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The map label for this gene is yeiA

Identifier: 218700619

GI number: 218700619

Start: 2349665

End: 2350900

Strand: Direct

Name: yeiA

Synonym: ECIAI39_2286

Alternate gene names: 218700619

Gene position: 2349665-2350900 (Clockwise)

Preceding gene: 218700618

Following gene: 218700626

Centisome position: 45.78

GC content: 50.49

Gene sequence:

>1236_bases
ATGTTAACGAAAGATCTTTCGATTACTTTTTGCGGCGTGAAGTTTCCCAACCCGTTCTGCCTCTCTTCTTCGCCGGTAGG
CAACTGCTATGAGATGTGTGCCAAAGCCTACGACACTGGCTGGGGCGGCGTGGTGTTTAAAACGATCGGCTTTTTTATCG
CCAACGAAGTCTCGCCGCGTTTTGATCATCTGGTGAAAGAAGATACCGGTTTTATCGGCTTCAAAAATATGGAGCAGATT
GCTGAACATCCGTTGGAAGATAATCTGGCCGCCCTGCGTCGGCTGAAAGAAGATTATCCGGACAAAGTATTGATCGCTTC
AATCATGGGCGAAAATGAGCAGCAATGGGAAGAGCTGGCGCGTCTGGTGCAAGAAGCTGGCGCGGATATGATCGAGTGTA
ACTTCTCCTGCCCGCAAATGACTTCTCATGCGATGGGGAGCGATGTCGGGCAAAGCCCGGAACTGGTAGAAAAATATTGT
CGGGCAGTGAAACGTGGTTCCACGCTGCCAATGCTGGCGAAGATGACGCCGAATATCGGTGATATGTGCGAAGTGGCGCT
GGCGGCGAAGCGCGGCGGCGCAGATGGCATTGCGGCGATTAACACCGTTAAATCCATCACCAATATCGATCTTAATCAGA
AAATCGGTATGCCGATCGTTAACGGTAAATCGAGTATTTCCGGATATTCCGGTAAAGCGGTAAAACCGATCGCCCTGCGC
TTTATTCAGCAAATGCGTACCCATCCAGAGCTGCGCGATTTCCCGATCAGCGGTATCGGCGGCATTGAAACCTGGGAAGA
TGCGGCGGAGTTTTTATTGCTCGGCGCAGCAACGTTACAGGTCACCACCGGCATTATGCAGTACGGCTATCGCATCGTAG
AAGATATGGCGAGCGGGTTGTCGCATTATCTCGCCGATCAGGGATTTGATTCGTTGCAGGAGATGGTAGGTCTGGCGAAT
AACAATATTGTCCCGGCGGAAGATTTAGACCGCAGTTATATTGTCTATCCCCATATCAATCTCGATAAATGTGTTGGCTG
TGGACGCTGTTATATTTCCTGTTACGACGGCGGTCACCAGGCGATGGAATGGAGCGAGAAAACCCGTACACCGCATTGTA
ATACCGAGAAATGTGTGGGTTGCCTGCTTTGTGGTCACGTCTGCCCGGTGGGTTGTATTGATCTCGGAGAAGTGAAGTTT
AAGAAGGGAGAGAAAGAACACCCGGTAACGTTGTAA

Upstream 100 bases:

>100_bases
CTGGCGATATTGTTGAGGGTGACAAAACCGTGGTCTATGCCGTGAAAACCGGGAAAGAAGCCGCCGAGGCGATTCATCAC
TATTTAGAGGGAGCTTGCTC

Downstream 100 bases:

>100_bases
AATCAGAGACGCATCCGGCATTTGGCACCGATTGCCGGATGCGACGCATCCGGCAATACCCACATTCACATCATTTCTTA
CGCGCGTACTTCAGTGAATC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEDNLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
NNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL

Sequences:

>Translated_411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEDNLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
NNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL
>Mature_411_residues
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI
AEHPLEDNLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN
NNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKF
KKGEKEHPVTL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=328, Percent_Identity=35.9756097560976, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=99.2700729927007, Blast_Score=852, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=475, Percent_Identity=33.6842105263158, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6322633, Length=241, Percent_Identity=27.8008298755187, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640763, Length=315, Percent_Identity=38.7301587301587, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI18858217, Length=315, Percent_Identity=38.7301587301587, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45022; Mature: 45022

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLVKEDTGFIGFKNMEQIAEHPLEDNLAALRRLKEDYPDKVLIASIMGENEQQWEELA
HHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHH
RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCCCH
AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLVKEDTGFIGFKNMEQIAEHPLEDNLAALRRLKEDYPDKVLIASIMGENEQQWEELA
HHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHH
RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQ
HHHHHHCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCCCH
AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]