Click here to switch to the map view.

The map label for this gene is rnz [H]

Identifier: 218883849

GI number: 218883849

Start: 504569

End: 505318

Strand: Reverse

Name: rnz [H]

Synonym: DKAM_0538

Alternate gene names: 218883849

Gene position: 505318-504569 (Counterclockwise)

Preceding gene: 218883850

Following gene: 218883848

Centisome position: 37.01

GC content: 48.27

Gene sequence:

>750_bases
ATGAGCACTAAAGTATTCTTCCTAGGTACCGGGGCAGCGATACCGGTTACCAGGGGGCTCCCTTGTATCGCCCTAAGAGT
GGATTCAAACATATACCTACTAGACGTAGGCGAGGGATGCCAGTCAAGGATGTTTAAAGCTGGTTTAAGCCCCATCAAGG
TGAAGGCTGTCTTCGTAACCCACCCCCATGGAGACCACTATCTCGGGCTCTTCGGGCTTCTCCAGACAATGGGTTTGATG
GATAGGAAAGAGGCTCTTAAACTAGTTGTCCCAAAAGAGGTGGAAGAGCATATCAAGGTCGTAGTCGAGAAGAAGTTGAT
GAGAACGGTCTTCCCCCTTGAGCTAACCGTGATAACCAGTGGCGAGGTCTATCGTGATGAGAAGATCAGCGTGGAAGCAT
ACCCGGTTCAACACGGTGTGGAAGCATATGGGTTCCGTGTTGGAATAGGTAAGAAATCACTGTGCTATACCGGGGACACT
ATGCCCTGTAATACTATTGTTGAGAACTGCAAAGGAGTAGATGTATTGATCCATGAGTCAACGTTTACGAGTGAGATGAG
TAGTGAGGCACATGAGGAGTATCATTCAACATCTAAGGATGCAGCCCTGACAGCCATCGAAGCCGGGGTTGCATCCCTTG
TGTTGACACATATAAGTGCGAGGCATAGTGATGAGGAAGTATTGAGGGATGCATTGAGATTCTTCTCAAACACTATTGTT
GCCCGCGACTTCTCAATCCTCTACCTGTGA

Upstream 100 bases:

>100_bases
GTGGGTGAGCTGCTATGCCGCAACGGTTTCACCGAGGTATCAAGGTATTATCAATACGTTCATGGAGGGCTTACAAGAGT
AATCTACGTAGTGAGAAAGA

Downstream 100 bases:

>100_bases
TCTCCTCTCCGCTCTAAGGTGTGGGCTGAAGTCTTTTTGGTGTTTAGAGGAGGGGTTTATACTGGGTTGATAGGCGACAA
TGGATATGGATCCCAGCCTA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSTKVFFLGTGAAIPVTRGLPCIALRVDSNIYLLDVGEGCQSRMFKAGLSPIKVKAVFVTHPHGDHYLGLFGLLQTMGLM
DRKEALKLVVPKEVEEHIKVVVEKKLMRTVFPLELTVITSGEVYRDEKISVEAYPVQHGVEAYGFRVGIGKKSLCYTGDT
MPCNTIVENCKGVDVLIHESTFTSEMSSEAHEEYHSTSKDAALTAIEAGVASLVLTHISARHSDEEVLRDALRFFSNTIV
ARDFSILYL

Sequences:

>Translated_249_residues
MSTKVFFLGTGAAIPVTRGLPCIALRVDSNIYLLDVGEGCQSRMFKAGLSPIKVKAVFVTHPHGDHYLGLFGLLQTMGLM
DRKEALKLVVPKEVEEHIKVVVEKKLMRTVFPLELTVITSGEVYRDEKISVEAYPVQHGVEAYGFRVGIGKKSLCYTGDT
MPCNTIVENCKGVDVLIHESTFTSEMSSEAHEEYHSTSKDAALTAIEAGVASLVLTHISARHSDEEVLRDALRFFSNTIV
ARDFSILYL
>Mature_248_residues
STKVFFLGTGAAIPVTRGLPCIALRVDSNIYLLDVGEGCQSRMFKAGLSPIKVKAVFVTHPHGDHYLGLFGLLQTMGLMD
RKEALKLVVPKEVEEHIKVVVEKKLMRTVFPLELTVITSGEVYRDEKISVEAYPVQHGVEAYGFRVGIGKKSLCYTGDTM
PCNTIVENCKGVDVLIHESTFTSEMSSEAHEEYHSTSKDAALTAIEAGVASLVLTHISARHSDEEVLRDALRFFSNTIVA
RDFSILYL

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=327, Percent_Identity=25.9938837920489, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI87082078, Length=302, Percent_Identity=30.4635761589404, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985808, Length=283, Percent_Identity=27.208480565371, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985814, Length=283, Percent_Identity=27.208480565371, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652403, Length=271, Percent_Identity=28.7822878228782, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 27466; Mature: 27335

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKVFFLGTGAAIPVTRGLPCIALRVDSNIYLLDVGEGCQSRMFKAGLSPIKVKAVFVT
CCCEEEEEECCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHCCCCEEEEEEEEE
HPHGDHYLGLFGLLQTMGLMDRKEALKLVVPKEVEEHIKVVVEKKLMRTVFPLELTVITS
CCCCCCHHHHHHHHHHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
GEVYRDEKISVEAYPVQHGVEAYGFRVGIGKKSLCYTGDTMPCNTIVENCKGVDVLIHES
CCEEECCEEEEEEECHHCCHHHHEEEEECCCCCEEECCCCCCHHHHHHCCCCCEEEEECC
TFTSEMSSEAHEEYHSTSKDAALTAIEAGVASLVLTHISARHSDEEVLRDALRFFSNTIV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ARDFSILYL
EECEEEEEC
>Mature Secondary Structure 
STKVFFLGTGAAIPVTRGLPCIALRVDSNIYLLDVGEGCQSRMFKAGLSPIKVKAVFVT
CCEEEEEECCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHCCCCEEEEEEEEE
HPHGDHYLGLFGLLQTMGLMDRKEALKLVVPKEVEEHIKVVVEKKLMRTVFPLELTVITS
CCCCCCHHHHHHHHHHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
GEVYRDEKISVEAYPVQHGVEAYGFRVGIGKKSLCYTGDTMPCNTIVENCKGVDVLIHES
CCEEECCEEEEEEECHHCCHHHHEEEEECCCCCEEECCCCCCHHHHHHCCCCCEEEEECC
TFTSEMSSEAHEEYHSTSKDAALTAIEAGVASLVLTHISARHSDEEVLRDALRFFSNTIV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ARDFSILYL
EECEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]