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The map label for this gene is dxr [H]

Identifier: 218710312

GI number: 218710312

Start: 2516244

End: 2517329

Strand: Reverse

Name: dxr [H]

Synonym: VS_2346

Alternate gene names: 218710312

Gene position: 2517329-2516244 (Counterclockwise)

Preceding gene: 218710313

Following gene: 218710311

Centisome position: 76.3

GC content: 45.4

Gene sequence:

>1086_bases
GTGCTGGCGTTAGTTGAAAAGTGGCAACCAAGCTATGTTGCTATGGCTTGCCCTGATGCAGCATCTAAGCTTACTGAAGT
GTTGTCTACGAATTGCCCAAACATCAAAGTTCTTTCTGGTTCTGAAGGCGTGTGTCAGGTCGCTTCTCTAGATGAAGTGG
ACACGGTAATGGCTGCTATTGTGGGTGCGGCAGGTTTGCTTCCTACGATGTCTGCGGTTAAGGCTGGTAAGCGCATCTTG
CTGGCTAACAAAGAAGCGTTGGTGATGTCTGGACAGTTGTTTATCGACGCCGTAGACAAGTACGGCGCTGAACTGCTTCC
TGTCGACAGTGAGCATAATGCTATCTTTCAATGCTTGCCTCAAAACGTACAAACTAACCTAGGCCGTTGTGATTTAGAAG
AGAACGGTATCAACCATATTCTTTTGACTGGTTCGGGTGGTCCTTTCCGTTATACGGACGTTGCAGAGCTAGAGTCGGTA
ACACCAGAACGAGCTATCGCACACCCAAACTGGTCAATGGGCCCTAAGATCTCTGTCGATTCAGCAACTATGATGAATAA
AGGCTTAGAGTACATTGAGGCGAAATGGCTATTTAATGCCTCTCAAGAGCAACTCAAAGTTATTATCCACCCTCAGTCTG
TGATTCATTCTATGGTTCAGTACAAGGATGGCTCGGTGCTCGCTCAAATGGGCGAACCCGATATGGCAACGCCAATCGCT
TTGACGATGTCTTATCCTGAACGTACAGAAGCGGGTGTTAAGCCTCTGGATTTCACCAAAGTGGGCGAGCTTACCTTCTT
AGAGCCCGATTTAACTCGTTACCCATGTTTGAGATTAGCCATTGAGGCGTGCTATTTGGGTCAGCATGCAACAACAGCGA
TTAATGCGGCAAACGAAATTGCAGTCGATGCTTTCTTGAACAATCAAGTGAAGTTTACCGATATTGCTATCATTAACGAG
TATGTTATGAACAAAGTATGTGAACAACATAACTCTGAGGGCTTAGATAGCTTGGAAAGCCTTCTTGAGCTAGATAATAT
GTCTCGTCAAATAGCCATTCAATTTATTAAAGAGCAGCTAGCATGA

Upstream 100 bases:

>100_bases
GCTCAATTGGTGCAAGTACACTAAAAGTCGTTGAACAAAACCCAGAACTCTATTCGGTCGTAGCAATGGCTGCAGGCTCG
AATGTTGAAAAGATGCTGGC

Downstream 100 bases:

>100_bases
GTGGAATTCTGTGGAACTTCGCATCTTTTATTGTAGCGCTTGGTATTCTGGTTGCTGTTCATGAGTTTGGACACTTCTGG
GTTGCTCGTCGTTGTGGTGT

Product: putative 1-deoxy-D-xylulose 5-phosphate reductoisomeras

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLALVEKWQPSYVAMACPDAASKLTEVLSTNCPNIKVLSGSEGVCQVASLDEVDTVMAAIVGAAGLLPTMSAVKAGKRIL
LANKEALVMSGQLFIDAVDKYGAELLPVDSEHNAIFQCLPQNVQTNLGRCDLEENGINHILLTGSGGPFRYTDVAELESV
TPERAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFNASQEQLKVIIHPQSVIHSMVQYKDGSVLAQMGEPDMATPIA
LTMSYPERTEAGVKPLDFTKVGELTFLEPDLTRYPCLRLAIEACYLGQHATTAINAANEIAVDAFLNNQVKFTDIAIINE
YVMNKVCEQHNSEGLDSLESLLELDNMSRQIAIQFIKEQLA

Sequences:

>Translated_361_residues
MLALVEKWQPSYVAMACPDAASKLTEVLSTNCPNIKVLSGSEGVCQVASLDEVDTVMAAIVGAAGLLPTMSAVKAGKRIL
LANKEALVMSGQLFIDAVDKYGAELLPVDSEHNAIFQCLPQNVQTNLGRCDLEENGINHILLTGSGGPFRYTDVAELESV
TPERAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFNASQEQLKVIIHPQSVIHSMVQYKDGSVLAQMGEPDMATPIA
LTMSYPERTEAGVKPLDFTKVGELTFLEPDLTRYPCLRLAIEACYLGQHATTAINAANEIAVDAFLNNQVKFTDIAIINE
YVMNKVCEQHNSEGLDSLESLLELDNMSRQIAIQFIKEQLA
>Mature_361_residues
MLALVEKWQPSYVAMACPDAASKLTEVLSTNCPNIKVLSGSEGVCQVASLDEVDTVMAAIVGAAGLLPTMSAVKAGKRIL
LANKEALVMSGQLFIDAVDKYGAELLPVDSEHNAIFQCLPQNVQTNLGRCDLEENGINHILLTGSGGPFRYTDVAELESV
TPERAIAHPNWSMGPKISVDSATMMNKGLEYIEAKWLFNASQEQLKVIIHPQSVIHSMVQYKDGSVLAQMGEPDMATPIA
LTMSYPERTEAGVKPLDFTKVGELTFLEPDLTRYPCLRLAIEACYLGQHATTAINAANEIAVDAFLNNQVKFTDIAIINE
YVMNKVCEQHNSEGLDSLESLLELDNMSRQIAIQFIKEQLA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=346, Percent_Identity=59.8265895953757, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 39347; Mature: 39347

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALVEKWQPSYVAMACPDAASKLTEVLSTNCPNIKVLSGSEGVCQVASLDEVDTVMAAI
CCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHHHHH
VGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVDKYGAELLPVDSEHNAIFQCLP
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECHHHEEEHHHCCCEEEECCCCCCHHHHHCC
QNVQTNLGRCDLEENGINHILLTGSGGPFRYTDVAELESVTPERAIAHPNWSMGPKISVD
HHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHCCCHHHCCCCCCCCCCEEECC
SATMMNKGLEYIEAKWLFNASQEQLKVIIHPQSVIHSMVQYKDGSVLAQMGEPDMATPIA
HHHHHHHCHHHHHHHHHCCCCCHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEE
LTMSYPERTEAGVKPLDFTKVGELTFLEPDLTRYPCLRLAIEACYLGQHATTAINAANEI
EEECCCCHHHCCCCCCCCEECCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHH
AVDAFLNNQVKFTDIAIINEYVMNKVCEQHNSEGLDSLESLLELDNMSRQIAIQFIKEQL
EEEHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MLALVEKWQPSYVAMACPDAASKLTEVLSTNCPNIKVLSGSEGVCQVASLDEVDTVMAAI
CCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHHHHH
VGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVDKYGAELLPVDSEHNAIFQCLP
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECHHHEEEHHHCCCEEEECCCCCCHHHHHCC
QNVQTNLGRCDLEENGINHILLTGSGGPFRYTDVAELESVTPERAIAHPNWSMGPKISVD
HHHHCCCCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHCCCHHHCCCCCCCCCCEEECC
SATMMNKGLEYIEAKWLFNASQEQLKVIIHPQSVIHSMVQYKDGSVLAQMGEPDMATPIA
HHHHHHHCHHHHHHHHHCCCCCHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEE
LTMSYPERTEAGVKPLDFTKVGELTFLEPDLTRYPCLRLAIEACYLGQHATTAINAANEI
EEECCCCHHHCCCCCCCCEECCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHH
AVDAFLNNQVKFTDIAIINEYVMNKVCEQHNSEGLDSLESLLELDNMSRQIAIQFIKEQL
EEEHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA