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The map label for this gene is hemK [H]

Identifier: 218708756

GI number: 218708756

Start: 774218

End: 775090

Strand: Direct

Name: hemK [H]

Synonym: VS_0753

Alternate gene names: 218708756

Gene position: 774218-775090 (Clockwise)

Preceding gene: 218708755

Following gene: 218708757

Centisome position: 23.47

GC content: 45.13

Gene sequence:

>873_bases
ATGCAGTCAGCATATACGGTTGAAAGTGCTTTAAAGTCAGCAATCGTACAGCTTCAAGAGGGCGATAACACATCGCCCTC
GATTGATGCTACGGTACTGCTTTGCCACGCCTTAGATAAACCTAGATCTTACCTACTGACTTGGCCTGAGAAGCATCTCA
CTTCAGAACAAGAATCCGAATTCAATACCCTTCTAAAACGTCGCTTAACCGGTGAGCCTGTGGCTTATATTGTTGGTGAA
CGTGAGTTTTGGTCGCTGCCGTTAAAAGTTTCTCCTTCTACTTTAATCCCACGTCCAGATACGGAACGCTTGGTTGAAGT
GGCGTTAGACAAAACGTATGGCAAGCAAGGTGCGATTCTCGATTTAGGAACTGGTACTGGTGCGATCGCTTTGGCATTGG
CGTCTGAGATGCCGAACCGACCAGTGACGGGTATTGATCTTCGTCCGGAAGCGCAGCAACTTGCGACAGAAAACGCTCAG
CGATTAAATATCACTAACGCCACTTTTTTACATGGCAGTTGGTTTGAACCTTTGAACTCGGTGAATTCTGAAGAAAAAGC
TGTGAAGTTCTCGTTGATTGTCTCTAACCCACCTTACATTGAGAAGAATGACCCTCATTTATCTCAAGGTGATGTGCGTT
TTGAACCGATCACAGCGTTAGTTGCTGAAGAGAAAGGTTTAGCTGATATTCGATACATCTCTGAAAATGCACGAAGCTTT
TTAGAAAACGAAGGTTGGTTAGCGTTTGAACACGGTTACGACCAAGGTTTAGCTGTACGTGAGATTATGCAGGCGCTCGG
ATATCTCGATGTTGTGACAGAGAAAGATTACGGTGGTAATGACCGAGTGACATTGGGTCGTTACTGTTCATAG

Upstream 100 bases:

>100_bases
ACGAAGTTCTGGAAGGTGATATGCAAAGCCTGCTTGATCCTGTTCTACAAGAGCACCAAGCCGATCAACTAGCAGCACTT
GCTGAGCACAACTAATTACT

Downstream 100 bases:

>100_bases
GCTGCTGTTAATCATCTTGTGAGCAATAGATGATGAACTTGCTAAATTGATACCTTTAACTCGAAAATACACTTAACTTG
ATAATGCATTTAACGCAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MQSAYTVESALKSAIVQLQEGDNTSPSIDATVLLCHALDKPRSYLLTWPEKHLTSEQESEFNTLLKRRLTGEPVAYIVGE
REFWSLPLKVSPSTLIPRPDTERLVEVALDKTYGKQGAILDLGTGTGAIALALASEMPNRPVTGIDLRPEAQQLATENAQ
RLNITNATFLHGSWFEPLNSVNSEEKAVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARSF
LENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRYCS

Sequences:

>Translated_290_residues
MQSAYTVESALKSAIVQLQEGDNTSPSIDATVLLCHALDKPRSYLLTWPEKHLTSEQESEFNTLLKRRLTGEPVAYIVGE
REFWSLPLKVSPSTLIPRPDTERLVEVALDKTYGKQGAILDLGTGTGAIALALASEMPNRPVTGIDLRPEAQQLATENAQ
RLNITNATFLHGSWFEPLNSVNSEEKAVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARSF
LENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRYCS
>Mature_290_residues
MQSAYTVESALKSAIVQLQEGDNTSPSIDATVLLCHALDKPRSYLLTWPEKHLTSEQESEFNTLLKRRLTGEPVAYIVGE
REFWSLPLKVSPSTLIPRPDTERLVEVALDKTYGKQGAILDLGTGTGAIALALASEMPNRPVTGIDLRPEAQQLATENAQ
RLNITNATFLHGSWFEPLNSVNSEEKAVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARSF
LENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRYCS

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=282, Percent_Identity=33.6879432624113, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787463, Length=278, Percent_Identity=53.2374100719424, Blast_Score=279, Evalue=1e-76,
Organism=Escherichia coli, GI87082085, Length=220, Percent_Identity=30.9090909090909, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324266, Length=169, Percent_Identity=32.5443786982249, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24582226, Length=219, Percent_Identity=31.0502283105023, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32152; Mature: 32152

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSAYTVESALKSAIVQLQEGDNTSPSIDATVLLCHALDKPRSYLLTWPEKHLTSEQESE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEHHHCCCCCEEEECCHHHCCCCHHHH
FNTLLKRRLTGEPVAYIVGEREFWSLPLKVSPSTLIPRPDTERLVEVALDKTYGKQGAIL
HHHHHHHHCCCCCEEEEECCHHHEECCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
DLGTGTGAIALALASEMPNRPVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLNS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEECCCEEEECCCHHHHHHH
VNSEEKAVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARSF
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECHHHHEECCCCCCHHHHHHHHHHHHH
LENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRYCS
HHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCCC
>Mature Secondary Structure
MQSAYTVESALKSAIVQLQEGDNTSPSIDATVLLCHALDKPRSYLLTWPEKHLTSEQESE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEHHHCCCCCEEEECCHHHCCCCHHHH
FNTLLKRRLTGEPVAYIVGEREFWSLPLKVSPSTLIPRPDTERLVEVALDKTYGKQGAIL
HHHHHHHHCCCCCEEEEECCHHHEECCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
DLGTGTGAIALALASEMPNRPVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLNS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEECCCEEEECCCHHHHHHH
VNSEEKAVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARSF
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECHHHHEECCCCCCHHHHHHHHHHHHH
LENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRYCS
HHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]