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The map label for this gene is silC

Identifier: 218697184

GI number: 218697184

Start: 3985219

End: 3986907

Strand: Reverse

Name: silC

Synonym: EC55989_3915

Alternate gene names: 218697184

Gene position: 3986907-3985219 (Counterclockwise)

Preceding gene: 218697189

Following gene: 218697183

Centisome position: 77.34

GC content: 49.5

Gene sequence:

>1689_bases
ATGATATCCGGTAAGACCATTATCAGCGTGATCCACTACGAACCCTGCCTCTGTAAGCCCTTTGCTGAGATATTCACCTG
TTTTAATTTCGTCTTCGACGATCAATATTTTCATCTTGCTCCCCGGCTGGCTGCTAATGTCATTCTATTGCGCCCACGAT
CGTTATCAACGGATTACAGCAAAAATGACAACATTGTCATTATCCTGTCACCCGGCAAACAGAGAGCGTTAGGTAAAGTA
CCCCTATCAATACTCTGGACTTCATTTGAACCATTTACCAGGTCTGCCTGGACGAGAAGCGTTATGTTCAAATTAAAATT
ACTCAGCATTAGCACGATATTCATCCTGGCAGGCTGCGTGTCGCTTGCGCCTGAATATCAGCGGCCCGCAGCACCGGTAC
CCCAGCAGTTTTCACTGTCCCATAACAGCCTGACGCCAGCGGTAAATGGCTATCAGGATACGGGCTGGCGTAACTTTTTT
GTCGATCCCCAGGTTACCCGGTTGATCGGTGAAGCTCTGACTAATAACCGTGATTTGAGAATGGCTGCCCTGAAGGTTGA
AGAGGCCCGAGCCCAGTTCAACGTCACGGATGCAGATCGTTATCCCCAGCTGAATGCCTCATCCGGGATAACATACAGCG
GTGGTCTGAAAGGTGACAAGCCGACCACACAGGAGTACGACGCGAGACTGGAGCTCAGCTATGAGCTCGATTTTTTCGGC
AAACTTAAGAACATGAGTGATGCTGATCGCCAGAACTACTTTGCCAGCGAAGAAGCCCGTCGGGCCGTACACATCCTGCT
GGTATCCAACGTTTCACAAAGCTATTTCAGCCAGCAACTGGCGTACGAACAACTTCGTATTGCGCGGGAAACGCTGAAAA
ATTATCAACAGTCCTATGCTTTCGTTGAGCAGCAGCTCGTGACCGGGAGTACGAACGTTCTGGCACTTGAACAGGCGCGA
GGACAAATCGAAAGTACCCGCGCCGAAATAGCCAAACGAGAAGGCGATCTGGCTCAGGCAAACAATGCCCTGCAACTGGT
GCTGGGAACGTACCGCGCACTTCCGTCAGAAAAAGGGATGAAAGGCGGGGAGATAGCCCCAGTAAAATTGCCACCAAATC
TGTCTTCACAAATTTTGCTGCAGCGACCGGATATTATGGAAGCGGAATATCAGCTGAAAGCGGCTGATGCCAATATTGGC
GCAGCGCGAGCGGCCTTTTTCCCCTCAATTACCCTGACCAGTGGTCTTTCCGCAAGCAGTACGGAGCTGTCCAGCCTGTT
TACGTCAGGAAGTGGAATGTGGAATTTTATCCCTAAAATTGAAATTCCTATATTTAATGCTGGCAGGAATAAAGCCAATC
TGAAGCTGGCTGAAATTCGCCAGCAACAGTCGGTGGTTAATTACGAACAAAAAATTCAGTCAGCCTTTAAGGATGTTTCC
GACACGCTTGCGCTGCGCGACAGCCTTAGCCAGCAACTTGAGTCACAGCAGCGTTATCTTGATTCACTTCAGATAACTCT
CCAGCGTGCCAGAGGATTGTATGCAAGTGGTGCTGTCAGTTACATCGAAGTGCTGGATGCAGAACGTTCCCTCTTCGCTA
CCCAGCAAACCATTCTCGATCTTACCTATTCCCGGCAGGTTAACGAAATTAATCTGTTTACCGCGCTGGGTGGCGGTTGG
GTAGAGTAA

Upstream 100 bases:

>100_bases
CCTTTCCGGCAGTGCGCAGCATGCGGATGATATCCCAGCCGTTCACATCAGGTAGCATGATATCCAGAATGACTAAATCA
TACTCGGCTGTCATGGCGAG

Downstream 100 bases:

>100_bases
ATTTATTTAATTAATCAGGAAATTAAAATGCGTAATTCACTTAAAGCCGTTTTATTTGGTGCCTTCTCTGTCATGTTTTC
TGCCGGTCTTCATGCTGAAA

Product: copper/silver efflux system outer membrane protein CusC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MISGKTIISVIHYEPCLCKPFAEIFTCFNFVFDDQYFHLAPRLAANVILLRPRSLSTDYSKNDNIVIILSPGKQRALGKV
PLSILWTSFEPFTRSAWTRSVMFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFF
VDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFG
KLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQAR
GQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIG
AARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS
DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW
VE

Sequences:

>Translated_562_residues
MISGKTIISVIHYEPCLCKPFAEIFTCFNFVFDDQYFHLAPRLAANVILLRPRSLSTDYSKNDNIVIILSPGKQRALGKV
PLSILWTSFEPFTRSAWTRSVMFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFF
VDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFG
KLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQAR
GQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIG
AARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS
DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW
VE
>Mature_562_residues
MISGKTIISVIHYEPCLCKPFAEIFTCFNFVFDDQYFHLAPRLAANVILLRPRSLSTDYSKNDNIVIILSPGKQRALGKV
PLSILWTSFEPFTRSAWTRSVMFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFF
VDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFG
KLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQAR
GQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIG
AARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS
DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGW
VE

Specific function: Component of the sil cation-efflux system that confers resistance to silver. May be part of a three-component cation/proton antiporter [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=458, Percent_Identity=71.8340611353712, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI2367348, Length=481, Percent_Identity=24.7401247401247, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 62654; Mature: 62654

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISGKTIISVIHYEPCLCKPFAEIFTCFNFVFDDQYFHLAPRLAANVILLRPRSLSTDYS
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCCCCC
KNDNIVIILSPGKQRALGKVPLSILWTSFEPFTRSAWTRSVMFKLKLLSISTIFILAGCV
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLR
HHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCEE
MAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFG
EEEEEHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEHHHH
KLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYA
HHCCCCCHHHHHCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGM
HHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCCCCC
KGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASS
CCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHCCCEEEECCCCCCH
TELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS
HHHHHHHHCCCCCEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
LTYSRQVNEINLFTALGGGWVE
HHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MISGKTIISVIHYEPCLCKPFAEIFTCFNFVFDDQYFHLAPRLAANVILLRPRSLSTDYS
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCCCCC
KNDNIVIILSPGKQRALGKVPLSILWTSFEPFTRSAWTRSVMFKLKLLSISTIFILAGCV
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLR
HHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCEE
MAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFG
EEEEEHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEHHHH
KLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYA
HHCCCCCHHHHHCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGM
HHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCCCCC
KGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASS
CCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHCCCEEEECCCCCCH
TELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVS
HHHHHHHHCCCCCEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
LTYSRQVNEINLFTALGGGWVE
HHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]