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The map label for this gene is kcsA [H]

Identifier: 218708451

GI number: 218708451

Start: 420863

End: 421612

Strand: Reverse

Name: kcsA [H]

Synonym: VS_0414

Alternate gene names: 218708451

Gene position: 421612-420863 (Counterclockwise)

Preceding gene: 218708455

Following gene: 218708449

Centisome position: 12.78

GC content: 40.93

Gene sequence:

>750_bases
ATGTTAAATAGTATCAAAGACACCACTAAGCCGATGAGCTTATTATCACTGATTCTCTCTTTCTTAGCGTTATTTGTGAT
CTCAGGCTTATTGTTTGCACCTATTAATAAAGAATCGAAACAAGTTCTTATCGGCCTGGACTTTATAATCTGTAGCGTTT
TTCTTTTTCAGCTCACTATTGATCTATTCAGATCACAAAATAAGAAAGAATATCTAAAAGTACACTGGATCGATTTCTTG
GCAAGCATCCCTATGGTCGAGCCACTTCGATTCGCTCGCATTTTTCAGATCTTGCGCGTGATTCTCGTTCTTCGGTCAGG
AAAACGTGTTTTCAGAGAGCTGTTTCGCAATCGAAAAGAAACGACACTCGCCTCAATTATTTTGCTATTGGTTATTCTCC
TGACCATAGGTGCAGGAACAATACTGCTGCTAGAGCACAAGGACCCCAATGCCAACATTACCACTGGCCAAGATGCTTTA
TGGTGGGCTTTCGTAACGATTAGTACCGTGGGGTACGGCGATCATTATCCAGTAACGAGCTCAGGCAAGTTAGTCGCTTC
TCTGGTGATCATTTGTGGTGTGGGTGTTTTTGGTATGATTTCTGGGTTGATTACTTCTTTGATCACCTCTCCAACTCGCC
ATGAGAATCAACGAGCAGAAATCAAAGAGAAGCACCTTGAGAAGATCATTGAACAACAACAGAAAATCCTCGAACGACTA
GAAAAGCTAGAACAACAAACAAAAAAATAG

Upstream 100 bases:

>100_bases
CATTGTCAGTTCTCCATTAACTCTTATATATTGATGGCTTCTATATCCGCGAGATGGCTATGTCAGTCAAAGTTCGCGAT
TTATTTTGAGCCTCGTATGA

Downstream 100 bases:

>100_bases
GGCCGAAGCCCTATTTTCAATTTCATGTTGTTATGAAACTCAGTCTTGCCAATACGGCTCAACTTCTACACTTATTTGGC
GTGTCTGTTCCATCGCATGC

Product: putative potassium channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLNSIKDTTKPMSLLSLILSFLALFVISGLLFAPINKESKQVLIGLDFIICSVFLFQLTIDLFRSQNKKEYLKVHWIDFL
ASIPMVEPLRFARIFQILRVILVLRSGKRVFRELFRNRKETTLASIILLLVILLTIGAGTILLLEHKDPNANITTGQDAL
WWAFVTISTVGYGDHYPVTSSGKLVASLVIICGVGVFGMISGLITSLITSPTRHENQRAEIKEKHLEKIIEQQQKILERL
EKLEQQTKK

Sequences:

>Translated_249_residues
MLNSIKDTTKPMSLLSLILSFLALFVISGLLFAPINKESKQVLIGLDFIICSVFLFQLTIDLFRSQNKKEYLKVHWIDFL
ASIPMVEPLRFARIFQILRVILVLRSGKRVFRELFRNRKETTLASIILLLVILLTIGAGTILLLEHKDPNANITTGQDAL
WWAFVTISTVGYGDHYPVTSSGKLVASLVIICGVGVFGMISGLITSLITSPTRHENQRAEIKEKHLEKIIEQQQKILERL
EKLEQQTKK
>Mature_249_residues
MLNSIKDTTKPMSLLSLILSFLALFVISGLLFAPINKESKQVLIGLDFIICSVFLFQLTIDLFRSQNKKEYLKVHWIDFL
ASIPMVEPLRFARIFQILRVILVLRSGKRVFRELFRNRKETTLASIILLLVILLTIGAGTILLLEHKDPNANITTGQDAL
WWAFVTISTVGYGDHYPVTSSGKLVASLVIICGVGVFGMISGLITSLITSPTRHENQRAEIKEKHLEKIIEQQQKILERL
EKLEQQTKK

Specific function: Acts as a potassium ion channel [H]

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI26051262, Length=143, Percent_Identity=33.5664335664336, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI26051260, Length=143, Percent_Identity=33.5664335664336, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI26051266, Length=143, Percent_Identity=33.5664335664336, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI26051264, Length=143, Percent_Identity=33.5664335664336, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI26051268, Length=143, Percent_Identity=33.5664335664336, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI25952108, Length=217, Percent_Identity=29.4930875576037, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI119395748, Length=170, Percent_Identity=34.1176470588235, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI26638655, Length=209, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI88758565, Length=168, Percent_Identity=35.1190476190476, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI26638653, Length=209, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI236462242, Length=209, Percent_Identity=28.2296650717703, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI236462079, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI236461942, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI236461719, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI28373065, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI19424136, Length=113, Percent_Identity=35.3982300884956, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4504817, Length=117, Percent_Identity=39.3162393162393, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4504821, Length=112, Percent_Identity=41.0714285714286, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4758630, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71994134, Length=240, Percent_Identity=26.25, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71989381, Length=113, Percent_Identity=36.283185840708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193206869, Length=169, Percent_Identity=28.9940828402367, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989369, Length=113, Percent_Identity=36.283185840708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989361, Length=113, Percent_Identity=36.283185840708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989376, Length=113, Percent_Identity=36.283185840708, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25148255, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994313, Length=114, Percent_Identity=36.8421052631579, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147238, Length=140, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147242, Length=140, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330119, Length=121, Percent_Identity=33.8842975206612, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330117, Length=121, Percent_Identity=33.8842975206612, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363095, Length=121, Percent_Identity=33.8842975206612, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363097, Length=121, Percent_Identity=33.8842975206612, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656289, Length=265, Percent_Identity=23.0188679245283, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24656294, Length=265, Percent_Identity=23.0188679245283, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099
- InterPro:   IPR003091 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 28216; Mature: 28216

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSIKDTTKPMSLLSLILSFLALFVISGLLFAPINKESKQVLIGLDFIICSVFLFQLTI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DLFRSQNKKEYLKVHWIDFLASIPMVEPLRFARIFQILRVILVLRSGKRVFRELFRNRKE
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHH
TTLASIILLLVILLTIGAGTILLLEHKDPNANITTGQDALWWAFVTISTVGYGDHYPVTS
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
SGKLVASLVIICGVGVFGMISGLITSLITSPTRHENQRAEIKEKHLEKIIEQQQKILERL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKLEQQTKK
HHHHHHHCC
>Mature Secondary Structure
MLNSIKDTTKPMSLLSLILSFLALFVISGLLFAPINKESKQVLIGLDFIICSVFLFQLTI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DLFRSQNKKEYLKVHWIDFLASIPMVEPLRFARIFQILRVILVLRSGKRVFRELFRNRKE
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHH
TTLASIILLLVILLTIGAGTILLLEHKDPNANITTGQDALWWAFVTISTVGYGDHYPVTS
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
SGKLVASLVIICGVGVFGMISGLITSLITSPTRHENQRAEIKEKHLEKIIEQQQKILERL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKLEQQTKK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]