Click here to switch to the map view.

The map label for this gene is galE [C]

Identifier: 218883571

GI number: 218883571

Start: 240912

End: 241907

Strand: Direct

Name: galE [C]

Synonym: DKAM_0260

Alternate gene names: 218883571

Gene position: 240912-241907 (Clockwise)

Preceding gene: 218883564

Following gene: 218883572

Centisome position: 17.65

GC content: 48.39

Gene sequence:

>996_bases
ATGAGCTTATATGATGCAGGAGAGGAATTAAGCATGAGATATGTTGTCACAGGAGGAGCGGGCTTCATAGGTAGCCACTT
AGTCGACTACCTTGTCTACAGGCTTAAAGCTGATGAGGTAGTGGTAATCGACAACTTGTCCTCAGGTTCACCCAGGAACA
TAGAGATGCATATTGATGCAGGGGTAGTGAGACTCGTTAAGGCGGATCTATCTAAGCGCGGAGAATGGGAGAAGGGCCTT
AAAGGAGCCGATATAGTTTTCCACTATGCCGCCAACCCTGAGGTCAGGATATCGAGTGTGGAGCCAGGCATACACTTCGA
GAATAACGTGGTCGCGACATTCAATGTACTGGAGGCAATGAGGCTCGGCGACGTAGATAAGCTAGTCTTTGCCAGTAGCT
CAACGGTTTACGGTGAGCCCTCGGTTATACCTACCCCCGAGGACTATCATCCGTTGAAGCCTATTTCCATATATGGTGCA
TCAAAACTGGCATCCGAGGTACTTATACAGGTGTATAGTGAGCTATACGGGTTTAAAGCACTGATACTACGCTACGCAAA
CATAATTGGGGCGAGAAGCAATCATGGAGTCATAGTTGACTTCATAAACAAGCTGAGGACAAATCCCTCCAGGCTGGAGA
TACTTGGTGATGGGACCCAGAGGAAGAGTTATCTCCATGTAAGCGACGCTGTTGAGGCCACAATGCATCTTGCTGTGAAT
AAGCTTAATAGCATGCATGGAGTAGATGTTTACAACGTGGGCAACCATGACTGGGTGACTGTGACCGAGATAGCAGATAT
AATAGTGGAGGAAATGGGTCTCGGGAGAGTTGACTACGTGTTCAAGAAGACCACTCCGGATGGGAGAGGATGGCCCGGAG
ACGTTAAATTAATGCTCCTCGACATAAGGAAGCTGGAGTCAACAGGGTGGAAGCCTAGGCTCTCTTCAAGGGACGCTGTT
AGAAGAACCGTGAGAGAACTCCTCGGCAAGACCTAA

Upstream 100 bases:

>100_bases
CCTATTTTATCAATCATGAAATCATCCTCCCAGATCCTCCATGATGAGACCCCTTGGATTTTAAACTTTGATGTAATTCT
TATTAAACCCATACCTAATA

Downstream 100 bases:

>100_bases
GCCAAAAGCCCTTCCACGAGGTTCAGGGAAACGGCAGCTGTATATGCCTTGATGAAGCTGTTGGAGGAGGGTTCGCTGAG
GGGAGACGTCGTCGTTGTCT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSLYDAGEELSMRYVVTGGAGFIGSHLVDYLVYRLKADEVVVIDNLSSGSPRNIEMHIDAGVVRLVKADLSKRGEWEKGL
KGADIVFHYAANPEVRISSVEPGIHFENNVVATFNVLEAMRLGDVDKLVFASSSTVYGEPSVIPTPEDYHPLKPISIYGA
SKLASEVLIQVYSELYGFKALILRYANIIGARSNHGVIVDFINKLRTNPSRLEILGDGTQRKSYLHVSDAVEATMHLAVN
KLNSMHGVDVYNVGNHDWVTVTEIADIIVEEMGLGRVDYVFKKTTPDGRGWPGDVKLMLLDIRKLESTGWKPRLSSRDAV
RRTVRELLGKT

Sequences:

>Translated_331_residues
MSLYDAGEELSMRYVVTGGAGFIGSHLVDYLVYRLKADEVVVIDNLSSGSPRNIEMHIDAGVVRLVKADLSKRGEWEKGL
KGADIVFHYAANPEVRISSVEPGIHFENNVVATFNVLEAMRLGDVDKLVFASSSTVYGEPSVIPTPEDYHPLKPISIYGA
SKLASEVLIQVYSELYGFKALILRYANIIGARSNHGVIVDFINKLRTNPSRLEILGDGTQRKSYLHVSDAVEATMHLAVN
KLNSMHGVDVYNVGNHDWVTVTEIADIIVEEMGLGRVDYVFKKTTPDGRGWPGDVKLMLLDIRKLESTGWKPRLSSRDAV
RRTVRELLGKT
>Mature_330_residues
SLYDAGEELSMRYVVTGGAGFIGSHLVDYLVYRLKADEVVVIDNLSSGSPRNIEMHIDAGVVRLVKADLSKRGEWEKGLK
GADIVFHYAANPEVRISSVEPGIHFENNVVATFNVLEAMRLGDVDKLVFASSSTVYGEPSVIPTPEDYHPLKPISIYGAS
KLASEVLIQVYSELYGFKALILRYANIIGARSNHGVIVDFINKLRTNPSRLEILGDGTQRKSYLHVSDAVEATMHLAVNK
LNSMHGVDVYNVGNHDWVTVTEIADIIVEEMGLGRVDYVFKKTTPDGRGWPGDVKLMLLDIRKLESTGWKPRLSSRDAVR
RTVRELLGKT

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=28.2282282282282, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=29.2834890965732, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI56237023, Length=293, Percent_Identity=29.0102389078498, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI56118217, Length=293, Percent_Identity=29.0102389078498, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI189083684, Length=293, Percent_Identity=29.0102389078498, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI193211614, Length=266, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI8393516, Length=266, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786974, Length=266, Percent_Identity=30.8270676691729, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI48994969, Length=340, Percent_Identity=27.0588235294118, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788353, Length=354, Percent_Identity=26.271186440678, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788365, Length=246, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788589, Length=357, Percent_Identity=23.249299719888, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=328, Percent_Identity=30.4878048780488, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17568069, Length=263, Percent_Identity=28.8973384030418, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=28.7878787878788, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71982035, Length=333, Percent_Identity=28.2282282282282, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=335, Percent_Identity=28.0597014925373, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=348, Percent_Identity=31.6091954022989, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356223, Length=320, Percent_Identity=30.3125, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI19923002, Length=329, Percent_Identity=29.483282674772, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36671; Mature: 36540

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYDAGEELSMRYVVTGGAGFIGSHLVDYLVYRLKADEVVVIDNLSSGSPRNIEMHIDA
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECH
GVVRLVKADLSKRGEWEKGLKGADIVFHYAANPEVRISSVEPGIHFENNVVATFNVLEAM
HHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCEEEEECCCCCEECCCEEEHHHHHHHH
RLGDVDKLVFASSSTVYGEPSVIPTPEDYHPLKPISIYGASKLASEVLIQVYSELYGFKA
HHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LILRYANIIGARSNHGVIVDFINKLRTNPSRLEILGDGTQRKSYLHVSDAVEATMHLAVN
HHHHHHHHHCCCCCCCCHHEEHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHH
KLNSMHGVDVYNVGNHDWVTVTEIADIIVEEMGLGRVDYVFKKTTPDGRGWPGDVKLMLL
HHCCCCCCEEEECCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEE
DIRKLESTGWKPRLSSRDAVRRTVRELLGKT
EHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLYDAGEELSMRYVVTGGAGFIGSHLVDYLVYRLKADEVVVIDNLSSGSPRNIEMHIDA
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECH
GVVRLVKADLSKRGEWEKGLKGADIVFHYAANPEVRISSVEPGIHFENNVVATFNVLEAM
HHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCEEEEECCCCCEECCCEEEHHHHHHHH
RLGDVDKLVFASSSTVYGEPSVIPTPEDYHPLKPISIYGASKLASEVLIQVYSELYGFKA
HHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LILRYANIIGARSNHGVIVDFINKLRTNPSRLEILGDGTQRKSYLHVSDAVEATMHLAVN
HHHHHHHHHCCCCCCCCHHEEHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHH
KLNSMHGVDVYNVGNHDWVTVTEIADIIVEEMGLGRVDYVFKKTTPDGRGWPGDVKLMLL
HHCCCCCCEEEECCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEE
DIRKLESTGWKPRLSSRDAVRRTVRELLGKT
EHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]