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The map label for this gene is hisC1 [H]

Identifier: 218709145

GI number: 218709145

Start: 1219515

End: 1220648

Strand: Direct

Name: hisC1 [H]

Synonym: VS_1152

Alternate gene names: 218709145

Gene position: 1219515-1220648 (Clockwise)

Preceding gene: 218709138

Following gene: 218709146

Centisome position: 36.96

GC content: 43.92

Gene sequence:

>1134_bases
TTGACATCTTTTATTGATAGCTTAGTGCCTCAGGCTGTAAAAAAATTAATACCTTATCAATCGGCAAGAAGAATTGGTGG
TGATGGACGTGTCTGGCTAAACGCTAATGAATTGGAAAGCCCGCTGTTTCAAGGAGAAGCAAGTCACAACCGATACCCGG
ACTTCTTACCACAAGATATTGCTAAGGCTTACCAAGATTACTGTGGCACTGATGCCGCGACGGTTGCTGTCCGTGGTGCA
GATGAAGCGATTGATTTGCTGATCAGAACATTCTGTAAACCGGCGAGCGATAACATACTTATCTGTTCTCCAACGTATGC
GATGTATGAGTTTTGCGCCGATGCATTGGCGATTAATACCTTAGACTCTCCATTGCAGGAAGACTTCAGCCTTAATGTTG
CTGATATCGTGAATAAAGCGGAATTGGCTAATATCGTGTTTCTTTGCTCACCAAACAACCCTACGGGCAATGTGATCCCT
AAATTGGATTTGATTCAGGTACTGGAAGGCACGATTGGCAAGTCGCTAGTGGTAGTCGATGAAGCGTATATCGAATTTGA
ACCACAAACGTCAGCGGTGAGCCTTATTGCGCGTTATCCGCATTTGGTTGTGATTCGCACCTTGTCTAAGGCGTTTGGGT
TGGCTGCGGTTCGTTGTGGCTTTATCTTAGCGAGTCAAAATGTGATGCAGTATGTCGCGAAGTTGATTCCACCTTATCCG
ATGCCAGATTGCTCATCTCAAATTGTACTAGACGCATTGTCTGATGAACGAATTGCGTTGATGGAAAGCGCGACGTTAAA
GTTGGTCGAATTGCGTAATCGGTTTGCTTGTGAGCTAACGCGGTTTGAATTTATAGAACAGGTTTATCCGTCATCGACCA
ATTTCGTTTTGCTACGTCAAAAACCGGGGCACCATGTGTTTAGCGTATTGGCGAAGGATGGCATTGTTACAAGAAACCAA
AACCACGAACCTGCTTTGCGTAACTGTGTACGAATCAGTATTGGTAGCCAAGAGAGCATGCTAGAAGTGATAACGTCACT
AACACGCTACCAAACCGAATTAGAAAAGAATCAACAAGGCAAACAATCTCAGCATAAAGAAACTCAATCTCAACTCGATA
AAGATCATATCTAG

Upstream 100 bases:

>100_bases
TACTTAATCATCATTTGTGATTCAATATGTGTATAAGTCACATTTTTTGAATATGAAGGCAATGATGAAGACATTGTGAT
TTTTTGAAAGGGATAGCTTC

Downstream 100 bases:

>100_bases
GATGGCAATGATGAAAAAGATAATACTAGGACTCGCTTGTGCGGCCGCTTTACTTGGTACAACGGTACAGGCGAAAGAAA
TCCGTTTGGCGTCAGACTTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTSFIDSLVPQAVKKLIPYQSARRIGGDGRVWLNANELESPLFQGEASHNRYPDFLPQDIAKAYQDYCGTDAATVAVRGA
DEAIDLLIRTFCKPASDNILICSPTYAMYEFCADALAINTLDSPLQEDFSLNVADIVNKAELANIVFLCSPNNPTGNVIP
KLDLIQVLEGTIGKSLVVVDEAYIEFEPQTSAVSLIARYPHLVVIRTLSKAFGLAAVRCGFILASQNVMQYVAKLIPPYP
MPDCSSQIVLDALSDERIALMESATLKLVELRNRFACELTRFEFIEQVYPSSTNFVLLRQKPGHHVFSVLAKDGIVTRNQ
NHEPALRNCVRISIGSQESMLEVITSLTRYQTELEKNQQGKQSQHKETQSQLDKDHI

Sequences:

>Translated_377_residues
MTSFIDSLVPQAVKKLIPYQSARRIGGDGRVWLNANELESPLFQGEASHNRYPDFLPQDIAKAYQDYCGTDAATVAVRGA
DEAIDLLIRTFCKPASDNILICSPTYAMYEFCADALAINTLDSPLQEDFSLNVADIVNKAELANIVFLCSPNNPTGNVIP
KLDLIQVLEGTIGKSLVVVDEAYIEFEPQTSAVSLIARYPHLVVIRTLSKAFGLAAVRCGFILASQNVMQYVAKLIPPYP
MPDCSSQIVLDALSDERIALMESATLKLVELRNRFACELTRFEFIEQVYPSSTNFVLLRQKPGHHVFSVLAKDGIVTRNQ
NHEPALRNCVRISIGSQESMLEVITSLTRYQTELEKNQQGKQSQHKETQSQLDKDHI
>Mature_376_residues
TSFIDSLVPQAVKKLIPYQSARRIGGDGRVWLNANELESPLFQGEASHNRYPDFLPQDIAKAYQDYCGTDAATVAVRGAD
EAIDLLIRTFCKPASDNILICSPTYAMYEFCADALAINTLDSPLQEDFSLNVADIVNKAELANIVFLCSPNNPTGNVIPK
LDLIQVLEGTIGKSLVVVDEAYIEFEPQTSAVSLIARYPHLVVIRTLSKAFGLAAVRCGFILASQNVMQYVAKLIPPYPM
PDCSSQIVLDALSDERIALMESATLKLVELRNRFACELTRFEFIEQVYPSSTNFVLLRQKPGHHVFSVLAKDGIVTRNQN
HEPALRNCVRISIGSQESMLEVITSLTRYQTELEKNQQGKQSQHKETQSQLDKDHI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=42.9799426934097, Blast_Score=293, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6322075, Length=371, Percent_Identity=30.188679245283, Blast_Score=159, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41926; Mature: 41795

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFIDSLVPQAVKKLIPYQSARRIGGDGRVWLNANELESPLFQGEASHNRYPDFLPQDI
CCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECHHHHCHHHCCCCCCCCCCCCCHHHH
AKAYQDYCGTDAATVAVRGADEAIDLLIRTFCKPASDNILICSPTYAMYEFCADALAINT
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHH
LDSPLQEDFSLNVADIVNKAELANIVFLCSPNNPTGNVIPKLDLIQVLEGTIGKSLVVVD
CCCHHHHHCCCCHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
EAYIEFEPQTSAVSLIARYPHLVVIRTLSKAFGLAAVRCGFILASQNVMQYVAKLIPPYP
EEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MPDCSSQIVLDALSDERIALMESATLKLVELRNRFACELTRFEFIEQVYPSSTNFVLLRQ
CCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
KPGHHVFSVLAKDGIVTRNQNHEPALRNCVRISIGSQESMLEVITSLTRYQTELEKNQQG
CCCHHHHHHHHHCCCEECCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
KQSQHKETQSQLDKDHI
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSFIDSLVPQAVKKLIPYQSARRIGGDGRVWLNANELESPLFQGEASHNRYPDFLPQDI
CHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECHHHHCHHHCCCCCCCCCCCCCHHHH
AKAYQDYCGTDAATVAVRGADEAIDLLIRTFCKPASDNILICSPTYAMYEFCADALAINT
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHH
LDSPLQEDFSLNVADIVNKAELANIVFLCSPNNPTGNVIPKLDLIQVLEGTIGKSLVVVD
CCCHHHHHCCCCHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
EAYIEFEPQTSAVSLIARYPHLVVIRTLSKAFGLAAVRCGFILASQNVMQYVAKLIPPYP
EEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MPDCSSQIVLDALSDERIALMESATLKLVELRNRFACELTRFEFIEQVYPSSTNFVLLRQ
CCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
KPGHHVFSVLAKDGIVTRNQNHEPALRNCVRISIGSQESMLEVITSLTRYQTELEKNQQG
CCCHHHHHHHHHCCCEECCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
KQSQHKETQSQLDKDHI
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]