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The map label for this gene is tdk

Identifier: 218699944

GI number: 218699944

Start: 1643716

End: 1644333

Strand: Direct

Name: tdk

Synonym: ECIAI39_1573

Alternate gene names: 218699944

Gene position: 1643716-1644333 (Clockwise)

Preceding gene: 218699942

Following gene: 218699947

Centisome position: 32.03

GC content: 43.04

Gene sequence:

>618_bases
ATGGCACAGCTATATTTCTACTATTCCGCAATGAATGCGGGTAAGTCTACAGCATTGTTGCAATCTTCATACAATTACCA
GGAACGCGGCATGCGCACTGTCGTATATACGGCAGAAATTGATGATCGCTTTGGTGCCGGGAAAGTCAGCTCGCGTATAG
GTTTGTCATCGCCTGCAAAATTATTTAACCAAAATTCATCATTATTTGATGAGATTCGTGCGGAACATGAACAGCAGGCA
ATTCATTGCGTACTGGTTGATGAATGCCAGTTTTTAACCAGACAACAAGTATATGAATTATCGGAGGTTGTCGATCAACT
CGATATACCCGTACTTTGTTATGGTTTACGTACCGATTTTCGAGGTGAGTTATTTATTGGCAGCCAATACTTACTGGCAT
GGTCCGACAAACTGGTTGAATTAAAAACCATCTGTTTTTGTGGCCGCAAAGCAAGCATGGTGCTGCGTCTTGATCAAGCA
GGCAGACCTTATAACGAAGGTGAGCAGGTGGTTATTGGTGGTAATGAACGCTACGTTTCTGTATGCCGTAAACACTATAA
AGAGGCGTTAGAAGTCGGCTCATTAACGGCTATTCAGGAAAGGCATCGCCACGATTAA

Upstream 100 bases:

>100_bases
ACGCATATACCACTTCTGTGCATACTGTTGAGCTGAAAAACTGACGAATTATGATAAACTCCAGCCAACTTTAATTCATA
TCATTGAGGGCCTGTGGCTG

Downstream 100 bases:

>100_bases
TAAGAATTTCTTTACTGACAGGGTGAGCAGGGCGCTTTTATCCTGTCAGTTCGTTTTACTCACTTCATCCGGTGTATATA
CCTTCTCGACAGTTCTTTAA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALEVGSLTAIQERHRHD

Sequences:

>Translated_205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALEVGSLTAIQERHRHD
>Mature_204_residues
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQAI
HCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAG
RPYNEGEQVVIGGNERYVSVCRKHYKEALEVGSLTAIQERHRHD

Specific function: Phosphorylates both thymidine and deoxyuridine [H]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787490, Length=205, Percent_Identity=99.0243902439024, Blast_Score=422, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634 [H]

Pfam domain/function: PF00265 TK [H]

EC number: =2.7.1.21 [H]

Molecular weight: Translated: 23400; Mature: 23269

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CCEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALEVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALEVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]