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The map label for this gene is 218884627

Identifier: 218884627

GI number: 218884627

Start: 1229790

End: 1231067

Strand: Direct

Name: 218884627

Synonym: DKAM_1316

Alternate gene names: NA

Gene position: 1229790-1231067 (Clockwise)

Preceding gene: 218884622

Following gene: 218884643

Centisome position: 90.08

GC content: 42.49

Gene sequence:

>1278_bases
ATGTTGAAGATTAAGGTGCTGGGAGGAGGTAGAGAAGTAGGTAGGGCAGCGTATCTTATTGAGGATGGCTCCCAGAAATT
CCTACTGGATTACGGGGTAAACTTCGATGAAAGGGATCTACCTAGGCTCCCTCATCATGTGAAGCCCCTTGAAATAAGCG
GGTTAATAATATCACATGCCCACCTAGACCATGTTGGTGCAGCACCATACCTATACATAACGGGGAGACCAAAGGCGTTC
TCAACCATGCCAACTATGGAGGTAGCTAGGTTATTAGTTATAGATTTCTTGAAGCTGAACTCTGCTGTTATAGAATATGA
TATGAGGGAGTTCGAGAACCTATATGATAACACGGTCTTCCTCGAGTATGGTGAGAAATACGAGGAGGAAGGATTTAAAC
TGGTCCTGGAGAACGCGGGACACATTATTGGTAGTAGCATGACGTACCTTGAAACAGGTAGTGGGCATAGGTTAATGTAT
ACTGGTGATATTAATAACAGGGATACATGGACTTTACCAGGTGCCGAGACCCTGGAACTAAATGTTGAAACAATACTCAT
TGAGTCAACATATGGGGGTAGAAATCATCCTCCTAGATACATTGTTGAAAAGAAACTGTTGGAGATAGTTGAGGAGACTA
TTGATAGGAAAGGGACCGTCCTAATACCGGCTTTCAGTGTTGGGCGGAGTCAGGAGATAGCCACGTTAATAGCTGCGGAA
GCACCCTATGTTGACATATACTTGGATGGCATGATCAAAGATATAACCGAGATATATCTCAGATACAAGAAGTACTTGAA
GGATTCATCCCTCTTTGCTAAAGTCTTTGAAACAGTTAACTTTGTTTCAGGTGCGAAGGAAAGAAAGAAAATCATAAACA
AGCCCTGTGTAATAATAGCTTCAGCTGGAATGCTCAAGGGAGGTCCCAGCGTCTACTACCTTAAGAAAATATATCAGAAT
CCGAGGAACTCAATAGTGATGGTGAGCTATCAAGCACCCAATAGTAATGGCCATAAATTACTAGAAGAGGGAGGGATTCC
AGAGCTGGAAATCGATAGGGTTAATGCAAGGGTTGAATGGCTTGATTTCTCCAGTCATGCAGGGCAGGATGGACTACTAG
ATATAATATCAAGATACAGGACATCACTAAAGAACATTGTTATAATCCATGGAAACGAGGATGAAGCCACCTCTTTAAGA
GACGTGATCCTTGAGAAGCTGGGTAGCGATATCAATATCTATATTCCCAAAGTCGGAGACGAAATAGTGATTCAGTGA

Upstream 100 bases:

>100_bases
GTTATAAAAAGCTTGACTATAAATCAATATGGTAGAGCACTAAAAATATGTTTCCCTCAATGGGTTTCATTGAGTTGTTT
ACCATGACTTTGGTGATACA

Downstream 100 bases:

>100_bases
GCAGCGCCGGGGCGGGGACTCGAACCCCGGACCACCGGGTTTCCGCACCAGGCTTCTCGCTTAAGCGGTTAACAGCCCGG
CGCTCTACCGAGCTGAGCTA

Product: Putative exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLKIKVLGGGREVGRAAYLIEDGSQKFLLDYGVNFDERDLPRLPHHVKPLEISGLIISHAHLDHVGAAPYLYITGRPKAF
STMPTMEVARLLVIDFLKLNSAVIEYDMREFENLYDNTVFLEYGEKYEEEGFKLVLENAGHIIGSSMTYLETGSGHRLMY
TGDINNRDTWTLPGAETLELNVETILIESTYGGRNHPPRYIVEKKLLEIVEETIDRKGTVLIPAFSVGRSQEIATLIAAE
APYVDIYLDGMIKDITEIYLRYKKYLKDSSLFAKVFETVNFVSGAKERKKIINKPCVIIASAGMLKGGPSVYYLKKIYQN
PRNSIVMVSYQAPNSNGHKLLEEGGIPELEIDRVNARVEWLDFSSHAGQDGLLDIISRYRTSLKNIVIIHGNEDEATSLR
DVILEKLGSDINIYIPKVGDEIVIQ

Sequences:

>Translated_425_residues
MLKIKVLGGGREVGRAAYLIEDGSQKFLLDYGVNFDERDLPRLPHHVKPLEISGLIISHAHLDHVGAAPYLYITGRPKAF
STMPTMEVARLLVIDFLKLNSAVIEYDMREFENLYDNTVFLEYGEKYEEEGFKLVLENAGHIIGSSMTYLETGSGHRLMY
TGDINNRDTWTLPGAETLELNVETILIESTYGGRNHPPRYIVEKKLLEIVEETIDRKGTVLIPAFSVGRSQEIATLIAAE
APYVDIYLDGMIKDITEIYLRYKKYLKDSSLFAKVFETVNFVSGAKERKKIINKPCVIIASAGMLKGGPSVYYLKKIYQN
PRNSIVMVSYQAPNSNGHKLLEEGGIPELEIDRVNARVEWLDFSSHAGQDGLLDIISRYRTSLKNIVIIHGNEDEATSLR
DVILEKLGSDINIYIPKVGDEIVIQ
>Mature_425_residues
MLKIKVLGGGREVGRAAYLIEDGSQKFLLDYGVNFDERDLPRLPHHVKPLEISGLIISHAHLDHVGAAPYLYITGRPKAF
STMPTMEVARLLVIDFLKLNSAVIEYDMREFENLYDNTVFLEYGEKYEEEGFKLVLENAGHIIGSSMTYLETGSGHRLMY
TGDINNRDTWTLPGAETLELNVETILIESTYGGRNHPPRYIVEKKLLEIVEETIDRKGTVLIPAFSVGRSQEIATLIAAE
APYVDIYLDGMIKDITEIYLRYKKYLKDSSLFAKVFETVNFVSGAKERKKIINKPCVIIASAGMLKGGPSVYYLKKIYQN
PRNSIVMVSYQAPNSNGHKLLEEGGIPELEIDRVNARVEWLDFSSHAGQDGLLDIISRYRTSLKNIVIIHGNEDEATSLR
DVILEKLGSDINIYIPKVGDEIVIQ

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=444, Percent_Identity=26.5765765765766, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI33300633, Length=457, Percent_Identity=26.0393873085339, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI34101288, Length=372, Percent_Identity=21.7741935483871, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566029, Length=454, Percent_Identity=26.431718061674, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32564696, Length=460, Percent_Identity=26.304347826087, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17559452, Length=373, Percent_Identity=21.71581769437, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323307, Length=463, Percent_Identity=24.622030237581, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24648013, Length=450, Percent_Identity=26.2222222222222, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21358523, Length=457, Percent_Identity=27.7899343544858, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21358013, Length=386, Percent_Identity=20.7253886010363, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 47848; Mature: 47848

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIKVLGGGREVGRAAYLIEDGSQKFLLDYGVNFDERDLPRLPHHVKPLEISGLIISHA
CEEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEC
HLDHVGAAPYLYITGRPKAFSTMPTMEVARLLVIDFLKLNSAVIEYDMREFENLYDNTVF
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEE
LEYGEKYEEEGFKLVLENAGHIIGSSMTYLETGSGHRLMYTGDINNRDTWTLPGAETLEL
EECCCHHHHCCCEEEEECCCCEECCCEEEEECCCCCEEEEECCCCCCCEEECCCCCEEEE
NVETILIESTYGGRNHPPRYIVEKKLLEIVEETIDRKGTVLIPAFSVGRSQEIATLIAAE
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEECC
APYVDIYLDGMIKDITEIYLRYKKYLKDSSLFAKVFETVNFVSGAKERKKIINKPCVIIA
CCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEE
SAGMLKGGPSVYYLKKIYQNPRNSIVMVSYQAPNSNGHKLLEEGGIPELEIDRVNARVEW
ECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCCCCCCEEEEEECCEEEE
LDFSSHAGQDGLLDIISRYRTSLKNIVIIHGNEDEATSLRDVILEKLGSDINIYIPKVGD
EECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCC
EIVIQ
EEEEC
>Mature Secondary Structure
MLKIKVLGGGREVGRAAYLIEDGSQKFLLDYGVNFDERDLPRLPHHVKPLEISGLIISHA
CEEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEC
HLDHVGAAPYLYITGRPKAFSTMPTMEVARLLVIDFLKLNSAVIEYDMREFENLYDNTVF
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEE
LEYGEKYEEEGFKLVLENAGHIIGSSMTYLETGSGHRLMYTGDINNRDTWTLPGAETLEL
EECCCHHHHCCCEEEEECCCCEECCCEEEEECCCCCEEEEECCCCCCCEEECCCCCEEEE
NVETILIESTYGGRNHPPRYIVEKKLLEIVEETIDRKGTVLIPAFSVGRSQEIATLIAAE
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEECC
APYVDIYLDGMIKDITEIYLRYKKYLKDSSLFAKVFETVNFVSGAKERKKIINKPCVIIA
CCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEE
SAGMLKGGPSVYYLKKIYQNPRNSIVMVSYQAPNSNGHKLLEEGGIPELEIDRVNARVEW
ECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHCCCCCCEEEEEECCEEEE
LDFSSHAGQDGLLDIISRYRTSLKNIVIIHGNEDEATSLRDVILEKLGSDINIYIPKVGD
EECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCC
EIVIQ
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]