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The map label for this gene is coaBC [H]

Identifier: 218883643

GI number: 218883643

Start: 306184

End: 307404

Strand: Direct

Name: coaBC [H]

Synonym: DKAM_0332

Alternate gene names: 218883643

Gene position: 306184-307404 (Clockwise)

Preceding gene: 218883638

Following gene: 218883644

Centisome position: 22.43

GC content: 48.16

Gene sequence:

>1221_bases
TTGGCCCATGAAGAGCTTACAAGGTTTCTCCATCAACCCCTCCAGGGTAGGAACATACTGCTCGGCTTAACGGCTAGCTC
ATCAATATATAAATCAATAGACCTCGCCAGGAGACTCATACGTATGGGGGGCAATCTTAGAGTTGTAATGACGAGGAGAT
CGCTTTCACTCATAGGTGTGGACCTAGTTCACTGGGCTACCGGTAGTAAACCATTCTACGAGATGAGCGGGGAAACAGAG
CATATAGATCTAGCACAATGGGCTGACGCAATGGTTATCGCGCCTGCAACACTGAACACTATGGGGAAGATCGCGTACGG
TATACTTGATGAACTACTAACACTAACAGCCACCACGATGATGGGGTCTAGTAAGAAGGTGATAATAGTGCCAGCAATGA
ACATCCGCTTAATGAGCTCTCCCCAATACAAGAACGCTGCTGGAAAACTAGAGGAATATGGGGCTGTGATAATACCTCCG
TTAATAGAAGAGGATAAAGCCAAGTATCCTCCCCTAGATGACTTATCCCACTGCATAGACGCCATAGTTAACAGGGGAGT
AGACTTAAAGAACCGGAGGATACTAGTTACCGCGGGACCGACAAGGGAATACCTAGACCCGGTGAGGGTAATAACCAATC
CAAGCAGCGGATTGATGGGTGTCCTAATAGCCAGGGAACTGGCTTGCAGAGGAGCCAGGGTAGACCTGGTACACGGCCCG
ATGACTGTGAAACCCCCATACCTTGTTAAAAGCATCCATGTCGAGACAACGAGTGATATGGCTGATAAAATACGGGAGCT
AACAAATGAGACAATATATGATGCAGCAGTATTCGCGGCTGCCCCAGCAGACTATAAACCGGCTTCTTCATCACCGGAGA
AGATATCGACCAGGGATAAACCATACCTTGAGGTAAGACTGGAGCAAACCCCGAAAACCATTAAATCCATTGCCAATAGG
CCAAGGATACTCGTAGCATTCGCTGCTGAAACATGTGGTGGCGAGAAGCTTGTTGAGAAAACCCTTCTGAAGGCAAGTGA
TTATGGAGCTGACCTCGTCATAGGTAACAACGTGTTATCGAGTGAAGCCGGTTTCGGGAAGGAGATGCTCGAGATCGTTG
CAGTGGCTGAAGGAGGCATCATGGATAGAGGCACCAGGTTTAAACCCGAGGTCGCCAGGATAATAGGAGACTTTATATCG
AGGAGACTTCAAGCCTGTTGA

Upstream 100 bases:

>100_bases
ACGAGGTAACCGTGCTCATAGCCATGACCCTAAGTGTATTAAAGCCCCTCGTATGATTTATAAATAGTGTTTAAGGTATC
AAGCCTAATCGGGGATTTAA

Downstream 100 bases:

>100_bases
GGGTTCTAAATACTTTCTGAATTCCTTGTAGATGTTTTGGATGTGTTTGTTCTCTTGATGTCTTCACTAGTTTTCCTTGA
TGACTATTACTTTTATTTTT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAHEELTRFLHQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETE
HIDLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP
LIEEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGP
MTVKPPYLVKSIHVETTSDMADKIRELTNETIYDAAVFAAAPADYKPASSSPEKISTRDKPYLEVRLEQTPKTIKSIANR
PRILVAFAAETCGGEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFIS
RRLQAC

Sequences:

>Translated_406_residues
MAHEELTRFLHQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETE
HIDLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP
LIEEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGP
MTVKPPYLVKSIHVETTSDMADKIRELTNETIYDAAVFAAAPADYKPASSSPEKISTRDKPYLEVRLEQTPKTIKSIANR
PRILVAFAAETCGGEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFIS
RRLQAC
>Mature_405_residues
AHEELTRFLHQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETEH
IDLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPL
IEEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPM
TVKPPYLVKSIHVETTSDMADKIRELTNETIYDAAVFAAAPADYKPASSSPEKISTRDKPYLEVRLEQTPKTIKSIANRP
RILVAFAAETCGGEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFISR
RLQAC

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=155, Percent_Identity=33.5483870967742, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082301, Length=388, Percent_Identity=29.639175257732, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44428; Mature: 44297

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHEELTRFLHQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGV
CCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHH
DLVHWATGSKPFYEMSGETEHIDLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTM
HHEEECCCCCCCEECCCCCCEEEHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
MGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPLIEEDKAKYPPLDDLSHCID
CCCCCCEEEEECCCEEEECCCCCCCHHCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHH
AIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGP
HHHHCCCCCCCCEEEEEECCCHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
MTVKPPYLVKSIHVETTSDMADKIRELTNETIYDAAVFAAAPADYKPASSSPEKISTRDK
EECCCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PYLEVRLEQTPKTIKSIANRPRILVAFAAETCGGEKLVEKTLLKASDYGADLVIGNNVLS
CEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEC
SEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFISRRLQAC
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHEELTRFLHQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGV
CHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHH
DLVHWATGSKPFYEMSGETEHIDLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTM
HHEEECCCCCCCEECCCCCCEEEHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
MGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPLIEEDKAKYPPLDDLSHCID
CCCCCCEEEEECCCEEEECCCCCCCHHCCHHHCCCEEECCCCCCCCCCCCCHHHHHHHHH
AIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGP
HHHHCCCCCCCCEEEEEECCCHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
MTVKPPYLVKSIHVETTSDMADKIRELTNETIYDAAVFAAAPADYKPASSSPEKISTRDK
EECCCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PYLEVRLEQTPKTIKSIANRPRILVAFAAETCGGEKLVEKTLLKASDYGADLVIGNNVLS
CEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEC
SEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFISRRLQAC
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]