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The map label for this gene is prlC

Identifier: 218697204

GI number: 218697204

Start: 4007948

End: 4009990

Strand: Reverse

Name: prlC

Synonym: EC55989_3936

Alternate gene names: 218697204

Gene position: 4009990-4007948 (Counterclockwise)

Preceding gene: 218697207

Following gene: 218697203

Centisome position: 77.79

GC content: 55.36

Gene sequence:

>2043_bases
ATGACGAATCCGTTACTGACTCCCTTTGAATTGCCTCCGTTTTCTAAAATTCTCCCGGAACATGTCGTTCCAGCCGTGAC
TAAGGCGCTGAACGACTGCCGCGAAAATGTGGAGCGCGTAGTAGCGCAAGGAGCACCGTACACCTGGGAAAATCTCTGCC
AGCCGTTGGCGGAAGTGGACGATGTGCTGGGGCGTATCTTCTCCCCGGTCAGCCACCTGAACTCGGTGAAAAATAGCCCG
GAACTGCGTGAAGCGTACGAACAAACCCTGCCGCTGCTGTCGGAATACAGCACCTGGGTAGGGCAACATGAAGGGCTGTA
TAAAGCGTATCGCGACCTGCGCGATGGCGATCATTACGCCACGCTGAACACGGCTCAGAAAAAAGCGGTTGATAACGCAC
TGCGCGACTTCGAACTCTCTGGCATCGGTCTGCCAATAGAGAAACAACAACGCTACGGTGAGATTGCCACTCGTCTTTCC
GAGCTGGGCAACCAGTACAGCAACAACGTCCTCGATGCGACGATGGGCTGGACCAAACTCGTTACCGACGAAGCGGAGCT
GGCGGGGATGCCTGAAAGCGCGCTGGCTGCGGCAAAAGCCCAGGCCGAAGCGAAAGAGCTGGAAGGCTACCTGCTGACGC
TGGATATCCCAAGCTACCTGCCGGTAATGACCTACTGCGACAACCAGGCCTTGCGTGAAGAGATGTATCGCGCTTACAGC
ACCCGCGCCTCCGATCAAGGCCCGAACGCCGGTAAATGGGATAACAGCAAGGTGATGGAAGAGATCCTCGCTCTGCGTCA
CGAACTGGCGCAACTGCTGGGCTTTGAAAACTACGCCTTTAAATCCCTTGCCACTAAAATGGCAGAAAACCCGCAGCAGG
TGCTGGATTTCTTAACCGATCTGGCAAAACGCGCGCGTCCGCAAGGCGAAAAAGAGCTGGCACAACTGCGCGCCTTCGCC
AAAGCGGAATTTGGCGTCGATGAGTTGCAGCCGTGGGATATCGCGTACTACAGCGAAAAACAAAAACAGCACCTCTACAG
CATCAGCGACGAGCAGCTGCGTCCGTACTTCCCAGAAAACAAAGCGGTTAACGGCCTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACCGCTAAAGAGCGTAAAGATGTTGATGTCTGGCATCCGGATGTACGTTTCTTCGAACTGTATGACGAAAAT
AACGAACTGCGCGGCAGCTTCTACCTCGATCTGTATGCCCGTGAAAACAAGCGCGGCGGGGCGTGGATGGATGACTGCGT
AGGCCAGATGCGTAAAGCTGATGGTTCGCTGCAAAAACCGGTCGCGTATTTGACTTGTAACTTCAACCGCCCGGTAAATG
GTAAACCGGCGCTGTTCACTCACGACGAAGTGATCACCCTGTTCCACGAGTTCGGTCACGGCCTGCACCATATGCTGACC
CGCATCGAAACCGCTGGTGTTTCCGGTATCAGCGGTGTGCCGTGGGATGCGGTCGAACTGCCGAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCGTTTATCTCCGGTCACTATGAAACCGGCGAACCGCTGCCGAAAGAGTTGCTGG
ATAAAATGCTGGCGGCGAAGAACTACCAGGCGGCGCTGTTTATTCTGCGTCAGCTGGAGTTCGGCCTGTTTGATTTCCGC
CTTCATGCCGAGTTCCGCCCGGATCAGGGGGCAAAAATCCTCGAAACTCTGGCAGAAATCAAGAAACTGGTTGCCGTGGT
GCCATCTCCGTCCTGGGGCCGTTTCCCGCACGCTTTCAGCCATATTTTCGCCGGTGGTTATGCGGCAGGTTACTACAGCT
ACCTGTGGGCTGACGTACTGGCGGCAGATGCTTTCTCGCGCTTTGAGGAAGAGGGCATTTTCAACCGTGAAACCGGGCAG
TCGTTCCTCGACAACATTCTGAGCCGTGGCGGTTCAGAAGAGCCGATGGATCTGTTCAAACGCTTCCGTGGTCGTGAACC
GCAGCTGGATGCGATGCTGGAGCATTACGGCATTAAGGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTCATTGAAATTCACTACACTTAACCCCATGCTACACACATTATGTAAAGCGCCTGTTGAGCGCTTCCTTAACCT
CTTTAACCAGGACTGCGCGA

Downstream 100 bases:

>100_bases
TCATTCAGTGAAAATCTGCTTAATTGATGAAACAGGCGCCGGAGACGGCGCCTTATCTGTTCTGGCGGCCCGCTGGGGGC
TGGAGCACGATGAAGACAAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPIEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPIEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPIEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENN
ELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQS
FLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=31.5625, Blast_Score=316, Evalue=6e-86,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=31.4641744548287, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI156105687, Length=618, Percent_Identity=26.8608414239482, Blast_Score=203, Evalue=4e-52,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=99.8529411764706, Blast_Score=1408, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.4599708879185, Blast_Score=325, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI71999758, Length=574, Percent_Identity=25.7839721254355, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=637, Percent_Identity=23.861852433281, Blast_Score=136, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319793, Length=691, Percent_Identity=28.7988422575977, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6322715, Length=697, Percent_Identity=23.3859397417504, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356111, Length=560, Percent_Identity=30.1785714285714, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI20129717, Length=682, Percent_Identity=25.6598240469208, Blast_Score=191, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77153; Mature: 77022

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPIEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPIEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]