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The map label for this gene is map [H]

Identifier: 218884550

GI number: 218884550

Start: 1160712

End: 1161608

Strand: Direct

Name: map [H]

Synonym: DKAM_1239

Alternate gene names: 218884550

Gene position: 1160712-1161608 (Clockwise)

Preceding gene: 218884547

Following gene: 218884551

Centisome position: 85.02

GC content: 46.93

Gene sequence:

>897_bases
GTGGTAATGCTTACTGATGAAGCAGTGGAAATGCTGAGACGGGCGGGCTGGATAGCCAGGGCTGTGAGGGAGGAAGCCGT
TAAACTAGTTAAACCCGGTATGAGTTTCCTAGAAATAGCTGAACATGTTGAGAACAGGATAAGGGAGCTCGGTGGAGAGC
CAGCATTTCCCGTGAACATCGGTGTGAACCAGGTTGCAGCACACTATACCCCTGTACCTGGTGACACCGGTAGAATACCG
GACGGCTCAGTTGTGAAGATAGATATAGGGGTTCATGTGAAGGGATATATAGCTGACACAGCTGCCACGGTCTCATTCAA
CCCTGCTTACGAGGGCCTCGTAGAGGCTTCACGGCTTGCATTGGAGAGGGTTGTTGAAGCTGTAAGACCAGGGATCAAGG
CTAATGAGATAGGGAGGATAATCATGGAGACTATTAAATCGATGGGTTTCAACCCTGTGAGAAACCTCAGTGGTCACAGT
ATAGATCAGTATATGATTCATTCCGGGCTCAGCATACCCAACTACGATGACTTCTTCTCGGGATGGAGGCTTGGACCCGG
GGTCTATGCTGTGGAGCCATTTGCCTCTACGGGAGTCGGCCTCGTGGAAGAGGGGAAGCAGGTTACAATATATTCTCTTA
AGAAGAGGAAGAGTAGACTACCTCAAAGCGTTATGGAGGTTTATGAGAAGATAATGGATGAGAGGAAGACCCTTCCATTC
GCTGAGAGATGGTTACTCAAATATAGCGGGAATACTAGGTCAATAATATACTATATGAGTAAAGCCGGGTTGCTGCATGA
ATACCCTGTTCTACTCGAGAAATCCAATGGCATTGTTTCACAGTTCGAGCACACATTTATAATACTTCATAGGGAAGTTA
TTGTTACGACTATTTAA

Upstream 100 bases:

>100_bases
AGATACTTGATTACAGCCATCGGATTCACCCAGTGTTCATAATATAATTAAGTAAAACTATATATCTCTTGATCAAGATA
GCTCCATACATCCATGGTGA

Downstream 100 bases:

>100_bases
ATCTCTCTTCTAATAAATATCATGGCTAATGAGAAGAATACAGTAGCGGTGAATTAGATGGATGGCGATACCGCTTCACT
AATAATACAGGTTATCTGGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MVMLTDEAVEMLRRAGWIARAVREEAVKLVKPGMSFLEIAEHVENRIRELGGEPAFPVNIGVNQVAAHYTPVPGDTGRIP
DGSVVKIDIGVHVKGYIADTAATVSFNPAYEGLVEASRLALERVVEAVRPGIKANEIGRIIMETIKSMGFNPVRNLSGHS
IDQYMIHSGLSIPNYDDFFSGWRLGPGVYAVEPFASTGVGLVEEGKQVTIYSLKKRKSRLPQSVMEVYEKIMDERKTLPF
AERWLLKYSGNTRSIIYYMSKAGLLHEYPVLLEKSNGIVSQFEHTFIILHREVIVTTI

Sequences:

