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The map label for this gene is proC [H]

Identifier: 218884517

GI number: 218884517

Start: 1127607

End: 1128092

Strand: Direct

Name: proC [H]

Synonym: DKAM_1206

Alternate gene names: 218884517

Gene position: 1127607-1128092 (Clockwise)

Preceding gene: 218884516

Following gene: 218884518

Centisome position: 82.6

GC content: 56.79

Gene sequence:

>486_bases
GTGACGTCCGTAAGTGGGGGTAGTATAGCGTGTACAGAGGCTTTAGCCGTCTGCTCGCAAACCCCGTGTCTCGAGGGGTC
CTCAGCAAGTGCGGACGCGCCTGCTGTCTACTACAATATCGATAGGATAAGGAGCTGGGTGAGGAAACACGCCCTCAACA
ACCTGGCATTCATTTTCAAGCAGTGCTTGGAAATAGATAAATCATACAATTACGTGCGGTGGCCGAGGGACCTCGCCTAC
AGTGCGGCTCTCGACGTTCTAGAGGGGACGAGCAGACTACTGCGGGAGTCCGGTACACACCCGTTCAAGCTCAGAGACGA
CGTGACGACCCCCGCGGGCACCACTATAAGAGGCCTTATAGCCATGGAGTCCGAGGGGGTTAAAGCAGCCCTCATGAAGG
CGGTCGAGTCGGCGTACAGGAGGTCGCTGGAGATTGGGGCGGAGATAGACGCGAGAGTCAAGAGAGAACTCGGCATCGGC
GACTAA

Upstream 100 bases:

>100_bases
GAGCTCCGCCAGCTGGGTGAAGGAGAACTCGACTTTGTAGGCGAGGACATATATCGCTCGCTGGAGAGACTGTAGGAGGT
CAGGGTTGTCAAAGGTAGCT

Downstream 100 bases:

>100_bases
CGGTACGGTTACCGCGTACTAGCACCCGTCTAGCTTGGTCTAGAACCTACGGGCCCGTGTTTGAGCGTGTAGTTGTGGGA
AAACTAAGAATAAGGGTTCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MTSVSGGSIACTEALAVCSQTPCLEGSSASADAPAVYYNIDRIRSWVRKHALNNLAFIFKQCLEIDKSYNYVRWPRDLAY
SAALDVLEGTSRLLRESGTHPFKLRDDVTTPAGTTIRGLIAMESEGVKAALMKAVESAYRRSLEIGAEIDARVKRELGIG
D

Sequences:

>Translated_161_residues
MTSVSGGSIACTEALAVCSQTPCLEGSSASADAPAVYYNIDRIRSWVRKHALNNLAFIFKQCLEIDKSYNYVRWPRDLAY
SAALDVLEGTSRLLRESGTHPFKLRDDVTTPAGTTIRGLIAMESEGVKAALMKAVESAYRRSLEIGAEIDARVKRELGIG
D
>Mature_160_residues
TSVSGGSIACTEALAVCSQTPCLEGSSASADAPAVYYNIDRIRSWVRKHALNNLAFIFKQCLEIDKSYNYVRWPRDLAYS
AALDVLEGTSRLLRESGTHPFKLRDDVTTPAGTTIRGLIAMESEGVKAALMKAVESAYRRSLEIGAEIDARVKRELGIGD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=122, Percent_Identity=35.2459016393443, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17569021, Length=75, Percent_Identity=45.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320861, Length=91, Percent_Identity=37.3626373626374, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647700, Length=90, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358587, Length=90, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 17559; Mature: 17428

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVSGGSIACTEALAVCSQTPCLEGSSASADAPAVYYNIDRIRSWVRKHALNNLAFIFK
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
QCLEIDKSYNYVRWPRDLAYSAALDVLEGTSRLLRESGTHPFKLRDDVTTPAGTTIRGLI
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHEE
AMESEGVKAALMKAVESAYRRSLEIGAEIDARVKRELGIGD
EECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSVSGGSIACTEALAVCSQTPCLEGSSASADAPAVYYNIDRIRSWVRKHALNNLAFIFK
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
QCLEIDKSYNYVRWPRDLAYSAALDVLEGTSRLLRESGTHPFKLRDDVTTPAGTTIRGLI
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHEE
AMESEGVKAALMKAVESAYRRSLEIGAEIDARVKRELGIGD
EECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]