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Identifier: 218699810

GI number: 218699810

Start: 1504012

End: 1505013

Strand: Reverse

Name: add

Synonym: ECIAI39_1434

Alternate gene names: 218699810

Gene position: 1505013-1504012 (Counterclockwise)

Preceding gene: 218699811

Following gene: 218699808

Centisome position: 29.33

GC content: 53.79

Gene sequence:

>1002_bases
ATGATTGATACCACCCTGCCATTAACTGATATCCATCGCCACCTTGATGGCAACATTCGTCCCCAGACCATTCTTGAACT
TGGCCGCCAGTATAATATCTCGCTTCCTGCACAATCCCTGGAAACACTGATTCCCCACGTTCAGGTCATTGCCAACGAAC
CCGATCTTGTGAGCTTTCTGACCAAACTTGACTGGGGCGTTAAAGTTCTCGCCTCTCTTGATGCCTGTCGCCGCGTGGCA
TTTGAAAACATTGAAGATGCAGCCCGTCACGGCCTGCACTATGTCGAGCTGCGTTTTTCACCGGGCTACATGGCAATGGC
TCATCAGCTGCCTGTAGCGGGTGTTGTCGAAGCGGTGATCGATGGCGTATGTGAAGGTTGCCGTACCTTTGGTGTGCAGG
CGAAGCTTATCGGCATTATGAGCCGGACCTTCGGTGAAGCCGCCTGTCAGCAAGAGCTGGAGGCCTTTTTAGCCCACCGT
GACCAGATTACCGCACTTGATTTAGCCGGTGATGAACTTGGTTTCCCGGGAAGTCTGTTTCTTTCTCACTTCAACCGCGC
GCGTGATGCGGGCTGGCATATTACCGTCCATGCAGGCGAAGCTGCCGGGCCGGAAAGCATCTGGCAGGCGATTCGTGAAC
TGGGGGCGGAACGTATTGGACATGGCGTAAAAGCCATTGAAGATCGGGCGCTGATGGATTTTCTCGCCGAGCAACAAATT
GGTATTGAATCCTGTCTGACCTCCAATATTCAGACCAGCACCGTGGCAGAGCTGGCGGCACATCCGCTGAAAATGTTCCT
TGAGCATGGCATTCGTGCCAGCATTAACACTGACGATCCCGGCGTACAGGGAGTGGATATCATTCACGAATATACCGTTG
CCGCGCCGGCTGCTGGGTTATCCCGCGAGCAAATCCGCCAGGCGCAGATTAATGGTCTGGAAATGGCTTTCCTCAGCGCA
GAGGAAAAACGCGCACTGCGAGAAAAAGTCGCCGCGAAGTAA

Upstream 100 bases:

>100_bases
CAATTGCGCAACGTAAAAAATCGTTGCGCAATCGTGGATTTTTACCCTGCTTTGTTTTTATAATGGTGCGCACTTTTATA
TCCAGAAAAAGAGTGCGACC

Downstream 100 bases:

>100_bases
CAAAAATGGATGGTGCTAATTGCACCATCCTCTTTTCACGCAAGGCACAGCGTCGCGCGATGTTTGGCGGATTCGATGCC
CAGCTCAATCAACTCCATTA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVA
FENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHR
DQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQI
GIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSA
EEKRALREKVAAK

Sequences:

>Translated_333_residues
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVA
FENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHR
DQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQI
GIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSA
EEKRALREKVAAK
>Mature_333_residues
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVA
FENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHR
DQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQI
GIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSA
EEKRALREKVAAK

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=339, Percent_Identity=33.0383480825959, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1787910, Length=333, Percent_Identity=99.3993993993994, Blast_Score=674, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538512, Length=339, Percent_Identity=30.0884955752212, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI32565969, Length=339, Percent_Identity=30.0884955752212, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324188, Length=338, Percent_Identity=26.6272189349112, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645260, Length=335, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006650
- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 36375; Mature: 36375

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00485 A_DEAMINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFL
CCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCHHHHHHHHH
DGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLF
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
LSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGL
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCC
SREQIRQAQINGLEMAFLSAEEKRALREKVAAK
CHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFL
CCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCHHHHHHHHH
DGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLF
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
LSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGL
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCC
SREQIRQAQINGLEMAFLSAEEKRALREKVAAK
CHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA