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The map label for this gene is pcn [H]

Identifier: 218883636

GI number: 218883636

Start: 298364

End: 299104

Strand: Direct

Name: pcn [H]

Synonym: DKAM_0325

Alternate gene names: 218883636

Gene position: 298364-299104 (Clockwise)

Preceding gene: 218883635

Following gene: 218883637

Centisome position: 21.85

GC content: 44.4

Gene sequence:

>741_bases
ATGGTGAGGATGGTTTTACCTGAAGCGAAAATATTCAGGAAAATAATCGAGTCCGTTGGAAAACTGGCCGATGAAGTCGC
GTTTACAGTTACTAGTAACGGTGTCTCCCTTAAAGCACTCGACGTTGATCAATCATCCTACATCGAGGTTTTCCTACCAG
CCGATATGTTTCTCGAGTACACTGTAGATAGCGAGGAAATCCTGGGGGTTTCAATCAGCAATATCAAAAAAGTTCTAAAA
CACCTTAGGAAAGGCGAGAACCTTATCATAGAGTCAAATGGAGAGTTCATAGAGTTCACTGTCAGCAGTGTCGCGAAAAG
ACGGTTCAAGTTCAGGAACCTAGATGTCTCAGTACCCGAGATACCTGAATTCAACCTGGAATTCAAGGTATCAGCTCAAC
TAGTCTCATCAAACGTGAAGAAGGCCCTTGAAGATGTTGAGAGCGTGGGAAGCCTTATTGAGATAGATGCTCCATCAAAT
GATCTAATGGTTTTCAGGGCAGTGGGCTCTGGAAAGGTCGAGGTCAAGTTCGCAGCTGGTTCAACAGCTCTGTTATCCAT
GGATGTGAAGGAGCCGTCTAAATCCATCTATGACGTCGTAAAGCTCTCCACGATCCTCAGTATTACAGAGGTCTCAGACG
TGGTTACACTGGAATTCGCTAGTAAAATGCCTCTCAAAATGGAGTTTAAGATAGGAAACGGGAGGATATCGTATCTAACC
GCACCAATAGAGGCAGTATAG

Upstream 100 bases:

>100_bases
TTGAGGGAGACGAGAACGAGCTAGAGGAGGTAGTTAAATACTTCTCAACTTAAAATCATTTATAATTCTAGACACTAGTA
TTATTGATAGGGAGAATAAC

Downstream 100 bases:

>100_bases
TTGGAGCCCTACATACCTTTAACCATTTTCAATAATTTAACTCTGATATCAAGGAGGCTTGCTGGAGATAGGTGCATTGT
TGTCTTTTTAAATGACGTGG

Product: DNA polymerase sliding clamp A

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog; PCNA [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MVRMVLPEAKIFRKIIESVGKLADEVAFTVTSNGVSLKALDVDQSSYIEVFLPADMFLEYTVDSEEILGVSISNIKKVLK
HLRKGENLIIESNGEFIEFTVSSVAKRRFKFRNLDVSVPEIPEFNLEFKVSAQLVSSNVKKALEDVESVGSLIEIDAPSN
DLMVFRAVGSGKVEVKFAAGSTALLSMDVKEPSKSIYDVVKLSTILSITEVSDVVTLEFASKMPLKMEFKIGNGRISYLT
APIEAV

Sequences:

>Translated_246_residues
MVRMVLPEAKIFRKIIESVGKLADEVAFTVTSNGVSLKALDVDQSSYIEVFLPADMFLEYTVDSEEILGVSISNIKKVLK
HLRKGENLIIESNGEFIEFTVSSVAKRRFKFRNLDVSVPEIPEFNLEFKVSAQLVSSNVKKALEDVESVGSLIEIDAPSN
DLMVFRAVGSGKVEVKFAAGSTALLSMDVKEPSKSIYDVVKLSTILSITEVSDVVTLEFASKMPLKMEFKIGNGRISYLT
APIEAV
>Mature_246_residues
MVRMVLPEAKIFRKIIESVGKLADEVAFTVTSNGVSLKALDVDQSSYIEVFLPADMFLEYTVDSEEILGVSISNIKKVLK
HLRKGENLIIESNGEFIEFTVSSVAKRRFKFRNLDVSVPEIPEFNLEFKVSAQLVSSNVKKALEDVESVGSLIEIDAPSN
DLMVFRAVGSGKVEVKFAAGSTALLSMDVKEPSKSIYDVVKLSTILSITEVSDVVTLEFASKMPLKMEFKIGNGRISYLT
APIEAV

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication [H]

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family [H]

Homologues:

Organism=Homo sapiens, GI33239451, Length=257, Percent_Identity=24.5136186770428, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4505641, Length=257, Percent_Identity=24.5136186770428, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585303, Length=251, Percent_Identity=25.8964143426295, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136790, Length=256, Percent_Identity=22.65625, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45552759, Length=256, Percent_Identity=22.65625, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022648 [H]

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N [H]

EC number: NA

Molecular weight: Translated: 27078; Mature: 27078

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRMVLPEAKIFRKIIESVGKLADEVAFTVTSNGVSLKALDVDQSSYIEVFLPADMFLEY
CEEEECCHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEE
TVDSEEILGVSISNIKKVLKHLRKGENLIIESNGEFIEFTVSSVAKRRFKFRNLDVSVPE
ECCCHHEEEEEHHHHHHHHHHHHCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCCCC
IPEFNLEFKVSAQLVSSNVKKALEDVESVGSLIEIDAPSNDLMVFRAVGSGKVEVKFAAG
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCEEEEEEECC
STALLSMDVKEPSKSIYDVVKLSTILSITEVSDVVTLEFASKMPLKMEFKIGNGRISYLT
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEE
APIEAV
CCCCCC
>Mature Secondary Structure
MVRMVLPEAKIFRKIIESVGKLADEVAFTVTSNGVSLKALDVDQSSYIEVFLPADMFLEY
CEEEECCHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEE
TVDSEEILGVSISNIKKVLKHLRKGENLIIESNGEFIEFTVSSVAKRRFKFRNLDVSVPE
ECCCHHEEEEEHHHHHHHHHHHHCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCCCC
IPEFNLEFKVSAQLVSSNVKKALEDVESVGSLIEIDAPSNDLMVFRAVGSGKVEVKFAAG
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCEEEEEEECC
STALLSMDVKEPSKSIYDVVKLSTILSITEVSDVVTLEFASKMPLKMEFKIGNGRISYLT
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEE
APIEAV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA