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The map label for this gene is betA [H]

Identifier: 218703595

GI number: 218703595

Start: 378712

End: 380382

Strand: Reverse

Name: betA [H]

Synonym: ECUMN_0349

Alternate gene names: 218703595

Gene position: 380382-378712 (Counterclockwise)

Preceding gene: 218703596

Following gene: 218703594

Centisome position: 7.31

GC content: 57.87

Gene sequence:

>1671_bases
TTGCAATTTGACTACATCATTATTGGTGCCGGCTCAGCCGGCAACGTTCTCGCTACCCGTCTGACTGAAGATCCGAACAC
AACCGTGCTGCTGCTTGAAGCAGGCGGCCCGGACTATCGCTTTGACTTCCGCACCCAGATGCCCGCCGCGCTGGCATTCC
CGCTACAGGGTAAACGCTATAACTGGGCCTATGAGACGGAACCGGAACCGTTTATGAACAACCGTCGCATGGAGTGCGGA
CGCGGTAAGGGGCTTGGCGGGTCATCACTGATCAACGGCATGTGTTACATCCGTGGTAACGCGCTGGATCTCGATAACTG
GGCGCAAGAACCCGGTCTGGAGAACTGGAGTTATCTCGACTGCCTGCCCTACTACCGCAAGGCCGAGACTCGCGATGTAG
GCGAGAACGACTACCACGGTGGCGATGGCCCGGTGAGCGTCACTACCTCCAAACCCGGCGTCAATCCGCTGTTTGAAGCG
ATGATTGAAGCGGGCGTGCAGGCAGGCTACCCGCGCACGGACGATCTCAACGGCTATCAGCAGGAAGGTTTTGGCCCGAT
GGATCGCACCGTCACGCCGCATGGCCGTCGCGCCAGCACCGCGCGTGGCTATCTCGATCAGGCCAAATCGCGCCCTAACC
TGACCATTCGTACTCACGCCATGACCGATCACATCATTTTTGACGGCAAACGCGCGGTGGGCGTCGAGTGGCTGGAAGGC
GACAGCACCATTCCAACCCGCGCGACAGCGAATAAAGAGGTGCTGTTATGTGCAGGTGCGATCGCCTCTCCGCAGATCCT
GCAACGTTCCGGCGTGGGTAGCGCTGAACTGCTGGCGGAGTTTGATATTCCGCTGGTGCATGATTTACCCGGCGTCGGCG
AAAATCTTCAGGATCACCTGGAGATGTACCTGCAATATGAGTGCAAAGAACCGGTTTCCCTCTACCCTGCCCTGCAGTGG
TGGAATCAGCCGAAAATCGGTGCGGAGTGGCTGTTTGGCGGCACCGGCGTTGGTGCCAGCAACCACTTTGAAGCAGGCGG
ATTTATTCGCAGCCGTGAGGAATTTGCGTGGCCGAATATTCAGTACCATTTCCTGCCAGTGGCGATTAACTATAACGGCT
CGAACGCAGTGAAAGAGCACGGCTTCCAGTGCCACGTCGGATCGATGCGCTCGCCAAGCCGTGGGCATGTGCGGATTAAA
TCCCGCGACCCGCACCAGCATCCAGCGATTCTGTTTAACTACATGTCGCACGAGCAGGACTGGCAGGAGTTCCGCGACGC
AATTCGCATCACCCGCGAGATCATGCATCAACCGGCGCTGGATCAGTATCGTGGCCGCGAAATCAGCCCCGGTGTCGAAT
GCCAGACGGATGAGCAGCTCGATGAGTTCGTGCGTAACCACGCCGAAACCGCCTTCCACCCGTGCGGTACCTGCAAAATG
GGTTATGACGAGATGGCAGTGGTTGACGGCGAAGGCCGCGTACACGGGCTGGAAGGCCTGCGCGTGGTGGATGCGTCAAT
TATGCCGCAGATTATCACCGGCAATTTGAACGCCACGACTATTATGATTGGCGAGAAAATGGCGGATATGATTCGCGGGA
AGGATGCGTTGCCGAGGAGCACGGCGGGATATTATGTGGCAAATGGGAGGCCGGTGAGAGCGAAAAAATGA

Upstream 100 bases:

>100_bases
CGCGAGAACGGCGTGATGACGCTCCAGAGTTACACCCAGGTGAAGTCCATCCAGGTTGAGATGGCTAAATTCCAGTCCAT
ATTCTAACCAGGAGGTTTAT

Downstream 100 bases:

>100_bases
GTCGTGATGTGAACTGACTCAGGAACCTATCAGATTGAGAGTTACCGTTCTACTATGAGGACCGAATCCTTATATAAAAC
ACTGAGGTAACTCTCATGCT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGSAELLAEFDIPLVHDLPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGRPVRAKK

Sequences:

>Translated_556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGSAELLAEFDIPLVHDLPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGRPVRAKK
>Mature_556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGSAELLAEFDIPLVHDLPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGRPVRAKK

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=48.2504604051565, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1786503, Length=556, Percent_Identity=98.0215827338129, Blast_Score=1145, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=44.582593250444, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24642048, Length=573, Percent_Identity=35.4275741710297, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=36.077057793345, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=34.965034965035, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI45549471, Length=574, Percent_Identity=35.0174216027875, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=35.0174216027875, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=35.2941176470588, Blast_Score=268, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24642055, Length=586, Percent_Identity=34.4709897610922, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=33.7979094076655, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24650267, Length=578, Percent_Identity=33.0449826989619, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=34.2657342657343, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=33.6267605633803, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=32.1739130434783, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI18859993, Length=573, Percent_Identity=33.5078534031414, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24642037, Length=576, Percent_Identity=32.4652777777778, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24645930, Length=581, Percent_Identity=27.710843373494, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=29.0598290598291, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 61857; Mature: 61857

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPHGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGSAELLAEFDIPLVHDLPGVGENLQDHL
CCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHCCCCCEECCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHEEHHHHCHHH
WQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCCCCCCC
TAGYYVANGRPVRAKK
CCCEEEECCEECCCCC
>Mature Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPHGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGSAELLAEFDIPLVHDLPGVGENLQDHL
CCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHCCCCCEECCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHEEHHHHCHHH
WQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCCCCCCC
TAGYYVANGRPVRAKK
CCCEEEECCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA