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The map label for this gene is cysG [H]

Identifier: 218709395

GI number: 218709395

Start: 1534995

End: 1535936

Strand: Direct

Name: cysG [H]

Synonym: VS_1404

Alternate gene names: 218709395

Gene position: 1534995-1535936 (Clockwise)

Preceding gene: 218709388

Following gene: 218709398

Centisome position: 46.52

GC content: 42.36

Gene sequence:

>942_bases
ATGCGTTATTTCCCAATGTTTTTGGATGTAGAGAATAAGCCAATTCTAGTGGTTGGTGGGGGCGAGGTTGCTTGCCGAAA
AGTCGACAGTTTGCTGCGAGCGGGTGCTAATGTAACTTTGGTTTCTCCTAAGGTCGCACCTTACTTAAAAGAGCTAGCCG
ATGAAGACAAACTTCGTTGGGTTCAAAATTTTTACTCGTCACAGCTTATCTCGAAAAACTACTTACAAGTGTGGGCAACC
ACAGACAACCCAAACCTAAATCATCAAGTACATAATGATGCAAAAAAAATGGGTATTCTTGTCAATGTGGTCGATGACTT
ACCCTATTGTGATTTCATCACACCCTCAATGATAAATCGCGGACGAATCCAAATAGCGATCTCAAGTGGGGGTGCATCAC
CTGTTTTGGTGAGAAATATTAGAGAAAAACTCGAAACTGTATTGCCACAGAACATAGGTTTGATAGCGGACTTCGGTGCA
TCAAAACGCAATTCAATTAAAGAGTCCTTTCCTACTGTTGATGAACGCCGAAAATTCTGGGAGCGCTTTTTGTCGTCCAG
TTTTATTAATCAAGTGACGGATAGGGATCAACTTGAATCGTACTATCAACAGTCGTTGACTGAGCAAGTTGATAGTGAAG
GGCAGGTCACTTGGATCGAATTTGAAGAAGATGTTGAGCTACTTTCTATGAAGGCTTTACGTCTGATGCAAGAGGCAGAG
CTAGTACTTTCACCAATCGATTGTCCATTCGAATTTATAGACTTATGCCGTCGAGATGCAGAAAGAGATAGCTATGTTAA
TAGCGGAGAGCTATCGACCAAGCTTGAGCAAGCCAGAGCTGAGAAATTACGAGTGTGTGTGTTTATTCCACCAGCAAGCG
TAGAGTTTAATCTATTGGTTGGCAAAGACCTGAAACTGTCTGCTGCAAAAGTGCTCAGGTGA

Upstream 100 bases:

>100_bases
TTTGGTCAATAAATATTTTTATTACGCTTGGATAGTTATGAATATGCTCCAAATTTGGTAGCATGTCTGAATAGTTATTG
AAGTAGTCTCAAGGAAGAAC

Downstream 100 bases:

>100_bases
GTGGTAGTTGATAGATTTTAGTTGAAGTGAGCGCTTTTTAGTTGTTTGCAAATCGGCTAGAGACCCTGAATAAGACTGAC
CGATAAATAAAAAGCCACTT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MRYFPMFLDVENKPILVVGGGEVACRKVDSLLRAGANVTLVSPKVAPYLKELADEDKLRWVQNFYSSQLISKNYLQVWAT
TDNPNLNHQVHNDAKKMGILVNVVDDLPYCDFITPSMINRGRIQIAISSGGASPVLVRNIREKLETVLPQNIGLIADFGA
SKRNSIKESFPTVDERRKFWERFLSSSFINQVTDRDQLESYYQQSLTEQVDSEGQVTWIEFEEDVELLSMKALRLMQEAE
LVLSPIDCPFEFIDLCRRDAERDSYVNSGELSTKLEQARAEKLRVCVFIPPASVEFNLLVGKDLKLSAAKVLR

Sequences:

>Translated_313_residues
MRYFPMFLDVENKPILVVGGGEVACRKVDSLLRAGANVTLVSPKVAPYLKELADEDKLRWVQNFYSSQLISKNYLQVWAT
TDNPNLNHQVHNDAKKMGILVNVVDDLPYCDFITPSMINRGRIQIAISSGGASPVLVRNIREKLETVLPQNIGLIADFGA
SKRNSIKESFPTVDERRKFWERFLSSSFINQVTDRDQLESYYQQSLTEQVDSEGQVTWIEFEEDVELLSMKALRLMQEAE
LVLSPIDCPFEFIDLCRRDAERDSYVNSGELSTKLEQARAEKLRVCVFIPPASVEFNLLVGKDLKLSAAKVLR
>Mature_313_residues
MRYFPMFLDVENKPILVVGGGEVACRKVDSLLRAGANVTLVSPKVAPYLKELADEDKLRWVQNFYSSQLISKNYLQVWAT
TDNPNLNHQVHNDAKKMGILVNVVDDLPYCDFITPSMINRGRIQIAISSGGASPVLVRNIREKLETVLPQNIGLIADFGA
SKRNSIKESFPTVDERRKFWERFLSSSFINQVTDRDQLESYYQQSLTEQVDSEGQVTWIEFEEDVELLSMKALRLMQEAE
LVLSPIDCPFEFIDLCRRDAERDSYVNSGELSTKLEQARAEKLRVCVFIPPASVEFNLLVGKDLKLSAAKVLR

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=266, Percent_Identity=35.3383458646617, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 35556; Mature: 35556

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFPMFLDVENKPILVVGGGEVACRKVDSLLRAGANVTLVSPKVAPYLKELADEDKLRW
CCEECEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCHHHHHH
VQNFYSSQLISKNYLQVWATTDNPNLNHQVHNDAKKMGILVNVVDDLPYCDFITPSMINR
HHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHEEHHHCCCCCCCCCHHHCCC
GRIQIAISSGGASPVLVRNIREKLETVLPQNIGLIADFGASKRNSIKESFPTVDERRKFW
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHH
ERFLSSSFINQVTDRDQLESYYQQSLTEQVDSEGQVTWIEFEEDVELLSMKALRLMQEAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
LVLSPIDCPFEFIDLCRRDAERDSYVNSGELSTKLEQARAEKLRVCVFIPPASVEFNLLV
HHCCCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEEEE
GKDLKLSAAKVLR
CCCCCHHHHHHCC
>Mature Secondary Structure
MRYFPMFLDVENKPILVVGGGEVACRKVDSLLRAGANVTLVSPKVAPYLKELADEDKLRW
CCEECEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCHHHHHH
VQNFYSSQLISKNYLQVWATTDNPNLNHQVHNDAKKMGILVNVVDDLPYCDFITPSMINR
HHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHEEHHHCCCCCCCCCHHHCCC
GRIQIAISSGGASPVLVRNIREKLETVLPQNIGLIADFGASKRNSIKESFPTVDERRKFW
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHH
ERFLSSSFINQVTDRDQLESYYQQSLTEQVDSEGQVTWIEFEEDVELLSMKALRLMQEAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
LVLSPIDCPFEFIDLCRRDAERDSYVNSGELSTKLEQARAEKLRVCVFIPPASVEFNLLV
HHCCCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEEEE
GKDLKLSAAKVLR
CCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA