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The map label for this gene is tnaA [H]

Identifier: 218709255

GI number: 218709255

Start: 1360325

End: 1361797

Strand: Direct

Name: tnaA [H]

Synonym: VS_1262

Alternate gene names: 218709255

Gene position: 1360325-1361797 (Clockwise)

Preceding gene: 218709254

Following gene: 218709257

Centisome position: 41.23

GC content: 47.79

Gene sequence:

>1473_bases
ATGGAAAACTTCAAACATCTACCAGAACCGTTTCGTATTCGTGTTGTAGAGCCAGTAAAAAGAACAACTCGTGCCTATCG
TGAACAAGCCATTGTCGATGCGGGGATGAACCCATTCTTACTTGATAGTGATGATGTGTTTATCGACTTACTGACAGACA
GCGGAACAGGATCTATTACTCAGCGCATGCAAGCCGCGATGTTAATGGGGGATGAAGCTTACAGTGGTAGTCGCAGTTAC
TATGCATTGTCGAATGCGGTGAAAGATATCTTCGGTTACGAGTTGACGATTCCAACGCACCAAGGGCGCGGCGCAGAGCA
GATCTACATTCCTGTTCTTATCAAGAAGCGTGAAATGGAGAAAGGTCTCGATCGCAGCAAAATGGTTGCTCTGTCGAACT
ACTTCTTCGATACAACACAAGGTCACACCCAAGTGAATTGCTGTGTGGCGAAGAACGTTTATACCAAAGAAGCGTTCGAT
ACTTCGGTGAACGCGGATTTCAAAGGCAACTTCGATGTGGTGAAGCTGGAAGAAGCTATTTTAGAAGCGGGGGCTGCTAA
TGTTCCTTACATTGTGAGTACCATTACTTGTAACTCTGCTGGTGGGCAGCCAGTGTCTATTGCCAATCTAAAAGCCGTGT
ATCAAGTGGCTCAGAAGTACGACATCCCTGTGATCATGGACTCTGCACGCTACGCTGAAAATGCCTACTTCATTCAACAA
CGAGAAGCGGGTTATCAAGATTGGACAATCGAACAGATCACGCGTGAGTCTTACAAATACGCGGATGGCTTAGCCATGTC
TGCTAAGAAAGATGCCATGGTACAAATGGGCGGCTTACTCTGCTTTAAAGACGACTCTTTCATGGATGTGTACACAGAGT
GTCGAACCTTGTGTGTCGTGCAAGAAGGCTTCCCAACCTATGGTGGCTTAGAAGGTGGCGCGATGGAGCGTTTGGCGGTT
GGCCTTTATGACGGCATGCGCCAAGATTGGTTAGAGTACCGTATTGGTCAGGTTCATTACTTAGTTGATGGCTTAGAAGC
GATGGGCATCGTGTGCCAGCAAGCAGGCGGTCATGCTGCGTTTGTGGATGCGGGTAAACTGCTTCCTCATATTCCAGCAG
GTCAGTTCCCAGCACATGCTTTGGCGTGTGAACTCTATAAAGTCGCGGGTATCAGAGCGGTTGAGATTGGCTCATTGCTG
CAAGGTCGCGACCCAGCAACCGGTGAACAACACCCATGCCCTGCAGAGTTATTGCGCCTTACCATTCCTCGCGCGACCTA
CACACAAACTCACATGGACTTCATCATCGAAGCATTTGAAAAAGTGAAAGAGAATGCAGGACAAGTGAAAGGGCTCGACT
TTACCTACGAGCCGCCGGTGTTAAGACATTTCACTGCGCGCTTGAAAGAGGTAGAGACCAGCGAGAAACAAACAGAAAAA
AAGAATGAACAAACGCTCGAAGAAGCATTTTAA

Upstream 100 bases:

>100_bases
TGTGTGTATTTATACGGAACTAATAATTTAATGGTGAGGATTCGTGACATCTAAAGAAAATAGATTTCGACCTGATCGGA
ATGTATTGAAAGGTATTATT

Downstream 100 bases:

>100_bases
AATAAAAACATAAGCGAATAGTCACTAGAAACATAATCAAAGGCTCCCTCGGGAGCCTTTTCTTTTTTTGGATGGTAGGG
GAGTTATGTCGTTAAGCAGC

Product: tryptophanase

Products: NA

Alternate protein names: L-tryptophan indole-lyase; TNase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MENFKHLPEPFRIRVVEPVKRTTRAYREQAIVDAGMNPFLLDSDDVFIDLLTDSGTGSITQRMQAAMLMGDEAYSGSRSY
YALSNAVKDIFGYELTIPTHQGRGAEQIYIPVLIKKREMEKGLDRSKMVALSNYFFDTTQGHTQVNCCVAKNVYTKEAFD
TSVNADFKGNFDVVKLEEAILEAGAANVPYIVSTITCNSAGGQPVSIANLKAVYQVAQKYDIPVIMDSARYAENAYFIQQ
REAGYQDWTIEQITRESYKYADGLAMSAKKDAMVQMGGLLCFKDDSFMDVYTECRTLCVVQEGFPTYGGLEGGAMERLAV
GLYDGMRQDWLEYRIGQVHYLVDGLEAMGIVCQQAGGHAAFVDAGKLLPHIPAGQFPAHALACELYKVAGIRAVEIGSLL
QGRDPATGEQHPCPAELLRLTIPRATYTQTHMDFIIEAFEKVKENAGQVKGLDFTYEPPVLRHFTARLKEVETSEKQTEK
KNEQTLEEAF

Sequences:

>Translated_490_residues
MENFKHLPEPFRIRVVEPVKRTTRAYREQAIVDAGMNPFLLDSDDVFIDLLTDSGTGSITQRMQAAMLMGDEAYSGSRSY
YALSNAVKDIFGYELTIPTHQGRGAEQIYIPVLIKKREMEKGLDRSKMVALSNYFFDTTQGHTQVNCCVAKNVYTKEAFD
TSVNADFKGNFDVVKLEEAILEAGAANVPYIVSTITCNSAGGQPVSIANLKAVYQVAQKYDIPVIMDSARYAENAYFIQQ
REAGYQDWTIEQITRESYKYADGLAMSAKKDAMVQMGGLLCFKDDSFMDVYTECRTLCVVQEGFPTYGGLEGGAMERLAV
GLYDGMRQDWLEYRIGQVHYLVDGLEAMGIVCQQAGGHAAFVDAGKLLPHIPAGQFPAHALACELYKVAGIRAVEIGSLL
QGRDPATGEQHPCPAELLRLTIPRATYTQTHMDFIIEAFEKVKENAGQVKGLDFTYEPPVLRHFTARLKEVETSEKQTEK
KNEQTLEEAF
>Mature_490_residues
MENFKHLPEPFRIRVVEPVKRTTRAYREQAIVDAGMNPFLLDSDDVFIDLLTDSGTGSITQRMQAAMLMGDEAYSGSRSY
YALSNAVKDIFGYELTIPTHQGRGAEQIYIPVLIKKREMEKGLDRSKMVALSNYFFDTTQGHTQVNCCVAKNVYTKEAFD
TSVNADFKGNFDVVKLEEAILEAGAANVPYIVSTITCNSAGGQPVSIANLKAVYQVAQKYDIPVIMDSARYAENAYFIQQ
REAGYQDWTIEQITRESYKYADGLAMSAKKDAMVQMGGLLCFKDDSFMDVYTECRTLCVVQEGFPTYGGLEGGAMERLAV
GLYDGMRQDWLEYRIGQVHYLVDGLEAMGIVCQQAGGHAAFVDAGKLLPHIPAGQFPAHALACELYKVAGIRAVEIGSLL
QGRDPATGEQHPCPAELLRLTIPRATYTQTHMDFIIEAFEKVKENAGQVKGLDFTYEPPVLRHFTARLKEVETSEKQTEK
KNEQTLEEAF

Specific function: Tryptophan catabolism. [C]

COG id: COG3033

COG function: function code E; Tryptophanase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-eliminating lyase family [H]

Homologues:

Organism=Escherichia coli, GI87082323, Length=471, Percent_Identity=83.4394904458599, Blast_Score=836, Evalue=0.0,

Paralogues:

None

Copy number: 7160 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 460 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011166
- InterPro:   IPR013440
- InterPro:   IPR018176 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.99.1 [H]

Molecular weight: Translated: 54589; Mature: 54589

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00853 BETA_ELIM_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFKHLPEPFRIRVVEPVKRTTRAYREQAIVDAGMNPFLLDSDDVFIDLLTDSGTGSIT
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCHHH
QRMQAAMLMGDEAYSGSRSYYALSNAVKDIFGYELTIPTHQGRGAEQIYIPVLIKKREME
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEEEHHHHH
KGLDRSKMVALSNYFFDTTQGHTQVNCCVAKNVYTKEAFDTSVNADFKGNFDVVKLEEAI
CCCCHHHHHHHHHHEEECCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCEEHHHHHH
LEAGAANVPYIVSTITCNSAGGQPVSIANLKAVYQVAQKYDIPVIMDSARYAENAYFIQQ
HHCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCEEECCCHHCCCEEEEEH
REAGYQDWTIEQITRESYKYADGLAMSAKKDAMVQMGGLLCFKDDSFMDVYTECRTLCVV
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHHEEEE
QEGFPTYGGLEGGAMERLAVGLYDGMRQDWLEYRIGQVHYLVDGLEAMGIVCQQAGGHAA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEE
FVDAGKLLPHIPAGQFPAHALACELYKVAGIRAVEIGSLLQGRDPATGEQHPCPAELLRL
EEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCCCCCHHHHHHE
TIPRATYTQTHMDFIIEAFEKVKENAGQVKGLDFTYEPPVLRHFTARLKEVETSEKQTEK
ECCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KNEQTLEEAF
HHHHHHHHCC
>Mature Secondary Structure
MENFKHLPEPFRIRVVEPVKRTTRAYREQAIVDAGMNPFLLDSDDVFIDLLTDSGTGSIT
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCCCCHHH
QRMQAAMLMGDEAYSGSRSYYALSNAVKDIFGYELTIPTHQGRGAEQIYIPVLIKKREME
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEEEHHHHH
KGLDRSKMVALSNYFFDTTQGHTQVNCCVAKNVYTKEAFDTSVNADFKGNFDVVKLEEAI
CCCCHHHHHHHHHHEEECCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCEEHHHHHH
LEAGAANVPYIVSTITCNSAGGQPVSIANLKAVYQVAQKYDIPVIMDSARYAENAYFIQQ
HHCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCEEECCCHHCCCEEEEEH
REAGYQDWTIEQITRESYKYADGLAMSAKKDAMVQMGGLLCFKDDSFMDVYTECRTLCVV
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHHEEEE
QEGFPTYGGLEGGAMERLAVGLYDGMRQDWLEYRIGQVHYLVDGLEAMGIVCQQAGGHAA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEE
FVDAGKLLPHIPAGQFPAHALACELYKVAGIRAVEIGSLLQGRDPATGEQHPCPAELLRL
EEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCCCCCHHHHHHE
TIPRATYTQTHMDFIIEAFEKVKENAGQVKGLDFTYEPPVLRHFTARLKEVETSEKQTEK
ECCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KNEQTLEEAF
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA