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The map label for this gene is galM

Identifier: 218699121

GI number: 218699121

Start: 766644

End: 767684

Strand: Reverse

Name: galM

Synonym: ECIAI39_0724

Alternate gene names: 218699121

Gene position: 767684-766644 (Counterclockwise)

Preceding gene: 218699122

Following gene: 218699120

Centisome position: 14.96

GC content: 55.62

Gene sequence:

>1041_bases
GTGCTGAACGAAACTCCCGCACTGGCACCCGATGGTCAGCCGTACCGACTGTTAACTTTGCGTAACAACGCAGGGATGGT
AGTCACGCTGATGGACTGGGGTGCGACTTTACTTTCCGCCCGTATTCCGCTTTCCGATGGCAGCGTCCGCGAGGCGCTGC
TTGGCTGCGCCAGCCCGGAATGCTATCAGGATCAGGCCGCATTTCTGGGGGCCTCTATTGGTCGTTATGCCAACCGCATC
GCCAATAGCCGTTATACCTTTGACGGTGAAACCGTGACGCTTTCGCCAAGTCAGGGCGTTAACCAGCTGCACGGCGGCCC
GGAAGGGTTCGACAAACGTCGCTGGCAGATTGTGAACCAGAATGATCGTCAGGTGCTATTTGCCCTGAGTTCAGATGATG
GCGATCAGGGCTTCCCGGGTAATCTCGGCGCGACGGTGCAATATCGTCTGACCGACGATAACCGTATCTCCATTACTTAT
CGCGCCACAGTTGATAAACCTTGCCCGGTGAATATGACTAATCACGTCTATTTCAACCTCGACGGCGAGCAGTCTGACGT
GCGCAATCACAAGTTGCAGATTCTGGCGGACGAATATCTGCCGGTTGATGAAGGCGGCATTCCGCACGACGGTCTGAAAT
CTGTCGCCGGAACATCTTTTGATTTCCGCAGCGCCAAAATCATCGCCAGTGAGTTTCTTGCCGACGACGATCAGCGCAAA
GTGAAAGGTTACGATCACGCGTTCTTGTTACAGGCCAAAGGCGATGGCAAGAAAGTGGCGGCGCATGTCTGGTCAGCAGA
TGAAAAATTGCAGCTGAAGGTCTACACCACCGCTCCGGCTCTGCAATTCTACTCCGGCAACTTCCTCGGCGGCACACCGT
CGCGGGGAACCGAACCTTACGCCGACTGGCAAGGGCTGGCTCTGGAAAGCGAATTTCTGCCGGACAGCCCGAACCACCCT
GAATGGCCGCAACCGGACTGCTTCCTGCGTCCTGGCGAAGAGTATTCCAGCCTGACGGAATATCAGTTTATTGCTCAGTA
A

Upstream 100 bases:

>100_bases
TGGTGCCTGCAGTACAGCAAGCTGTCGCTGAACAATATGAAGCAAAAACAGGTATTAAAGAGACTTTTTACGTTTGTAAA
CCATCACAAGGAGCAGGACA

Downstream 100 bases:

>100_bases
TGTTAAGCCCTCGTCATGAGGGCTTTATCCTCATATTGTTCAAATCACCAGCAAACACCGACATATTTGCAACTCAATAT
TCACAACAACCTTACACTGC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSLTEYQFIAQ

Sequences:

>Translated_346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSLTEYQFIAQ
>Mature_346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSLTEYQFIAQ

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=322, Percent_Identity=37.5776397515528, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1786971, Length=346, Percent_Identity=99.7109826589595, Blast_Score=717, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=32.8267477203647, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=32.8267477203647, Blast_Score=194, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319493, Length=348, Percent_Identity=25, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=27.7310924369748, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324399, Length=352, Percent_Identity=24.7159090909091, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24668278, Length=335, Percent_Identity=33.7313432835821, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24659048, Length=342, Percent_Identity=34.5029239766082, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24583720, Length=333, Percent_Identity=32.1321321321321, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641876, Length=357, Percent_Identity=28.0112044817927, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=28.5294117647059, Blast_Score=134, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38190; Mature: 38190

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEHEEECCCCCCHHHHHHHHCCCCH
CYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQ
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCHHHHCCCCCCCCCCEEEEECC
NDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
CCCHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPY
HCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCCCCCCCCC
ADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAQ
CCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHEEEECC
>Mature Secondary Structure
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEHEEECCCCCCHHHHHHHHCCCCH
CYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQ
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCHHHHCCCCCCCCCCEEEEECC
NDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
CCCHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
VKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPY
HCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCCCCCCCCC
ADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQFIAQ
CCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]