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The map label for this gene is dgoT

Identifier: 218697413

GI number: 218697413

Start: 4245599

End: 4246891

Strand: Reverse

Name: dgoT

Synonym: EC55989_4160

Alternate gene names: 218697413

Gene position: 4246891-4245599 (Counterclockwise)

Preceding gene: 218697414

Following gene: 218697411

Centisome position: 82.39

GC content: 53.13

Gene sequence:

>1293_bases
ATGGATATTCCCGTTAATGCAGCAAAGCCGGGGCGTCGGCGTTATCTGACGCTGGTGATGATCTTTATTACGGTGGTCAT
TTGTTATGTTGACCGCGCTAACCTGGCCGTGGCTTCCGCCCATATTCAGGAAGAGTTCGGCATTACGAAAGCGGAAATGG
GCTATGTATTTTCGGCCTTCGCCTGGCTTTATACGCTATGCCAGATCCCCGGCGGTTGGTTTTTAGATCGCGTAGGTTCT
CGCGTGACTTATTTTATTGCGATATTTGGTTGGTCAGTGGCGACTTTATTCCAGGGCTTTGCCACGGGATTAATGTCATT
AATTGGTCTGCGTGCGATAACCGGTATTTTCGAAGCGCCCGCTTTCCCGACCAATAACCGGATGGTGACCAGCTGGTTCC
CGGAACATGAACGCGCTTCCGCCGTTGGTTTTTATACGTCTGGTCAGTTTGTCGGTCTGGCGTTTTTGACTCCGCTGCTG
ATCTGGATTCAGGAGATGTTGAGCTGGCACTGGGTGTTCATTGTCACTGGTGGTATCGGCATTATCTGGTCGCTGATTTG
GTTTAAGGTTTATCAGCCGCCGCGCCTGACCAAAGGTATCAGCAAAGCTGAACTGGATTACATTCGTGATGGCGGCGGTC
TGGTGGATGGTGATGCGCCGGTGAAGAAAGAGGCGCGTCAGCCGTTAACAGCCAAAGACTGGAAACTGGTGTTCCATCGT
AAACTGATCGGCGTTTATCTTGGGCAATTTGCGGTGGCTTCTACACTGTGGTTTTTCTTAACCTGGTTCCCGAACTATTT
AACCCAGGAAAAAGGAATCACGGCGCTGAAAGCAGGCTTTATGACCACGGTGCCATTCCTCGCGGCGTTTGTCGGCGTCC
TGCTCTCTGGCTGGGTCGCGGATCTGCTGGTACGTAAGGGCTTTTCACTGGGCTTTGCGCGTAAAACGCCGATTATCTGC
GGCTTGCTGATCTCCACCTGCATTATGGGCGCTAACTACACCAACGATCCGATGATGATTATGTGCCTGATGGCGCTGGC
ATTCTTCGGCAACGGTTTTGCTTCGATTACCTGGTCGCTGGTCTCTTCTCTGGCACCGATGCGCCTGATTGGTTTAACCG
GCGGCGTGTTTAACTTCGCCGGTGGTCTGGGCGGCATCACCGTTCCGCTGGTGGTGGGGTACCTGGCGCAGGGTTACGGT
TTCGCACCTGCACTGGTTTATATCTCCGCCGTCGCGTTGATTGGCGCGCTCTCTTACATCCTGCTGGTGGGCGATGTGAA
GCGCGTTGGCTAA

Upstream 100 bases:

>100_bases
TCATCGGGCACTAAAACAGCAATACAAAAATATAACCCTCTGTAAATTACAGGGCATGGTGAGCGGCTTCGCTATGCCCA
AAATCTGGAGAAAGCTCGCT

Downstream 100 bases:

>100_bases
TCTTTCAACTGTGGAATATGCGCCATACCACTGCGCATAATCCACTTTCTTAAAGCCGGTGCGGTCAGGCATCGGCTTTT
TACTATCTTGCCGAAGAGTT

Product: D-galactonate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGS
RVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLL
IWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHR
KLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIIC
GLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG
FAPALVYISAVALIGALSYILLVGDVKRVG

Sequences:

>Translated_430_residues
MDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGS
RVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLL
IWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHR
KLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIIC
GLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG
FAPALVYISAVALIGALSYILLVGDVKRVG
>Mature_430_residues
MDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGS
RVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLL
IWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHR
KLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIIC
GLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG
FAPALVYISAVALIGALSYILLVGDVKRVG

Specific function: Intake of galactonate into the cell

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family

Homologues:

