Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 218884328

GI number: 218884328

Start: 966500

End: 968026

Strand: Direct

Name: nuoM [H]

Synonym: DKAM_1017

Alternate gene names: 218884328

Gene position: 966500-968026 (Clockwise)

Preceding gene: 218884327

Following gene: 218884329

Centisome position: 70.79

GC content: 44.99

Gene sequence:

>1527_bases
GTGAGCTATGTGAACACGCTAGCCACTAGTATACTGCTCTATCTTTTCTCACTTGTAATACTCATATTCATAAGTAGACC
ATATTTAAATCCTTTACCCAGGTTTCTCATAAAACTGATCCCATATGGTTTAACCGGTTTAGCCATATATCTCGAGTACA
ATAGTGGTTTAATAGATGATTTCCCCACACTACTAGCCTACACAACACTGGTTCTAGGATATATTATAGGCATATATTCA
ACATATTATTTCAAGCTAGAGGAATACCATGGGAGATTCGATACCGTAATAGACTTATTCGTAATCCTTGTAGCTGCGAC
CTATGGCTCGCCAAACCTTATATCGCTGGCGGCAATGTGGTCAGCCGCAGAGATTATTGGATGGTACCTCATCGTTGAGG
GAGAGGCACACTCCATAGAGGGCTCACTGAGATCCTCGAGAGGATACCTGCTTACATCAACACTTACATTCGAGATCTCC
GTTTTCACAGTGATACTGGTCTCAATATTATCGGTAATGGCAACCATGGCCTCCGTGGACATAGGGTTCCTGATTAAGCC
GTTTAAAACTATACCGTCTCACAGTGAGGCAAGCATATACTTTATTCCACTATTAATCGTTGGATTCATAGCTAAAACAG
CAAATATCCCGCTACACTTCTGGCTACCCGGGGCGCATTCAGCAGCACCTTCACCGGCCTCAGCGATACTGAGTGGTTTA
ATGACTCCGCTGGGCTTCTACGGGTTATACAGGGTGCTTAAACTAGTCGACTTATCGAGCTATAGCATGGAGCTAGCCAT
GGTCTTAGCCATCCTAGGATTCATGTCAGTTATCTATGGATGGATACAGGTATCTGCCCAGAGGGATGGTAAGAAAATAC
TTGCATATGCAACCATAGCGACAAACGGCTATATAAGCATGGTTTTCGCACTATATGTTCTCAACCCCTCCAACGGCATG
GAAAACCTGCTCGGGCTCTCGATACTAATGCATGCAGCATATAAGGTAACGCTGTTTAGTGAAATGGGGTTGATCGAGGC
ATCTTACAGGACCAGGTATATACATGGTATAAGAGGACTCTCGAAAACACTGCCCCTGTCATCGATGGGGGGACTCCTGG
CCGTGCTCACATTAATGGGTGCCCCAGGTACAATAGGTTTCACGGTTAAAGCGCTCTCAGTATACTATATCATATCCCAG
GCATTAGACCCGGCTAGATTACTGATACTGGTGGGATTCATAACATATATGGCGATATCGGCATACCTAGCCGTGAAATA
CATGACGATATACTTTAGCACGCCGCACCCACCCTTCCCAGAGGAACCCAGTGAGATACCTAGAGTAGCCCAGATACCCG
TACTCGTCCTCGGCTTATCAAATGTCTACCTACCAATAGTATCGATACCATTACTTAAAGAATTAGCGGATTTAATCCTC
CTGTTTTCAATGGTGTCACCCCTGATGCTTCTCGCTACGGTACTCATGTACCTCACAGTGGCAAGAGAGAGGGGTGTTAA
GCATTGA

Upstream 100 bases:

>100_bases
ATAATATACGGGGAGGAAGCATTGGTATTCGATAAGGCGAAGAAGAAGGCAGCTGAAGCTATGGCGAGGGCAAGGTTCGA
GACACTGTAGGTGAAGCTAT

Downstream 100 bases:

>100_bases
GTATGATTCACGGTATAATCACCTCGGCATCATACATACTCGTGTTAACAGGATCAGCGACAAGTGATAGCCTGACCAGG
CTTAGCAGGGTGCTCAGAGT

Product: NADH/ubiquinone/plastoquinone (complex I)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSYVNTLATSILLYLFSLVILIFISRPYLNPLPRFLIKLIPYGLTGLAIYLEYNSGLIDDFPTLLAYTTLVLGYIIGIYS
TYYFKLEEYHGRFDTVIDLFVILVAATYGSPNLISLAAMWSAAEIIGWYLIVEGEAHSIEGSLRSSRGYLLTSTLTFEIS
VFTVILVSILSVMATMASVDIGFLIKPFKTIPSHSEASIYFIPLLIVGFIAKTANIPLHFWLPGAHSAAPSPASAILSGL
MTPLGFYGLYRVLKLVDLSSYSMELAMVLAILGFMSVIYGWIQVSAQRDGKKILAYATIATNGYISMVFALYVLNPSNGM
ENLLGLSILMHAAYKVTLFSEMGLIEASYRTRYIHGIRGLSKTLPLSSMGGLLAVLTLMGAPGTIGFTVKALSVYYIISQ
ALDPARLLILVGFITYMAISAYLAVKYMTIYFSTPHPPFPEEPSEIPRVAQIPVLVLGLSNVYLPIVSIPLLKELADLIL
LFSMVSPLMLLATVLMYLTVARERGVKH

Sequences:

