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The map label for this gene is ilvY

Identifier: 218697491

GI number: 218697491

Start: 4337222

End: 4338115

Strand: Reverse

Name: ilvY

Synonym: EC55989_4245

Alternate gene names: 218697491

Gene position: 4338115-4337222 (Counterclockwise)

Preceding gene: 218697493

Following gene: 218697484

Centisome position: 84.16

GC content: 57.83

Gene sequence:

>894_bases
TTGGATTTACGCGATCTGAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCGATGCACGT
TAGCCCATCCACGCTCTCACGGCAGATTCAGCGCCTGGAAGAAGATCTTGGTCAGCCGCTATTTGTGCGCGATAACCGCA
CGGTAACGCTGACGGAAGCGGGCGAAGAGCTGCGCGTTTTCGCCCAGCAAACGCTGTTGCAGTATCAGCAATTGCGCCAC
ACCATCGATCAGCAAGGGCCGTCGCTCTCTGGCGAATTACATATCTTCTGCTCGGTGACCGCTGCCTACAGCCATCTGCC
GCCGATTCTGGATCGCTTCCGCGCGGAACACCCGTCGGTGGAGATCAAACTCACCACTGGTGATGCGGCAGATGCAATGG
AAAAAGTGGTCACGGGAGAAGCGGATCTGGCGATTGCCGGGAAACCGGAGACGCTACCCGGCGCTGTGGCGTTTTCGATG
CTGGAGAATCTGGCAGTAGTGCTGATTGCGCCCGCGCTGCCCTGCCCGGTGCGTAACCAGGTTTCGGCAGAGAAGCCGGA
CTGGTCTACAGTGCCGTTTATCATGGCCGATCAGGGACCGGTGCGTCGCCGCATTGAACTGTGGTTTCGACGCAATAAAA
TCAGCAACCCGATGATTTACGCCACGGTTGGCGGGCATGAAGCGATGGTATCGATGGTGGCGCTCGGCTGTGGTGTGGCG
CTGTTGCCGGAAGTAGTGCTGGAAAACAGCCCCGAACCGGTGCGTAACCGCGTGATGATTTTAGAGCGCAGCGATGAAAA
AACGCCGTTTGAACTGGGCGTGTGTGCACAAAAAAAGCGGCTGCATGAGCCGCTGATTGAGGCGTTCTGGAGGATTTTGC
CGAACCACAAATGA

Upstream 100 bases:

>100_bases
AGATTGAATTCACTATATGACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTCACATTGCAATTTTTGCAACGT
CAACATCGAGGGCTGCGCCA

Downstream 100 bases:

>100_bases
CGTTGTCGCGCGGGTAGGCCTGATAAGCGAAGCGCTATCAGGCATTTTTCCCTAACCCGCCAAAAAGAACCTGAACGCCG
GGTTATTGGTTTCGTCGTGG

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWRILPNHK

Sequences:

>Translated_297_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWRILPNHK
>Mature_297_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWRILPNHK

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=297, Percent_Identity=99.3265993265993, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.5019157088123, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=28.8, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=29.2490118577075, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI157672245, Length=179, Percent_Identity=32.9608938547486, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=25.390625, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=29.3413173652695, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=26.4227642276423, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=27.5590551181102, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.2758620689655, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790262, Length=299, Percent_Identity=25.4180602006689, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.8995983935743, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788748, Length=295, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787530, Length=270, Percent_Identity=22.2222222222222, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=39.0243902439024, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788706, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=168, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=131, Percent_Identity=35.1145038167939, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33205; Mature: 33205

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWRILPNHK
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWRILPNHK
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]