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The map label for this gene is nhaC [H]

Identifier: 218902643

GI number: 218902643

Start: 1442617

End: 1443933

Strand: Direct

Name: nhaC [H]

Synonym: BCAH820_1526

Alternate gene names: 218902643

Gene position: 1442617-1443933 (Clockwise)

Preceding gene: 218902642

Following gene: 218902644

Centisome position: 27.21

GC content: 37.21

Gene sequence:

>1317_bases
TTGAAAGAAACGAGAGGAAATGGTTTGGCTTTATTACCACTTGGGATATTTTTGGCGCTATTTATAGGTTCTGGAATTAT
TACAGGTGATTTCTATAAATTGCCGATACTTGTAGCAATTTCAATTGCTGTAGGAGTCGCTTTAGCGATGAATCGTAAAG
AAAGCTTTCATGTCAAAGTAGAAAGATTTGCTAAAGGTGCAGGAAACCCAGATATTATGATTATGGTTCTAATCTTTGTA
CTTGCAGGAGCATTTTCTGAAACGGCAAAAGGGATGGGCGGCGTTGATTCTACAGTTAACTTAGCGTTATCAATTTTACC
GCAAGGATTTATTATAGCTGGGATTTTTGTTATAGGGGCATTTATTTCATTAGCAATGGGAACTTCAATGGGAACAATTG
CCGCATTAGCACCGATTGCTGTAGGTATTAGTGGGCAAACTGATATCTCCATTGCGCTTGCCATGGCTACCGTTGTTGGC
GGGGCGATGTTTGGTGATAATTTATCATTTATTTCAGATACAACAATCGCAGCTGTACGTTCACAAGGAACAGAAATGAA
AGATAAGTTTAAAACGAACTTTTTAATTGTATTACCAGCGGCTATTATTACAATTGTACTATTAGTAATTCTTACTTTAG
GAAGCGACACGCAAGTTAAAGCGCATAGCTTTGACTTGATAAAGATTTTACCGTATGCAGGAGTACTTATTACAGCGCTA
CTTGGTTGGAATGTACTGATTGTATTAACTGGTGGAACTGTACTATCTGGGGTTATCGGTCTTTTAGATGGAAGTTACAC
GTTAGAGAGCTTCTTTAAAAGTGTAACGACTGGAATGGGCGGCATGATGGAGTTAGTATTACTCGCTATTTTAATTGGCG
GTATGGTTGAATTGATCCAATATAATGGTGGTATTCAATATTTAATGAATCTTTTAACGCGTAACATTCGTTCTAAAAAA
GGAGCAGAGTTCGGTATCGCTGGTTTAGTAGGGATGACGAATATGTGTACAGCAAATAATACGATTTCTATTATCTTTAC
AGGTCCACTTGCAAAAAACATTGCAGATCAATATGAAATTGATCCTCGTAAATCAGCGAGTGTATTAGATCTTTTCTCAT
GCTGTGTGCAAGGATTAATTCCGTATGGTGCACAAATGTTAACAGCAGCAGGATTTGCGGCGTTATCTCCAATTGAATTG
TTACCATATGCGTTTTATCCGATCTTAGTTGGAGTATGTGGAATCATTTCTATATTAATTGGTTTCCCGAGGTTTTCTAA
AGTAACGGAAAAGAAAGAGTATCATAAAACAGCATAA

Upstream 100 bases:

>100_bases
GAGAAGAGCGTTTCTTATAGATGTATAAGACCTCTTCTCGTTGGAAGAGGTCTTTTGTTATTCATTAGAAAAAAGGTTGA
AACTAGGGAGAGATGGTACT

Downstream 100 bases:

>100_bases
TGAAAATGAAGTTTATTAAAAGTAACGAAAGCCGTTCAGAGAATGTTCTCTGTGCGGCTTTTTTTGTGCGATAAAAGAGT
GAATAATCTCATGCTACCTT

Product: Na+/H+ antiporter family protein

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVKAHSFDLIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNLLTRNIRSKK
GAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIEL
LPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA

Sequences:

>Translated_438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVKAHSFDLIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNLLTRNIRSKK
GAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIEL
LPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA
>Mature_438_residues
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFV
LAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVKAHSFDLIKILPYAGVLITAL
LGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQYNGGIQYLMNLLTRNIRSKK
GAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIEL
LPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 45970; Mature: 45970

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKV
CCCCCCCCEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHEEHH
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGA
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
FISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVR
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVKAHSFDLIKILPYAGVLITAL
HCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
LGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
HCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEI
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCC
DPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GFPRFSKVTEKKEYHKTA
CCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKV
CCCCCCCCEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCHHEEHH
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGA
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
FISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVR
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVKAHSFDLIKILPYAGVLITAL
HCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
LGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
HCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEI
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCC
DPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GFPRFSKVTEKKEYHKTA
CCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]