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The map label for this gene is csd [H]

Identifier: 218883556

GI number: 218883556

Start: 227993

End: 229267

Strand: Reverse

Name: csd [H]

Synonym: DKAM_0245

Alternate gene names: 218883556

Gene position: 229267-227993 (Counterclockwise)

Preceding gene: 218883557

Following gene: 218883553

Centisome position: 16.79

GC content: 44.0

Gene sequence:

>1275_bases
GTGTCATGGATGTTTGACCCGGAGGAAATACGTAAGGATTTCCCCATCCTTAACAGAGAGGTCAACGGTAAGAAGTTGGT
CTACTTCGATAACGCCGCGACAACTCAGAAGCCTATCCAGGTGATCAACGCTATCAGAGACTTCTACATGTATCACAACG
CTAATGTACACCGTGGATTCCACACTCTGAGCCAAGAGGCTAGCCAGATGTATGAGGAAGCACATGAGAAGATAGCCAAG
TTCATTAACGCCTACTCGTGGAGAGAGATCATTTTCTGTAGTAATACTACCGAGGCATTGAACATAGTTGCCTATGGATG
GGGACTATGGAATCTCAGGGAGGGCGATGAGATAATATTAACAGTTATGGATCACCATAGCAGTATGCTTCCATGGAGAC
TGATAGCAAAGCTCAAGAATGCCAAGGTGAAATATATCGATATAACCAATGATGGATACTTAAAGTATGAACTGCTAGAG
GAATTTATCACCGAGAAAACACGCGTAGTAGCCTTCCCTATAGCAAGCAATGTCCTAGGCACGATAAATGATTCACGAAG
GATAGCTAGGTTGGCCCATAGTGTTGGAGCAATAGTTGTTGCCGACGGGGCTCAAAGCGTCCCCCATCTCCCGACAAATA
TAAAGGAGCTTGAAATAGACTTCCTCGCTTTTAGCGGGCATAAAATGCTCGGTCCCACCGGGATAGGTGTCCTATGGGGT
AGACAAGAGCTCCTCGAATCAATGCATCCATTTAAAGTCGGTGGAGATACAATCAAGGATGTCACATTGGATAATGTAGT
ATGGCATGACCTACCATGGAGGTTTGAAGCAGGTACACCTAATATAGCAGGGGGCATTGGATTAGGTGCTGCAGTAGACT
ACCTGTTGAAAATAGGTATGGAGAATGTGCGTGAACATGAGAAAGCATTAGTTGAATACACATTGAAGAGGCTTGGTGAG
ATTGAGGATGTGGAATATTATGGTCCACGCAATCCACGCGATAAGACTGGTGTAATAGCATTCAATATAAAGGGGTTAAA
CCACCACACAGTTGGCTCGGCACTCGACTTATTCGGTATAGCTGTGAGAACTGGAATGCATTGTGCACATCCATTACACT
ATAGGCTTGGATTAAAGGGTACTGTGAGGGCAAGCTACTATATATATAATACATTAGAAGAAGTGGACTACTTTATCGAG
ACCCTGGAGAAAATAGTTTCTCTAAAAGAGTCGCTTAAATCAAAACCACCTACAGAAGTCTGCACTGGTACATAG

Upstream 100 bases:

>100_bases
CTAGCTGGTTGAATCATTGTTTTTATAAGTGAAAGCCTCATCCTTTATAACGAGGGAGAATGTCAGCTATATTTAGGGCT
ATTGTTATGTCATTTAATAG

Downstream 100 bases:

>100_bases
CTAAAGAATTAGGATTACGAGGTAACGGTAATTAAAAAATAAATAATTTATTTTTATTCCTTAGAGTATTCATCAAGCCT
ACTTTGCTGGACCAAGGATT

Product: cysteine desulfurase, SufS subfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSWMFDPEEIRKDFPILNREVNGKKLVYFDNAATTQKPIQVINAIRDFYMYHNANVHRGFHTLSQEASQMYEEAHEKIAK
FINAYSWREIIFCSNTTEALNIVAYGWGLWNLREGDEIILTVMDHHSSMLPWRLIAKLKNAKVKYIDITNDGYLKYELLE
EFITEKTRVVAFPIASNVLGTINDSRRIARLAHSVGAIVVADGAQSVPHLPTNIKELEIDFLAFSGHKMLGPTGIGVLWG
RQELLESMHPFKVGGDTIKDVTLDNVVWHDLPWRFEAGTPNIAGGIGLGAAVDYLLKIGMENVREHEKALVEYTLKRLGE
IEDVEYYGPRNPRDKTGVIAFNIKGLNHHTVGSALDLFGIAVRTGMHCAHPLHYRLGLKGTVRASYYIYNTLEEVDYFIE
TLEKIVSLKESLKSKPPTEVCTGT

Sequences:

>Translated_424_residues
MSWMFDPEEIRKDFPILNREVNGKKLVYFDNAATTQKPIQVINAIRDFYMYHNANVHRGFHTLSQEASQMYEEAHEKIAK
FINAYSWREIIFCSNTTEALNIVAYGWGLWNLREGDEIILTVMDHHSSMLPWRLIAKLKNAKVKYIDITNDGYLKYELLE
EFITEKTRVVAFPIASNVLGTINDSRRIARLAHSVGAIVVADGAQSVPHLPTNIKELEIDFLAFSGHKMLGPTGIGVLWG
RQELLESMHPFKVGGDTIKDVTLDNVVWHDLPWRFEAGTPNIAGGIGLGAAVDYLLKIGMENVREHEKALVEYTLKRLGE
IEDVEYYGPRNPRDKTGVIAFNIKGLNHHTVGSALDLFGIAVRTGMHCAHPLHYRLGLKGTVRASYYIYNTLEEVDYFIE
TLEKIVSLKESLKSKPPTEVCTGT
>Mature_423_residues
SWMFDPEEIRKDFPILNREVNGKKLVYFDNAATTQKPIQVINAIRDFYMYHNANVHRGFHTLSQEASQMYEEAHEKIAKF
INAYSWREIIFCSNTTEALNIVAYGWGLWNLREGDEIILTVMDHHSSMLPWRLIAKLKNAKVKYIDITNDGYLKYELLEE
FITEKTRVVAFPIASNVLGTINDSRRIARLAHSVGAIVVADGAQSVPHLPTNIKELEIDFLAFSGHKMLGPTGIGVLWGR
QELLESMHPFKVGGDTIKDVTLDNVVWHDLPWRFEAGTPNIAGGIGLGAAVDYLLKIGMENVREHEKALVEYTLKRLGEI
EDVEYYGPRNPRDKTGVIAFNIKGLNHHTVGSALDLFGIAVRTGMHCAHPLHYRLGLKGTVRASYYIYNTLEEVDYFIET
LEKIVSLKESLKSKPPTEVCTGT

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=408, Percent_Identity=24.0196078431373, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=45.9057071960298, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=38.423645320197, Blast_Score=304, Evalue=9e-84,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=397, Percent_Identity=26.7002518891688, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=223, Percent_Identity=28.2511210762332, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6319831, Length=401, Percent_Identity=25.1870324189526, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20129463, Length=432, Percent_Identity=26.3888888888889, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 48006; Mature: 47874

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWMFDPEEIRKDFPILNREVNGKKLVYFDNAATTQKPIQVINAIRDFYMYHNANVHRGF
CCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
HTLSQEASQMYEEAHEKIAKFINAYSWREIIFCSNTTEALNIVAYGWGLWNLREGDEIIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHEEEEEEECCCCCCCCCCEEEE
TVMDHHSSMLPWRLIAKLKNAKVKYIDITNDGYLKYELLEEFITEKTRVVAFPIASNVLG
EEECCCCCCCHHHHHHHHHCCEEEEEEECCCCEEHHHHHHHHHCCCCEEEEEEHHCCHHC
TINDSRRIARLAHSVGAIVVADGAQSVPHLPTNIKELEIDFLAFSGHKMLGPTGIGVLWG
CCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHEEEEEEEECCCCEECCCCCEEEEC
RQELLESMHPFKVGGDTIKDVTLDNVVWHDLPWRFEAGTPNIAGGIGLGAAVDYLLKIGM
HHHHHHHCCCEECCCCCCCCEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHCH
ENVREHEKALVEYTLKRLGEIEDVEYYGPRNPRDKTGVIAFNIKGLNHHTVGSALDLFGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AVRTGMHCAHPLHYRLGLKGTVRASYYIYNTLEEVDYFIETLEKIVSLKESLKSKPPTEV
HHHCCCCCCCCCCEEECCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
CTGT
CCCC
>Mature Secondary Structure 
SWMFDPEEIRKDFPILNREVNGKKLVYFDNAATTQKPIQVINAIRDFYMYHNANVHRGF
CCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
HTLSQEASQMYEEAHEKIAKFINAYSWREIIFCSNTTEALNIVAYGWGLWNLREGDEIIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHEEEEEEECCCCCCCCCCEEEE
TVMDHHSSMLPWRLIAKLKNAKVKYIDITNDGYLKYELLEEFITEKTRVVAFPIASNVLG
EEECCCCCCCHHHHHHHHHCCEEEEEEECCCCEEHHHHHHHHHCCCCEEEEEEHHCCHHC
TINDSRRIARLAHSVGAIVVADGAQSVPHLPTNIKELEIDFLAFSGHKMLGPTGIGVLWG
CCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHEEEEEEEECCCCEECCCCCEEEEC
RQELLESMHPFKVGGDTIKDVTLDNVVWHDLPWRFEAGTPNIAGGIGLGAAVDYLLKIGM
HHHHHHHCCCEECCCCCCCCEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHCH
ENVREHEKALVEYTLKRLGEIEDVEYYGPRNPRDKTGVIAFNIKGLNHHTVGSALDLFGI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AVRTGMHCAHPLHYRLGLKGTVRASYYIYNTLEEVDYFIETLEKIVSLKESLKSKPPTEV
HHHCCCCCCCCCCEEECCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
CTGT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]