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The map label for this gene is mhpR [H]

Identifier: 218703633

GI number: 218703633

Start: 425949

End: 426896

Strand: Reverse

Name: mhpR [H]

Synonym: ECUMN_0389

Alternate gene names: 218703633

Gene position: 426896-425949 (Counterclockwise)

Preceding gene: 218703642

Following gene: 218703632

Centisome position: 8.21

GC content: 53.48

Gene sequence:

>948_bases
ATGATTTTTTATTGTGCGCTCAGTATAGGAAGGGTGTTTTCGGCTACAATCAAAACATGCCCGAATGTGCACCAGGTGCA
CAACGTTGTTTTAACTATAGAAATGTCAATTAATATGCAGAACAATGAGCAGACGGAATACAAAACCGTGCGCGGCTTAA
CCCGCGGTCTAATGTTATTAAATATGTTAAATAAACTTGATGGCGGTGCCAGCGTCGGGCTGCTGGCGGAACTCAGCGGC
CTGCATCGCACCACTGTGCGGCGACTGCTGGAGACGCTGCAGGAAGAGGGATATGTCCGGCGTAGTCCCTCCGATGACAG
TTTTCGTCTGACCATCAAAGTGCGGCAATTAAGCGAAGGATTTCGTGACGAACAGTGGATTTCTGCACTGGCGGCCCCAC
TGCTGGGCGATCTGTTGCGCGAAGTGGTATGGCCGACAGATGTGTCCACGCTGGATGTTGATGCAATGGTGGTACGCGAA
ACCACTCACCGTTTCAGCCGCTTATCCTTTCACCGGGCAATGGTCGGGCGACGTTTACCGCTCCTGAAAACCGCCTCGGG
CCTGACCTGGCTGGCCTTTTGCCCGGAACAAGAACGCAAGGAATTAATCGAGATGTTAGCCTCCCGCCCCGGTGATGACT
ATCAACTGGCACGGGAACCGTTAAAGCTGGAAGCCATTCTGGCGCGCGCGCGCAAAGAGGGGTACGGACAGAACTACCGC
GGCTGGGATCAAGAAGAAAAGATCGCCTCTATTGCCGTACCGCTGCGCAGTGAACAACGGGTGATTGGCTGTCTGAATCT
GGTGTATATGGCGAGCGCAATGACCATTGAACAGGCAGCGGAAAAGCATCTTCCGGCGCTACAACGGGTGGCAAAACAGA
TCGAAGAAGGGGTTGAATCGCAGGCTATTCTGGTGGCCGGACGGCGAAGCGGCATGCATTTACGTTGA

Upstream 100 bases:

>100_bases
GATGTCAGGGTGTTGTATTGCCATTTCAGTACCTCACGACTCGGACAAAATGCCGTTGCGCGCACAGTACAGCGCAACTT
ATTTTGTTAAAAACATGTAA

Downstream 100 bases:

>100_bases
CACCATCGAATGGCGCAAAACCTTTCGCGGTATGGCATGATAGCGCCCGGAAGAGAGTCAATTCAGGGTGGTGAATGTGA
AACCAGTAACGCTATACGAT

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGMHLR

Sequences:

>Translated_315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGMHLR
>Mature_315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGMHLR

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=277, Percent_Identity=99.6389891696751, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1789999, Length=143, Percent_Identity=32.1678321678322, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=27.4336283185841, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082359, Length=205, Percent_Identity=28.780487804878, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 35570; Mature: 35570

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLL
CEEEEEEHHHHHHHHHHHHCCCHHHHCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHCC
FRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYR
HHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCC
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVES
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
QAILVAGRRSGMHLR
CEEEEEECCCCCCCC
>Mature Secondary Structure
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLL
CEEEEEEHHHHHHHHHHHHCCCHHHHCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHCC
FRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLKLEAILARARKEGYGQNYR
HHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCC
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVES
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
QAILVAGRRSGMHLR
CEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]