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The map label for this gene is hdfR

Identifier: 218697482

GI number: 218697482

Start: 4327421

End: 4328260

Strand: Reverse

Name: hdfR

Synonym: EC55989_4237

Alternate gene names: 218697482

Gene position: 4328260-4327421 (Counterclockwise)

Preceding gene: 218697484

Following gene: 218697481

Centisome position: 83.96

GC content: 48.81

Gene sequence:

>840_bases
GTGGATACGGAATTGTTAAAAACTTTCCTGGAAGTTAGCCGAACGCGTCACTTTGGTCGAGCGGCTGAATCGCTCTATCT
GACCCAGTCAGCAGTGAGCTTTCGAATCAGACAACTGGAAAATCAACTGGGTGTGAACCTTTTCACCCGCCACAGAAACA
ATATCCGTTTAACCGCTGCCGGTGAAAAACTACTGCCTTATGCAGAAACGCTCATGAGCACCTGGCAGGCCGCCCGCAAG
GAGGTGGCGCATACCTCACGACATAACGAGTTTTCTATCGGTGCCAGCGCCTCGTTGTGGGAATGTATGCTTAATCAGTG
GCTGGGACGCTTGTATCAAAATCAGGATGCCCATACAGGCTTACAGTTCGAAGCGCGAATTGCCCAACGGCAGTCTCTGG
TAAAACAGCTGCATGAACGCCAGCTTGATCTTCTTATTACCACTGAAGCGCCCAAAATGGACGAATTTAGTAGTCAGTTG
CTGGGGTATTTCACTTTAGCGCTTTATACCAGTGCCCCTTCTAAACTAAAGGGAGATCTTAACTATCTGCGACTGGAGTG
GGGGCCAGATTTTCAACAGCATGAGGCAGGTTTGATCGGTGCTGACGAAGTGCCCATTCTGACAACCAGTTCTGCTGAAC
TGGCACAGCAACAGATTGCGATGCTTAATGGTTGCACCTGGCTACCCGTCAGCTGGGCGCGTAAAAAAGGCGGCCTGCAT
ACCGTTGTCGATAGCACAACACTTTCACGGCCGCTTTATGCCATATGGCTGCAAAATAGCGATAAAAATACGTTGATTCG
CGATCTATTGAAAATTAACGTGCTGGATGAAGTGTATTAA

Upstream 100 bases:

>100_bases
TTTGACCGAGCTAGTTATGGCGCGGAGTATTAGTTACGCTTGACAGAGTGTAAAACAAAACATTTAAATCATAACGACAA
ATAATTTTGCGGAGAGCACT

Downstream 100 bases:

>100_bases
TATGAATGGCTGGCAAGGATGCCGGTAGAAGGATTTACTTCAGAGAGGGTTATTTCAGATAAAAAAAATCCTTAGCTTTC
GCTAAGGATGATTTCTGGCA

Product: transcriptional regulator HdfR

Products: NA

Alternate protein names: H-NS-dependent flhDC regulator

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARK
EVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQL
LGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLH
TVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY

Sequences:

>Translated_279_residues
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARK
EVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQL
LGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLH
TVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY
>Mature_279_residues
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARK
EVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQL
LGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLH
TVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY

Specific function: Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI48994962, Length=279, Percent_Identity=99.6415770609319, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1788626, Length=151, Percent_Identity=30.4635761589404, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367136, Length=177, Percent_Identity=30.5084745762712, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790399, Length=265, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790208, Length=68, Percent_Identity=44.1176470588235, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787601, Length=158, Percent_Identity=27.2151898734177, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HDFR_ECO24 (A7ZTW7)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001465246.1
- ProteinModelPortal:   A7ZTW7
- STRING:   A7ZTW7
- EnsemblBacteria:   EBESCT00000020169
- GeneID:   5586547
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_4276
- eggNOG:   COG0583
- GeneTree:   EBGT00050000008341
- HOGENOM:   HBG536341
- OMA:   LHVGLPG
- ProtClustDB:   PRK03601
- BioCyc:   ECOL331111:ECE24377A_4276-MONOMER
- HAMAP:   MF_01233
- InterPro:   IPR020890
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 31777; Mature: 31777

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEC
GEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
LQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDL
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCC
NYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLH
EEEEEECCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEE
TVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY
EEECCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEC
GEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
LQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDL
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCC
NYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLH
EEEEEECCCCHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEE
TVVDSTTLSRPLYAIWLQNSDKNTLIRDLLKINVLDEVY
EEECCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA