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The map label for this gene is gltT [H]

Identifier: 218883895

GI number: 218883895

Start: 545746

End: 546993

Strand: Reverse

Name: gltT [H]

Synonym: DKAM_0584

Alternate gene names: 218883895

Gene position: 546993-545746 (Counterclockwise)

Preceding gene: 218883896

Following gene: 218883894

Centisome position: 40.07

GC content: 45.83

Gene sequence:

>1248_bases
ATGAGCGCCTCCCCAAGAAGAGGAGCATATAGGTTCTTAATAGCTATATTGCTAGCGTTCTGTATAGGTACAGTGTTTGG
TTACATTACAAGCATTACCGTTCCAAAAGACACAGCGTCCACTATTGCATCATGGCTAAAGGCATTAGGAGACATATTCG
TTAGGTTAATCAGGATAATTATCCCACCCCTTATATTATTCACTATTGCAGCCGCAACATCCTCTATAGCAAGTGCCAGA
CGGCTGGGCAGGATATTAGCGGTAATACTGTTCCTCTATATTATCACCTCAATCCTTGCCGCCTTCTGGGGCGTCCTTGG
TGGAGTATTATTCCAACCCGGTATTGGGGTGGGTCTCCAACCACCTAAGGGCTACCAGCCTCCAACCCCTCCAAGCGGGC
CGGATCTACTGCTTTCATTCTTCATGCCCGACTTTGTAAACCTCTTAACCGTCTCCGGTTCTATGACGATGATAATTTTC
GCTATAATACTGGGTGTCGCAGTAGTATTTATGGGGGAGCCAGGCAGGAAGATAGCTTCAATGCTCTCACTCTTATCAAC
CCTCATGGTTAAATTCGTATCAGTTATAATGTACTATGCACCGATAGCTGTGTTCAGCTATGCTGGCTGGCTGATGATAT
CCTACGGACCAGCCATGCTGGGTGCTTACGCGAAATTCCTTGGTGTACAATACGGGTTCACACTATTCCATTTCATTGTA
ATATATTCTATAATAGTCATGCTAGGAGGGCTTAACCCTATAGTATACTTTAAGGCTCAGCTAACACCTTTCCTAATAGC
TTTCACAACCCGTTCATCAGCTGTAACACTCCCATTCAACATGGAGGCCGCTAGGAAAATGGGTGTGTCCGATGAAGTAT
TCAATATAACGCTCCCCATAGGCGCTACCGTTAACATGGATGTGACAGCCTTATACCAGGCGCTCAGCGCCTTATTCATC
TCGCAGTTATTCGGCATAAATCTAACATCAACCCAGCTAGGCATGGTCGTAATGGCGGCCCTTATTGGATCAGTGGCCAC
AGCTGCTATACCTGGTGGCGGGACAATAATGCTTGCATATGTGTTATCCGTGATTGGCCTACCCTTAGAAGGTGTTGGTA
TAATGATGGTTATCGATCCATTAGCTGATACTATAAGGACGGCTGTAAACGTGTCGGATGATAATGCGTGCACCATACTG
ATAACGAAGTTAACCGGGTATAGGCTGAATCCAAAGACCGGCTCTTGA

Upstream 100 bases:

>100_bases
TTGCCAAGTGGAATCCAAGAAAGAAAGTGTTTGAGAATATATATGATCTAGGCATATACCTGAGGTTACTTGGTTAGTGT
ATATACTTAGATGAATTACA

Downstream 100 bases:

>100_bases
CAGCACAGCAGCGATACAGTGTAGACAGCGTTTACCGGATGACCCCAATTAATTTTCCCAATTATTATTTTTAAAGTGAA
ACATTGGTGGGTTAGAAATA

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSASPRRGAYRFLIAILLAFCIGTVFGYITSITVPKDTASTIASWLKALGDIFVRLIRIIIPPLILFTIAAATSSIASAR
RLGRILAVILFLYIITSILAAFWGVLGGVLFQPGIGVGLQPPKGYQPPTPPSGPDLLLSFFMPDFVNLLTVSGSMTMIIF
AIILGVAVVFMGEPGRKIASMLSLLSTLMVKFVSVIMYYAPIAVFSYAGWLMISYGPAMLGAYAKFLGVQYGFTLFHFIV
IYSIIVMLGGLNPIVYFKAQLTPFLIAFTTRSSAVTLPFNMEAARKMGVSDEVFNITLPIGATVNMDVTALYQALSALFI
SQLFGINLTSTQLGMVVMAALIGSVATAAIPGGGTIMLAYVLSVIGLPLEGVGIMMVIDPLADTIRTAVNVSDDNACTIL
ITKLTGYRLNPKTGS

Sequences:

>Translated_415_residues
MSASPRRGAYRFLIAILLAFCIGTVFGYITSITVPKDTASTIASWLKALGDIFVRLIRIIIPPLILFTIAAATSSIASAR
RLGRILAVILFLYIITSILAAFWGVLGGVLFQPGIGVGLQPPKGYQPPTPPSGPDLLLSFFMPDFVNLLTVSGSMTMIIF
AIILGVAVVFMGEPGRKIASMLSLLSTLMVKFVSVIMYYAPIAVFSYAGWLMISYGPAMLGAYAKFLGVQYGFTLFHFIV
IYSIIVMLGGLNPIVYFKAQLTPFLIAFTTRSSAVTLPFNMEAARKMGVSDEVFNITLPIGATVNMDVTALYQALSALFI
SQLFGINLTSTQLGMVVMAALIGSVATAAIPGGGTIMLAYVLSVIGLPLEGVGIMMVIDPLADTIRTAVNVSDDNACTIL
ITKLTGYRLNPKTGS
>Mature_414_residues
SASPRRGAYRFLIAILLAFCIGTVFGYITSITVPKDTASTIASWLKALGDIFVRLIRIIIPPLILFTIAAATSSIASARR
LGRILAVILFLYIITSILAAFWGVLGGVLFQPGIGVGLQPPKGYQPPTPPSGPDLLLSFFMPDFVNLLTVSGSMTMIIFA
IILGVAVVFMGEPGRKIASMLSLLSTLMVKFVSVIMYYAPIAVFSYAGWLMISYGPAMLGAYAKFLGVQYGFTLFHFIVI
YSIIVMLGGLNPIVYFKAQLTPFLIAFTTRSSAVTLPFNMEAARKMGVSDEVFNITLPIGATVNMDVTALYQALSALFIS
QLFGINLTSTQLGMVVMAALIGSVATAAIPGGGTIMLAYVLSVIGLPLEGVGIMMVIDPLADTIRTAVNVSDDNACTILI
TKLTGYRLNPKTGS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=403, Percent_Identity=27.2952853598015, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4827012, Length=262, Percent_Identity=30.5343511450382, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI223468564, Length=244, Percent_Identity=33.6065573770492, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI223468566, Length=244, Percent_Identity=33.6065573770492, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI169790839, Length=268, Percent_Identity=28.3582089552239, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI5032093, Length=246, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI66773030, Length=267, Percent_Identity=31.8352059925094, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI40254478, Length=246, Percent_Identity=30.8943089430894, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI194239697, Length=242, Percent_Identity=30.1652892561983, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI301601644, Length=122, Percent_Identity=36.8852459016393, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262359914, Length=189, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790514, Length=416, Percent_Identity=25.9615384615385, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789947, Length=388, Percent_Identity=27.5773195876289, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788024, Length=398, Percent_Identity=26.6331658291457, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789473, Length=368, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71996953, Length=421, Percent_Identity=26.8408551068884, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537407, Length=400, Percent_Identity=25.75, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71983099, Length=401, Percent_Identity=24.6882793017456, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=401, Percent_Identity=24.6882793017456, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=408, Percent_Identity=24.0196078431373, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=410, Percent_Identity=26.0975609756098, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193206654, Length=408, Percent_Identity=23.7745098039216, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583025, Length=402, Percent_Identity=26.865671641791, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17137668, Length=402, Percent_Identity=26.865671641791, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24583023, Length=402, Percent_Identity=26.865671641791, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281360483, Length=422, Percent_Identity=23.4597156398104, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137666, Length=422, Percent_Identity=23.4597156398104, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281360481, Length=422, Percent_Identity=23.4597156398104, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44252; Mature: 44121

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCCCCC
>Mature Secondary Structure 
SASPRRGAYRFLIAILLAFCIGTVFGYITSITVPKDTASTIASWLKALGDIFVRLIRII
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IPPLILFTIAAATSSIASARRLGRILAVILFLYIITSILAAFWGVLGGVLFQPGIGVGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PPKGYQPPTPPSGPDLLLSFFMPDFVNLLTVSGSMTMIIFAIILGVAVVFMGEPGRKIAS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
MLSLLSTLMVKFVSVIMYYAPIAVFSYAGWLMISYGPAMLGAYAKFLGVQYGFTLFHFIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHH
IYSIIVMLGGLNPIVYFKAQLTPFLIAFTTRSSAVTLPFNMEAARKMGVSDEVFNITLPI
HHHHHHHHCCCCHHEEEEEHHCEEEEEEECCCCEEEECCCHHHHHHCCCCCCEEEEEECC
GATVNMDVTALYQALSALFISQLFGINLTSTQLGMVVMAALIGSVATAAIPGGGTIMLAY
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VLSVIGLPLEGVGIMMVIDPLADTIRTAVNVSDDNACTILITKLTGYRLNPKTGS
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEEECCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]