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The map label for this gene is eif2b [H]

Identifier: 218884394

GI number: 218884394

Start: 1024452

End: 1024877

Strand: Direct

Name: eif2b [H]

Synonym: DKAM_1083

Alternate gene names: 218884394

Gene position: 1024452-1024877 (Clockwise)

Preceding gene: 218884392

Following gene: 218884395

Centisome position: 75.04

GC content: 45.31

Gene sequence:

>426_bases
TTGAGTAGGCAGAGCCTACCAGGATATGAGAAACTAGTTGAGAGAGCCTTTGAGAAGCTTGGAGGCAAGCGTGGGAGCGG
CGAAGTATTTGAGATGCCCCATGCCGACGTACTCGTCATCGGGAGTAAAACAGTTGTGCAAAATTTCAGGCAGATAGCCA
GCGTGCTTAATAGGGATGAAGAGTTATTAAAGAGGTACTTCATGAAGGAGTTGAATGTGCCAGGCTCAATCAATGAAGCT
GGCCAACTGGAGTTGAAGGGCAAGTTTAATCCGCAGGCAATCAATCAGTTACTAGTAAGGTTTGTAGAGAGGTATGTTAA
GTGTAGCACATGTGGTTCAGTACATACAAGGTTAACTAAGAAGGGAAAGGTATTCGTGCTTAGATGCGATGCATGCGGTG
CTGAGACAACTCTTCCAGCATTTTAA

Upstream 100 bases:

>100_bases
TCCAGCCATCCCCGGCGTAAAGATACCTGATATCCTGCTTCTTCATAAGATTACATATATATAACCCTATTATATCATCC
ATGGAGCATAGGTGTGTAAA

Downstream 100 bases:

>100_bases
GGTGTAATCATGGAGAACCGAGGGAAGGAAAGGGTTAAGACCTATGTTAAGAAACAAGTTGTCGATGGAGAGGTAATCAT
TGCAGCATGCGATGAAAACA

Product: putative translation initiation factor aIF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MSRQSLPGYEKLVERAFEKLGGKRGSGEVFEMPHADVLVIGSKTVVQNFRQIASVLNRDEELLKRYFMKELNVPGSINEA
GQLELKGKFNPQAINQLLVRFVERYVKCSTCGSVHTRLTKKGKVFVLRCDACGAETTLPAF

Sequences:

>Translated_141_residues
MSRQSLPGYEKLVERAFEKLGGKRGSGEVFEMPHADVLVIGSKTVVQNFRQIASVLNRDEELLKRYFMKELNVPGSINEA
GQLELKGKFNPQAINQLLVRFVERYVKCSTCGSVHTRLTKKGKVFVLRCDACGAETTLPAF
>Mature_140_residues
SRQSLPGYEKLVERAFEKLGGKRGSGEVFEMPHADVLVIGSKTVVQNFRQIASVLNRDEELLKRYFMKELNVPGSINEAG
QLELKGKFNPQAINQLLVRFVERYVKCSTCGSVHTRLTKKGKVFVLRCDACGAETTLPAF

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=132, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508049, Length=118, Percent_Identity=30.5084745762712, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325018, Length=138, Percent_Identity=34.7826086956522, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647377, Length=132, Percent_Identity=36.3636363636364, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B [H]

EC number: NA

Molecular weight: Translated: 15794; Mature: 15662

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQSLPGYEKLVERAFEKLGGKRGSGEVFEMPHADVLVIGSKTVVQNFRQIASVLNRDE
CCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHCCCH
ELLKRYFMKELNVPGSINEAGQLELKGKFNPQAINQLLVRFVERYVKCSTCGSVHTRLTK
HHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
KGKVFVLRCDACGAETTLPAF
CCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SRQSLPGYEKLVERAFEKLGGKRGSGEVFEMPHADVLVIGSKTVVQNFRQIASVLNRDE
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHCCCH
ELLKRYFMKELNVPGSINEAGQLELKGKFNPQAINQLLVRFVERYVKCSTCGSVHTRLTK
HHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
KGKVFVLRCDACGAETTLPAF
CCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA