Click here to switch to the map view.

The map label for this gene is htpX [H]

Identifier: 218883669

GI number: 218883669

Start: 331027

End: 332127

Strand: Reverse

Name: htpX [H]

Synonym: DKAM_0358

Alternate gene names: 218883669

Gene position: 332127-331027 (Counterclockwise)

Preceding gene: 218883670

Following gene: 218883667

Centisome position: 24.33

GC content: 43.14

Gene sequence:

>1101_bases
ATGATAGCGCTTATAATAGTATACATTATTGGATTCCTAGTATTAATGGTTACAGCTGGCTATATTGCCCCAAAGGTGGC
ACGTAGGTTCGCCAGTAGATTCTCCCTCTCATCATCCATGTTGCTGATAGGCCTCCTAACTATTGGATCGAGTATTGCAG
GGATATCGCTTGTAGCATATGTATTAATTAACTATATTGGTGCAGAGTTCACGCTGGGCTTCATTGTATGGCTCGTGATC
TTCATAGTGATAGCCAATATGTTCACATATATTCTCTCGCCCTACATGATAAACCTTCTCTACGGGGCTAGACACGATGA
ATGGTTGCAGAAGGTAGTTGATGAGGTAGCATTAAGGCTCGGTTTAAGTAACCCACCTAAGGCAATGATTGTAAATATAC
CTCCAAACGCGTTTGCCTATGGTAACGCTTTGTCAGGTAGATACGTGGCTGTGTCAAGGGAGCTTATCGAGATGCTTAAC
GAGGATGAATTAAGGGCTGTAATAGGGCATGAGCTGGGCCATCATTTACACAGGGATAACTCTATAATGTTATTCATGGG
GCTACTGCCCAGCATCATATATTATCTAGGTGTCTCCCTGATAAGGGCAGGCATAATTTACTCGTCAATGAGGCTTACAT
CGGAGAGGAAGAATAGTGGTTCAGGGGGCTTCATATTAGCTATAATAGGTATATTAGCAGTGGTAATAAGCTTCATTGTT
CAAATACTCGTACTAGCCTTTAGCAGGCTCAGGGAATACTATGCAGACACTACTGGAGCTTATGCTTCGTCCCCATCGAA
CATGCAGAGGGCGCTTGCAAAACTACACATATACTATGAGGGCAGCGGGAGAGCCCGAGAAATGGTTTCAACAAGTAAGT
TGAGAACAATGTTCATATACGCCTTCACAGAGGCGGTGGCTAACCCATTATACCACTATGGTTCATTCTATAGAAGTCCT
AAGATAGATGACGCAAGCATAGATGAAGTAATACAGGAGCTCAAGAATAAAGAAGTGAATAGCATGCAGGAATTCCTCTC
AACACACCCCCCAATACCCAAGAGGCTCCGTTTCCTTGATGAATTAGTTTTTAAGGCGTAG

Upstream 100 bases:

>100_bases
GACGCTTATAAACCAGTTTTCTCAAGTTTTTAAGGATGTCTTCGATTATATTATTACCTGGTGATTATCGATGTTGCTAT
GGTTTTATGATCCCTTTACG

Downstream 100 bases:

>100_bases
GCGTCTCGGTGGGTATTTTGGATCCTATATCTTTTATCCCCATGTTAGCCACTATGGCCCTGATAGACTCGGTGGACCCG
TGCTTCTTCATATTATACAC

Product: putative protease htpX-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MIALIIVYIIGFLVLMVTAGYIAPKVARRFASRFSLSSSMLLIGLLTIGSSIAGISLVAYVLINYIGAEFTLGFIVWLVI
FIVIANMFTYILSPYMINLLYGARHDEWLQKVVDEVALRLGLSNPPKAMIVNIPPNAFAYGNALSGRYVAVSRELIEMLN
EDELRAVIGHELGHHLHRDNSIMLFMGLLPSIIYYLGVSLIRAGIIYSSMRLTSERKNSGSGGFILAIIGILAVVISFIV
QILVLAFSRLREYYADTTGAYASSPSNMQRALAKLHIYYEGSGRAREMVSTSKLRTMFIYAFTEAVANPLYHYGSFYRSP
KIDDASIDEVIQELKNKEVNSMQEFLSTHPPIPKRLRFLDELVFKA

Sequences:

>Translated_366_residues
MIALIIVYIIGFLVLMVTAGYIAPKVARRFASRFSLSSSMLLIGLLTIGSSIAGISLVAYVLINYIGAEFTLGFIVWLVI
FIVIANMFTYILSPYMINLLYGARHDEWLQKVVDEVALRLGLSNPPKAMIVNIPPNAFAYGNALSGRYVAVSRELIEMLN
EDELRAVIGHELGHHLHRDNSIMLFMGLLPSIIYYLGVSLIRAGIIYSSMRLTSERKNSGSGGFILAIIGILAVVISFIV
QILVLAFSRLREYYADTTGAYASSPSNMQRALAKLHIYYEGSGRAREMVSTSKLRTMFIYAFTEAVANPLYHYGSFYRSP
KIDDASIDEVIQELKNKEVNSMQEFLSTHPPIPKRLRFLDELVFKA
>Mature_366_residues
MIALIIVYIIGFLVLMVTAGYIAPKVARRFASRFSLSSSMLLIGLLTIGSSIAGISLVAYVLINYIGAEFTLGFIVWLVI
FIVIANMFTYILSPYMINLLYGARHDEWLQKVVDEVALRLGLSNPPKAMIVNIPPNAFAYGNALSGRYVAVSRELIEMLN
EDELRAVIGHELGHHLHRDNSIMLFMGLLPSIIYYLGVSLIRAGIIYSSMRLTSERKNSGSGGFILAIIGILAVVISFIV
QILVLAFSRLREYYADTTGAYASSPSNMQRALAKLHIYYEGSGRAREMVSTSKLRTMFIYAFTEAVANPLYHYGSFYRSP
KIDDASIDEVIQELKNKEVNSMQEFLSTHPPIPKRLRFLDELVFKA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=178, Percent_Identity=27.5280898876405, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 40890; Mature: 40890

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALIIVYIIGFLVLMVTAGYIAPKVARRFASRFSLSSSMLLIGLLTIGSSIAGISLVAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
VLINYIGAEFTLGFIVWLVIFIVIANMFTYILSPYMINLLYGARHDEWLQKVVDEVALRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLSNPPKAMIVNIPPNAFAYGNALSGRYVAVSRELIEMLNEDELRAVIGHELGHHLHRDN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
SIMLFMGLLPSIIYYLGVSLIRAGIIYSSMRLTSERKNSGSGGFILAIIGILAVVISFIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
QILVLAFSRLREYYADTTGAYASSPSNMQRALAKLHIYYEGSGRAREMVSTSKLRTMFIY
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHH
AFTEAVANPLYHYGSFYRSPKIDDASIDEVIQELKNKEVNSMQEFLSTHPPIPKRLRFLD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
ELVFKA
HHHHCC
>Mature Secondary Structure
MIALIIVYIIGFLVLMVTAGYIAPKVARRFASRFSLSSSMLLIGLLTIGSSIAGISLVAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
VLINYIGAEFTLGFIVWLVIFIVIANMFTYILSPYMINLLYGARHDEWLQKVVDEVALRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GLSNPPKAMIVNIPPNAFAYGNALSGRYVAVSRELIEMLNEDELRAVIGHELGHHLHRDN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
SIMLFMGLLPSIIYYLGVSLIRAGIIYSSMRLTSERKNSGSGGFILAIIGILAVVISFIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
QILVLAFSRLREYYADTTGAYASSPSNMQRALAKLHIYYEGSGRAREMVSTSKLRTMFIY
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHH
AFTEAVANPLYHYGSFYRSPKIDDASIDEVIQELKNKEVNSMQEFLSTHPPIPKRLRFLD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
ELVFKA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]