>Translated_298_residues
MVMLTDEAVEMLRRAGWIARAVREEAVKLVKPGMSFLEIAEHVENRIRELGGEPAFPVNIGVNQVAAHYTPVPGDTGRIP
DGSVVKIDIGVHVKGYIADTAATVSFNPAYEGLVEASRLALERVVEAVRPGIKANEIGRIIMETIKSMGFNPVRNLSGHS
IDQYMIHSGLSIPNYDDFFSGWRLGPGVYAVEPFASTGVGLVEEGKQVTIYSLKKRKSRLPQSVMEVYEKIMDERKTLPF
AERWLLKYSGNTRSIIYYMSKAGLLHEYPVLLEKSNGIVSQFEHTFIILHREVIVTTI
>Mature_298_residues
MVMLTDEAVEMLRRAGWIARAVREEAVKLVKPGMSFLEIAEHVENRIRELGGEPAFPVNIGVNQVAAHYTPVPGDTGRIP
DGSVVKIDIGVHVKGYIADTAATVSFNPAYEGLVEASRLALERVVEAVRPGIKANEIGRIIMETIKSMGFNPVRNLSGHS
IDQYMIHSGLSIPNYDDFFSGWRLGPGVYAVEPFASTGVGLVEEGKQVTIYSLKKRKSRLPQSVMEVYEKIMDERKTLPF
AERWLLKYSGNTRSIIYYMSKAGLLHEYPVLLEKSNGIVSQFEHTFIILHREVIVTTI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=302, Percent_Identity=32.7814569536424, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI124494254, Length=266, Percent_Identity=26.6917293233083, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI164420681, Length=208, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=29.4685990338164, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544396, Length=305, Percent_Identity=32.1311475409836, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17542840, Length=328, Percent_Identity=24.0853658536585, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=210, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319380, Length=313, Percent_Identity=30.6709265175719, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323273, Length=206, Percent_Identity=27.6699029126214, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137568, Length=297, Percent_Identity=32.3232323232323, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21355531, Length=213, Percent_Identity=29.5774647887324, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24658585, Length=328, Percent_Identity=22.8658536585366, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24583427, Length=202, Percent_Identity=27.7227722772277, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 33217; Mature: 33217

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMLTDEAVEMLRRAGWIARAVREEAVKLVKPGMSFLEIAEHVENRIRELGGEPAFPVNI
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEC
GVNQVAAHYTPVPGDTGRIPDGSVVKIDIGVHVKGYIADTAATVSFNPAYEGLVEASRLA
CHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEEEEEECCEEEEEECHHHHHHHHHHHHH
LERVVEAVRPGIKANEIGRIIMETIKSMGFNPVRNLSGHSIDQYMIHSGLSIPNYDDFFS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHCCCCCCCCHHHHC
GWRLGPGVYAVEPFASTGVGLVEEGKQVTIYSLKKRKSRLPQSVMEVYEKIMDERKTLPF
CCCCCCCCEEECCHHHCCCCHHHCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
AERWLLKYSGNTRSIIYYMSKAGLLHEYPVLLEKSNGIVSQFEHTFIILHREVIVTTI
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHCCEEEEEEEEEEEECC
>Mature Secondary Structure
MVMLTDEAVEMLRRAGWIARAVREEAVKLVKPGMSFLEIAEHVENRIRELGGEPAFPVNI
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEC
GVNQVAAHYTPVPGDTGRIPDGSVVKIDIGVHVKGYIADTAATVSFNPAYEGLVEASRLA
CHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEEEEEECCEEEEEECHHHHHHHHHHHHH
LERVVEAVRPGIKANEIGRIIMETIKSMGFNPVRNLSGHSIDQYMIHSGLSIPNYDDFFS
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHCCCCCCCCHHHHC
GWRLGPGVYAVEPFASTGVGLVEEGKQVTIYSLKKRKSRLPQSVMEVYEKIMDERKTLPF
CCCCCCCCEEECCHHHCCCCHHHCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
AERWLLKYSGNTRSIIYYMSKAGLLHEYPVLLEKSNGIVSQFEHTFIILHREVIVTTI
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]