Organism=Homo sapiens, GI6912666, Length=420, Percent_Identity=25.4761904761905, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI154350196, Length=412, Percent_Identity=24.2718446601942, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI9945322, Length=410, Percent_Identity=25.3658536585366, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21322234, Length=407, Percent_Identity=23.8329238329238, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI9966811, Length=408, Percent_Identity=23.7745098039216, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI148743791, Length=389, Percent_Identity=26.9922879177378, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148728191, Length=309, Percent_Identity=27.5080906148867, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI223718438, Length=215, Percent_Identity=26.046511627907, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI5031955, Length=264, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082320, Length=430, Percent_Identity=100, Blast_Score=862, Evalue=0.0,
Organism=Escherichia coli, GI1789152, Length=435, Percent_Identity=42.5287356321839, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1789515, Length=435, Percent_Identity=40.9195402298851, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI2367379, Length=435, Percent_Identity=29.4252873563218, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI2367193, Length=410, Percent_Identity=26.8292682926829, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788573, Length=437, Percent_Identity=23.5697940503432, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082071, Length=423, Percent_Identity=21.7494089834515, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082404, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533554, Length=424, Percent_Identity=25, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI115533556, Length=423, Percent_Identity=25.0591016548463, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71997452, Length=407, Percent_Identity=24.0786240786241, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535049, Length=427, Percent_Identity=23.6533957845433, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17552542, Length=431, Percent_Identity=24.1299303944316, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560030, Length=377, Percent_Identity=25.7294429708223, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25141318, Length=203, Percent_Identity=26.1083743842365, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25141341, Length=189, Percent_Identity=26.4550264550265, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86561091, Length=203, Percent_Identity=26.1083743842365, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25141316, Length=203, Percent_Identity=26.1083743842365, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32565916, Length=263, Percent_Identity=22.8136882129278, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565914, Length=263, Percent_Identity=22.8136882129278, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554148, Length=361, Percent_Identity=23.8227146814404, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17554962, Length=332, Percent_Identity=24.0963855421687, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193205400, Length=239, Percent_Identity=23.4309623430962, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45550460, Length=318, Percent_Identity=25.1572327044025, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24648416, Length=409, Percent_Identity=25.1833740831296, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356189, Length=409, Percent_Identity=25.1833740831296, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24655255, Length=285, Percent_Identity=25.6140350877193, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573299, Length=410, Percent_Identity=23.4146341463415, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24658658, Length=410, Percent_Identity=24.1463414634146, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655271, Length=408, Percent_Identity=23.0392156862745, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130135, Length=408, Percent_Identity=23.0392156862745, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130167, Length=439, Percent_Identity=23.6902050113895, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62484226, Length=404, Percent_Identity=24.009900990099, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24639764, Length=334, Percent_Identity=24.5508982035928, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573708, Length=342, Percent_Identity=22.2222222222222, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573707, Length=342, Percent_Identity=22.2222222222222, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24658674, Length=410, Percent_Identity=23.4146341463415, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24654215, Length=424, Percent_Identity=24.7641509433962, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922400, Length=424, Percent_Identity=24.7641509433962, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550495, Length=406, Percent_Identity=22.4137931034483, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24653727, Length=387, Percent_Identity=25.3229974160207, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583789, Length=380, Percent_Identity=22.1052631578947, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641682, Length=387, Percent_Identity=23.2558139534884, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580790, Length=373, Percent_Identity=25.201072386059, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920686, Length=390, Percent_Identity=22.0512820512821, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584153, Length=300, Percent_Identity=21.6666666666667, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658689, Length=410, Percent_Identity=22.4390243902439, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552797, Length=410, Percent_Identity=22.4390243902439, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129235, Length=273, Percent_Identity=24.1758241758242, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550364, Length=220, Percent_Identity=22.7272727272727, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281361682, Length=346, Percent_Identity=22.2543352601156, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DGOT_ECOL6 (P0AA77)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_756473.1
- ProteinModelPortal:   P0AA77
- EnsemblBacteria:   EBESCT00000042113
- GeneID:   1040044
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c4612
- GeneTree:   EBGT00050000008818
- HOGENOM:   HBG338043
- OMA:   THTRDPP
- ProtClustDB:   CLSK894831
- InterPro:   IPR004744
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- TIGRFAMs:   TIGR00881
- TIGRFAMs:   TIGR00893

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 47077; Mature: 47077

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1dccc650)-; HASH(0x1d2cea50)-; HASH(0x1dd369b0)-; HASH(0x1d53939c)-; HASH(0x1d544838)-; HASH(0x1cc0ef2c)-; HASH(0x1dc1ab88)-; HASH(0x1dd26334)-; HASH(0x1dcc4ac4)-; HASH(0x1c7f0550)-; HASH(0x1d9de928)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
AWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAP
HHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIG
CCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHH
IIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHR
HHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
KLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLVRKGFSLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
VSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYI
HHHCCCHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLVGDVKRVG
HHHHHHHHCH
>Mature Secondary Structure
MDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
AWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAP
HHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIG
CCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHH
IIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHR
HHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
KLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLVRKGFSLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
VSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYI
HHHCCCHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLVGDVKRVG
HHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157