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The map label for this gene is nudF [H]

Identifier: 218884298

GI number: 218884298

Start: 935921

End: 936472

Strand: Direct

Name: nudF [H]

Synonym: DKAM_0987

Alternate gene names: 218884298

Gene position: 935921-936472 (Clockwise)

Preceding gene: 218884291

Following gene: 218884299

Centisome position: 68.55

GC content: 49.46

Gene sequence:

>552_bases
GTGGAAGTGAATACCATGGATAAGCCACTAGTATTGAGGGAAGAATTACTGGTTGAAGGGCTTCGATTCAATGTTGTCAG
GAGATACTATAGAAAAACCAGCGGCGACGAGTTCGCAAGGGATATCGTCGTGTTCCCTGAGGCAGTGGCTGTACTACCAA
TCCTAGGGAGTCATGAGGTAATCTTGCTGAGGCAATTCAGAGCCCCCCTTAATGACATTATAATAGAGGCCCCAGCCGGC
GTCATAGATCCTGGTGAGACACCTGAGGAGGCAGCCAGGAGAGAGCTAGAGGAGGAGGCAGGCTATTATCCAGGGGAATT
AGTGAGACTGGGCTCCTATACTCCTTCGCCAGGCTACAGCAGCGAAGTAATACACTTATATTATGCAGCCAACCTAGAGT
ACCGGGGCGCTAGACCCGAGAAGTACGAGGTCCTTGAGCCATTCAAGATACCGTTATCAGAGGCTGTTAAAATGGTTTAC
TCTGGTGTCATAAACGATATGAAAACCGCTCTCCTAATCCTCCTGTACTGCTCGAGGGGTGGATGTGCTTGA

Upstream 100 bases:

>100_bases
ATTTGAGACCTATAGGCTTACCGGCTGGCCCAAACCAGAATTTAGGCATTAAACCACCCTGCTCATTAATTAATCCACTT
ATACATCACTTATTAACCTA

Downstream 100 bases:

>100_bases
GCACCGATTTAGATACGCTCAGGAGAATCCTATCCATGAGACTGGTATTCGAGGGAGGGAGCGGCTGGGTTTCCCGGGAA
TTAATAGATGTACTCGAAGA

Product: ADP-ribose pyrophosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MEVNTMDKPLVLREELLVEGLRFNVVRRYYRKTSGDEFARDIVVFPEAVAVLPILGSHEVILLRQFRAPLNDIIIEAPAG
VIDPGETPEEAARRELEEEAGYYPGELVRLGSYTPSPGYSSEVIHLYYAANLEYRGARPEKYEVLEPFKIPLSEAVKMVY
SGVINDMKTALLILLYCSRGGCA

Sequences:

>Translated_183_residues
MEVNTMDKPLVLREELLVEGLRFNVVRRYYRKTSGDEFARDIVVFPEAVAVLPILGSHEVILLRQFRAPLNDIIIEAPAG
VIDPGETPEEAARRELEEEAGYYPGELVRLGSYTPSPGYSSEVIHLYYAANLEYRGARPEKYEVLEPFKIPLSEAVKMVY
SGVINDMKTALLILLYCSRGGCA
>Mature_183_residues
MEVNTMDKPLVLREELLVEGLRFNVVRRYYRKTSGDEFARDIVVFPEAVAVLPILGSHEVILLRQFRAPLNDIIIEAPAG
VIDPGETPEEAARRELEEEAGYYPGELVRLGSYTPSPGYSSEVIHLYYAANLEYRGARPEKYEVLEPFKIPLSEAVKMVY
SGVINDMKTALLILLYCSRGGCA

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI37594464, Length=137, Percent_Identity=35.036496350365, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788810, Length=123, Percent_Identity=35.7723577235772, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 20569; Mature: 20569

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVNTMDKPLVLREELLVEGLRFNVVRRYYRKTSGDEFARDIVVFPEAVAVLPILGSHEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCE
ILLRQFRAPLNDIIIEAPAGVIDPGETPEEAARRELEEEAGYYPGELVRLGSYTPSPGYS
EEHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
SEVIHLYYAANLEYRGARPEKYEVLEPFKIPLSEAVKMVYSGVINDMKTALLILLYCSRG
CCEEEEEEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GCA
CCC
>Mature Secondary Structure
MEVNTMDKPLVLREELLVEGLRFNVVRRYYRKTSGDEFARDIVVFPEAVAVLPILGSHEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCE
ILLRQFRAPLNDIIIEAPAGVIDPGETPEEAARRELEEEAGYYPGELVRLGSYTPSPGYS
EEHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
SEVIHLYYAANLEYRGARPEKYEVLEPFKIPLSEAVKMVYSGVINDMKTALLILLYCSRG
CCEEEEEEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GCA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]