
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCEEE
IHFHYPTNIASYLQEIGRAGRDGEPSIAILLCSPLDHDLPISIIEDELPSQSQIQFLFSL
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHH
LQERMFQTKELPIEEVEEICYNAARFNEQYWRFIRYHLEQLGIIQQRKLKLESLSDEIMN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RLIAEVEIRLRNKYSELENMKAWIQVKGCRREYLLQQFGYRKEGELKNCCDYCHITKTDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHH
KKRQAQQSDFDYNWETELQKLFGLEKMGE
HHHHHHCCCCCCCHHHHHHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]