>Translated_508_residues
MSYVNTLATSILLYLFSLVILIFISRPYLNPLPRFLIKLIPYGLTGLAIYLEYNSGLIDDFPTLLAYTTLVLGYIIGIYS
TYYFKLEEYHGRFDTVIDLFVILVAATYGSPNLISLAAMWSAAEIIGWYLIVEGEAHSIEGSLRSSRGYLLTSTLTFEIS
VFTVILVSILSVMATMASVDIGFLIKPFKTIPSHSEASIYFIPLLIVGFIAKTANIPLHFWLPGAHSAAPSPASAILSGL
MTPLGFYGLYRVLKLVDLSSYSMELAMVLAILGFMSVIYGWIQVSAQRDGKKILAYATIATNGYISMVFALYVLNPSNGM
ENLLGLSILMHAAYKVTLFSEMGLIEASYRTRYIHGIRGLSKTLPLSSMGGLLAVLTLMGAPGTIGFTVKALSVYYIISQ
ALDPARLLILVGFITYMAISAYLAVKYMTIYFSTPHPPFPEEPSEIPRVAQIPVLVLGLSNVYLPIVSIPLLKELADLIL
LFSMVSPLMLLATVLMYLTVARERGVKH
>Mature_507_residues
SYVNTLATSILLYLFSLVILIFISRPYLNPLPRFLIKLIPYGLTGLAIYLEYNSGLIDDFPTLLAYTTLVLGYIIGIYST
YYFKLEEYHGRFDTVIDLFVILVAATYGSPNLISLAAMWSAAEIIGWYLIVEGEAHSIEGSLRSSRGYLLTSTLTFEISV
FTVILVSILSVMATMASVDIGFLIKPFKTIPSHSEASIYFIPLLIVGFIAKTANIPLHFWLPGAHSAAPSPASAILSGLM
TPLGFYGLYRVLKLVDLSSYSMELAMVLAILGFMSVIYGWIQVSAQRDGKKILAYATIATNGYISMVFALYVLNPSNGME
NLLGLSILMHAAYKVTLFSEMGLIEASYRTRYIHGIRGLSKTLPLSSMGGLLAVLTLMGAPGTIGFTVKALSVYYIISQA
LDPARLLILVGFITYMAISAYLAVKYMTIYFSTPHPPFPEEPSEIPRVAQIPVLVLGLSNVYLPIVSIPLLKELADLILL
FSMVSPLMLLATVLMYLTVARERGVKH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Escherichia coli, GI1788827, Length=287, Percent_Identity=29.9651567944251, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788831, Length=328, Percent_Identity=28.6585365853659, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788829, Length=379, Percent_Identity=25.3298153034301, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693160, Length=402, Percent_Identity=25.8706467661692, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788613, Length=182, Percent_Identity=31.8681318681319, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788614, Length=310, Percent_Identity=22.9032258064516, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55821; Mature: 55690

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVNTLATSILLYLFSLVILIFISRPYLNPLPRFLIKLIPYGLTGLAIYLEYNSGLIDD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
FPTLLAYTTLVLGYIIGIYSTYYFKLEEYHGRFDTVIDLFVILVAATYGSPNLISLAAMW
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SAAEIIGWYLIVEGEAHSIEGSLRSSRGYLLTSTLTFEISVFTVILVSILSVMATMASVD
HHHHHHEEEEEEECCCCCCCCCHHCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
IGFLIKPFKTIPSHSEASIYFIPLLIVGFIAKTANIPLHFWLPGAHSAAPSPASAILSGL
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHH
MTPLGFYGLYRVLKLVDLSSYSMELAMVLAILGFMSVIYGWIQVSAQRDGKKILAYATIA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
TNGYISMVFALYVLNPSNGMENLLGLSILMHAAYKVTLFSEMGLIEASYRTRYIHGIRGL
CCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHH
SKTLPLSSMGGLLAVLTLMGAPGTIGFTVKALSVYYIISQALDPARLLILVGFITYMAIS
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AYLAVKYMTIYFSTPHPPFPEEPSEIPRVAQIPVLVLGLSNVYLPIVSIPLLKELADLIL
HHHHHHHEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
LFSMVSPLMLLATVLMYLTVARERGVKH
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SYVNTLATSILLYLFSLVILIFISRPYLNPLPRFLIKLIPYGLTGLAIYLEYNSGLIDD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHH
FPTLLAYTTLVLGYIIGIYSTYYFKLEEYHGRFDTVIDLFVILVAATYGSPNLISLAAMW
HHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SAAEIIGWYLIVEGEAHSIEGSLRSSRGYLLTSTLTFEISVFTVILVSILSVMATMASVD
HHHHHHEEEEEEECCCCCCCCCHHCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
IGFLIKPFKTIPSHSEASIYFIPLLIVGFIAKTANIPLHFWLPGAHSAAPSPASAILSGL
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHH
MTPLGFYGLYRVLKLVDLSSYSMELAMVLAILGFMSVIYGWIQVSAQRDGKKILAYATIA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
TNGYISMVFALYVLNPSNGMENLLGLSILMHAAYKVTLFSEMGLIEASYRTRYIHGIRGL
CCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHH
SKTLPLSSMGGLLAVLTLMGAPGTIGFTVKALSVYYIISQALDPARLLILVGFITYMAIS
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AYLAVKYMTIYFSTPHPPFPEEPSEIPRVAQIPVLVLGLSNVYLPIVSIPLLKELADLIL
HHHHHHHEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
LFSMVSPLMLLATVLMYLTVARERGVKH
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA