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The map label for this gene is pyrC [H]

Identifier: 218883936

GI number: 218883936

Start: 596188

End: 597519

Strand: Direct

Name: pyrC [H]

Synonym: DKAM_0625

Alternate gene names: 218883936

Gene position: 596188-597519 (Clockwise)

Preceding gene: 218883935

Following gene: 218883937

Centisome position: 43.67

GC content: 43.24

Gene sequence:

>1332_bases
TTGACGCTACTCGTTAAGAATGCCGGCATCCCTTTACCATCAGGGGATATAGTGGTTGGCAACATATATATTGAGGACGG
TGTTATCACTTATATTGGTAGGAAAGAGATACAGGCTGACAGAGTCATCAACGCTGAAGAGAGATTAACTATACCTGGAG
GCATAGACATACATGCCCATATATATGATCCGGCTTACACTAGCAATGAAGACTGGGAGACAGGTAGTCTAGCAGCCGCA
TTCGGTGGTTTAACAACAATAGTTGATATGCCTCTCAGAACAATTGTTGATAACAGGAAAATCCTTGAGGAGAAGCTGAG
TGAGGCTAGGAAGAACTCATATATAAACTATGGTGTGACAGGCGGCTTCATTAATGAGAAGAACTATAATTCTATACCCG
AGTTAGCACGATATGGTGTTAAAACATTCAAGTTCTTCACATGTAGACCATTCAAAATAAGCGATGAAGCATTACCCGAT
GCCTTCGAACAAGTGGCTGTTGCTAATGGAGTCGCAATAGTGCATGCTGAAGACGAGTCATTGATAGGATACTGGGAGAA
GAAGCTGTTATCGCAGAACAGCATCGCGGCGTTTCACTTAAGTAGGACAGGCGCCACCGAGGCTTCAGCAATATATAGAG
TCGGCTATATAAGCATAGATGTAGGTGCAAGGGTGCATATCGCCCATCTCTCCAGCAGAGAGGGGATTGAGGCTGTTGCA
GTCCTTAGGAAGAAGATTGGTTTAACTAGTGAGGTAACGCCTCACCACTTATTCTTCACAAGGGATGAGACATCGAGGTT
TGGAGCATACCTTAAAGTAGCCCCCACGATTAAAACAAGGGAGGATAGGGATGCATTATGGAGGGCTCTCGATGAAGGCA
TTATAGACGCATATGTAAGTGATAATGCTCCAGCACCTAGAAGCATGAAGGAGGCTAATGTATGGGAGGCATGGGCCGGT
ATCCCTAATCTGGAGATAATGATTCCATTCTTATTTACATATGGTATTCTCCAAAGACGTATCTCGCTAGCTAGATTCAT
AGATGTTACATCAAGGAATCCGGCTAAAATACTTGGCATCTACCCCTTAAAGGGTGAGTTATCGATTGGCAGTCATGCTG
ACCTAGTGATTCTTGAGACAGGAAAGTCTAAGAGAATAACTGCTTCAACCCATCATCATAAAGTTGATTGGACCCCATGG
GAGGGCATGGAATTGTATGGCTATCCATATTACCTAATAGTAAATGGGGAAGTAATCATAGAAAAATATGAGCTCATAGG
TAAAAAAGGCTTTGGAACATATATTGGCGAGTTAAAGCCGAGGAAGAGGTAG

Upstream 100 bases:

>100_bases
GCCCGTGTTTTATAGCTGGGTGGTTGACTACTTGGTCTCAGTATTTAAATAGTTTTACAATTAGGATAAAACAATTAGAA
AGCTAGGTGGTGTTTAACTG

Downstream 100 bases:

>100_bases
TGTATTATGGATTACTTGATTATACTGCTAAGTTACTTCACACAGTTAATAGCTATAATGAATCCTTTCTCGGCTATACC
TACATTTATGTCTCTTACCG

Product: amidohydrolase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTLLVKNAGIPLPSGDIVVGNIYIEDGVITYIGRKEIQADRVINAEERLTIPGGIDIHAHIYDPAYTSNEDWETGSLAAA
FGGLTTIVDMPLRTIVDNRKILEEKLSEARKNSYINYGVTGGFINEKNYNSIPELARYGVKTFKFFTCRPFKISDEALPD
AFEQVAVANGVAIVHAEDESLIGYWEKKLLSQNSIAAFHLSRTGATEASAIYRVGYISIDVGARVHIAHLSSREGIEAVA
VLRKKIGLTSEVTPHHLFFTRDETSRFGAYLKVAPTIKTREDRDALWRALDEGIIDAYVSDNAPAPRSMKEANVWEAWAG
IPNLEIMIPFLFTYGILQRRISLARFIDVTSRNPAKILGIYPLKGELSIGSHADLVILETGKSKRITASTHHHKVDWTPW
EGMELYGYPYYLIVNGEVIIEKYELIGKKGFGTYIGELKPRKR

Sequences:

>Translated_443_residues
MTLLVKNAGIPLPSGDIVVGNIYIEDGVITYIGRKEIQADRVINAEERLTIPGGIDIHAHIYDPAYTSNEDWETGSLAAA
FGGLTTIVDMPLRTIVDNRKILEEKLSEARKNSYINYGVTGGFINEKNYNSIPELARYGVKTFKFFTCRPFKISDEALPD
AFEQVAVANGVAIVHAEDESLIGYWEKKLLSQNSIAAFHLSRTGATEASAIYRVGYISIDVGARVHIAHLSSREGIEAVA
VLRKKIGLTSEVTPHHLFFTRDETSRFGAYLKVAPTIKTREDRDALWRALDEGIIDAYVSDNAPAPRSMKEANVWEAWAG
IPNLEIMIPFLFTYGILQRRISLARFIDVTSRNPAKILGIYPLKGELSIGSHADLVILETGKSKRITASTHHHKVDWTPW
EGMELYGYPYYLIVNGEVIIEKYELIGKKGFGTYIGELKPRKR
>Mature_442_residues
TLLVKNAGIPLPSGDIVVGNIYIEDGVITYIGRKEIQADRVINAEERLTIPGGIDIHAHIYDPAYTSNEDWETGSLAAAF
GGLTTIVDMPLRTIVDNRKILEEKLSEARKNSYINYGVTGGFINEKNYNSIPELARYGVKTFKFFTCRPFKISDEALPDA
FEQVAVANGVAIVHAEDESLIGYWEKKLLSQNSIAAFHLSRTGATEASAIYRVGYISIDVGARVHIAHLSSREGIEAVAV
LRKKIGLTSEVTPHHLFFTRDETSRFGAYLKVAPTIKTREDRDALWRALDEGIIDAYVSDNAPAPRSMKEANVWEAWAGI
PNLEIMIPFLFTYGILQRRISLARFIDVTSRNPAKILGIYPLKGELSIGSHADLVILETGKSKRITASTHHHKVDWTPWE
GMELYGYPYYLIVNGEVIIEKYELIGKKGFGTYIGELKPRKR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503051, Length=445, Percent_Identity=27.4157303370787, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI62422571, Length=445, Percent_Identity=27.4157303370787, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503375, Length=450, Percent_Identity=26.8888888888889, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4503377, Length=447, Percent_Identity=25.9507829977629, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4503379, Length=438, Percent_Identity=25.5707762557078, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI19923821, Length=439, Percent_Identity=25.9681093394077, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI18105007, Length=434, Percent_Identity=25.1152073732719, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI190194363, Length=445, Percent_Identity=24.9438202247191, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=29.954954954955, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87082175, Length=455, Percent_Identity=27.2527472527473, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17539558, Length=467, Percent_Identity=26.9807280513919, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71989490, Length=459, Percent_Identity=23.9651416122004, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=443, Percent_Identity=26.1851015801354, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI86575075, Length=441, Percent_Identity=24.4897959183673, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=440, Percent_Identity=28.6363636363636, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221377917, Length=445, Percent_Identity=28.0898876404494, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17137462, Length=437, Percent_Identity=28.604118993135, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24642586, Length=393, Percent_Identity=25.4452926208651, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18859883, Length=435, Percent_Identity=24.1379310344828, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644287, Length=232, Percent_Identity=31.0344827586207, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644289, Length=215, Percent_Identity=31.6279069767442, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49446; Mature: 49315

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLVKNAGIPLPSGDIVVGNIYIEDGVITYIGRKEIQADRVINAEERLTIPGGIDIHAH
CEEEEECCCCCCCCCCEEEEEEEEECCEEEEECCCHHCHHHEECCCCCEECCCCCEEEEE
IYDPAYTSNEDWETGSLAAAFGGLTTIVDMPLRTIVDNRKILEEKLSEARKNSYINYGVT
EECCCCCCCCCCCCCCHHHHHCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCC
GGFINEKNYNSIPELARYGVKTFKFFTCRPFKISDEALPDAFEQVAVANGVAIVHAEDES
CCEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
LIGYWEKKLLSQNSIAAFHLSRTGATEASAIYRVGYISIDVGARVHIAHLSSREGIEAVA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCCHHHHH
VLRKKIGLTSEVTPHHLFFTRDETSRFGAYLKVAPTIKTREDRDALWRALDEGIIDAYVS
HHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEC
DNAPAPRSMKEANVWEAWAGIPNLEIMIPFLFTYGILQRRISLARFIDVTSRNPAKILGI
CCCCCCCCCHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
YPLKGELSIGSHADLVILETGKSKRITASTHHHKVDWTPWEGMELYGYPYYLIVNGEVII
EECCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCEEEEECCEEEE
EKYELIGKKGFGTYIGELKPRKR
EEEHHHCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TLLVKNAGIPLPSGDIVVGNIYIEDGVITYIGRKEIQADRVINAEERLTIPGGIDIHAH
EEEEECCCCCCCCCCEEEEEEEEECCEEEEECCCHHCHHHEECCCCCEECCCCCEEEEE
IYDPAYTSNEDWETGSLAAAFGGLTTIVDMPLRTIVDNRKILEEKLSEARKNSYINYGVT
EECCCCCCCCCCCCCCHHHHHCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCC
GGFINEKNYNSIPELARYGVKTFKFFTCRPFKISDEALPDAFEQVAVANGVAIVHAEDES
CCEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
LIGYWEKKLLSQNSIAAFHLSRTGATEASAIYRVGYISIDVGARVHIAHLSSREGIEAVA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCCHHHHH
VLRKKIGLTSEVTPHHLFFTRDETSRFGAYLKVAPTIKTREDRDALWRALDEGIIDAYVS
HHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEC
DNAPAPRSMKEANVWEAWAGIPNLEIMIPFLFTYGILQRRISLARFIDVTSRNPAKILGI
CCCCCCCCCHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
YPLKGELSIGSHADLVILETGKSKRITASTHHHKVDWTPWEGMELYGYPYYLIVNGEVII
EECCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCEEEEECCEEEE
EKYELIGKKGFGTYIGELKPRKR
EEEHHHCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]