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The map label for this gene is csgD

Identifier: 218700457

GI number: 218700457

Start: 2164308

End: 2164958

Strand: Direct

Name: csgD

Synonym: ECIAI39_2123

Alternate gene names: 218700457

Gene position: 2164308-2164958 (Clockwise)

Preceding gene: 218700450

Following gene: 218700458

Centisome position: 42.17

GC content: 42.4

Gene sequence:

>651_bases
ATGTTTAATGAAGTCCATAGTATTCATGGTCATACATTATTGTTGATCACTAAACCTTCTTTGCAGGCGGCAGCTCTCTT
GCAGCACCTTAAACAATCGCTGGCAATTACAGGAAAATTACATAATATTCAACGTTCTCTGGACGATATCTCTTCAGGCT
CTATTATTCTTCTGGATATGATGGAAGCGGATAAAAAGCTTATCCATTATTGGCAGGATACTTTGAGCAGGAAAAACAAC
AATATCAAAATATTGTTGCTAAATACGCCTGAAGATTACCCGTACCGCGACATTGAAAACTGGCCTCATATCAACGGCGT
TTTTTATGCCATGGAGGATCAAGAACGTGTTGTCAATGGGTTGCAAGGCGTCCTGCGCGGCGAATGCTACTTTACGCAAA
AGCTTGCCAGCTACCTGATTACGCATTCGGGTAACTATCGTTATAACAGCACGGAATCAGCCCTCCTTACTCATCGGGAA
AAAGAGATCCTGAATAAGCTGCGTATCGGCGCGTCTAATAACGAGATCGCTCGTTCGTTGTTCATCAGCGAAAATACGGT
TAAAACGCATCTTTATAACCTTTTCAAGAAGATAGCTGTAAAAAACCGGACACAAGCGGTTTCCTGGGCAAACGATAACC
TCAGGCGATAA

Upstream 100 bases:

>100_bases
TTACTACACACAGCAGTGCAACATCTGTCAGTACTTCTGGTGCTTCTATTTTAGAGGCAGCTGTCAGGTGTGCGATCAAT
AAAAAAAGCGGGGTTTCATC

Downstream 100 bases:

>100_bases
AGCCATGAAACGTTATTTACGCTGGATTGTGGCGGCAGAATTTCTGTTCGCCGCAGGGAATCTTCACGCCGTTGAGGTAG
AAGTCCCGGGATTGTTAACT

Product: DNA-binding transcriptional regulator CsgD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNN
NIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHRE
KEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR

Sequences:

>Translated_216_residues
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNN
NIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHRE
KEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR
>Mature_216_residues
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNN
NIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHRE
KEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR

Specific function: The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA t

COG id: COG2771

COG function: function code K; DNA-binding HTH domain-containing proteins

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH luxR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787277, Length=216, Percent_Identity=98.6111111111111, Blast_Score=439, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016032
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE [H]

EC number: NA

Molecular weight: Translated: 24900; Mature: 24900

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDM
CCCCHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
MEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSL
HHHHHHCCHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR
HHCCCHHHHHHHHHHHHHHHCCCHHEEEECCCCCCC
>Mature Secondary Structure
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDM
CCCCHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
MEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSL
HHHHHHCCHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR
HHCCCHHHHHHHHHHHHHHHCCCHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8817489; 8905232; 9278503 [H]