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The map label for this gene is envZ

Identifier: 218697087

GI number: 218697087

Start: 3869845

End: 3871197

Strand: Reverse

Name: envZ

Synonym: EC55989_3812

Alternate gene names: 218697087

Gene position: 3871197-3869845 (Counterclockwise)

Preceding gene: 218697088

Following gene: 218697083

Centisome position: 75.1

GC content: 56.91

Gene sequence:

>1353_bases
ATGAGGCGATTGCGCTTCTCGCCACGAAGTTCATTTGCCCGTACGTTATTGCTCATCGTCACCTTGCTGTTCGCCAGCCT
GGTGACGACTTATCTGGTGGTGCTGAACTTCGCGATTTTGCCGAGCCTCCAGCAGTTTAATAAAGTCCTCGCGTACGAAG
TGCGTATGTTGATGACCGACAAACTGCAACTGGAGGACGGCACGCAGTTGGTTGTGCCTCCCGCTTTCCGTCGGGAGATC
TACCGTGAGCTGGGGATCTCTCTCTACTCCAACGAGGCTGCCGAAGAGGCAGGTCTGCGTTGGGCGCAACACTATGAATT
CTTAAGCCATCAGATGGCACAGCAACTGGGCGGCCCGACGGAAGTGCGCGTTGAGGTCAACAAAAGTTCGCCTGTCGTCT
GGCTGAAAACCTGGCTGTCGCCCAATATCTGGGTACGCGTGCCGCTGACCGAAATTCATCAGGGCGATTTCTCTCCGCTG
TTCCGCTATACGCTGGCGATTATGCTATTGGCGATAGGCGGGGCGTGGCTGTTTATTCGTATCCAGAACCGACCGTTGGT
CGATCTCGAACACGCAGCCTTGCAGGTTGGTAAAGGGATTATTCCGCCGCCGCTGCGTGAGTATGGCGCTTCGGAGGTGC
GTTCCGTTACCCGTGCCTTTAACCATATGGCGGCTGGTGTTAAGCAACTGGCGGATGACCGCACGCTGCTGATGGCGGGG
GTAAGTCACGACTTGCGCACGCCGCTGACGCGTATTCGCCTGGCGACTGAGATGATGAGCGAGCAGGATGGCTATCTGGC
AGAATCGATCAATAAAGATATCGAAGAGTGCAACGCCATCATTGAGCAGTTTATCGACTACCTGCGCACCGGGCAGGAGA
TGCCGATGGAAATGGCGGATCTTAATGCAGTACTCGGTGAGGTGATTGCTGCCGAAAGTGGCTATGAGCGGGAAATTGAA
ACCGCGCTTTACCCCGGCAGCATTGAAGTGAAAATGCACCCGCTGTCGATCAAACGCGCGGTGGCGAATATGGTGGTCAA
CGCCGCCCGTTATGGCAATGGCTGGATCAAAGTCAGCAGCGGAACGGAGCCGAATCGCGCCTGGTTCCAGGTGGAAGATG
ACGGTCCGGGAATTGCACCGGAACAGCGTAAGCACCTGTTCCAGCCATTTGTCCGCGGCGACAGTGCGCGCACCATTAGC
GGCACGGGGCTAGGGCTGGCAATTGTGCAGCGCATCGTGGATAACCATAACGGGATGCTGGAGCTTGGCACCAGCGAGCG
GGGCGGGCTTTCCATTCGTGCCTGGCTGCCTGTTCCGGTAACGCGGGCGCAGGGCACGATAAAAGAAGGGTAA

Upstream 100 bases:

>100_bases
CGCGTCTGCGCCGCATGGTAGAAGAAGATCCAGCGCATCCGCGTTACATTCAGACCGTTTGGGGCCTGGGCTACGTCTTT
GTACCGGACGGCTCTAAAGC

Downstream 100 bases:

>100_bases
ATAAACTGGAGGCGAAGGTGCCTCCTGTTTTATATTGATTTCAATTGATTGATAATGAAAGGATTCGCTTGCAAAAGCAG
GAGCAATTTTCGAGGTGCTC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTIKEG

Sequences:

>Translated_450_residues
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTIKEG
>Mature_450_residues
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIE
TALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTIS
GTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTIKEG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=450, Percent_Identity=99.7777777777778, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=32.4909747292419, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=30.2919708029197, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=26.605504587156, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=31.3084112149533, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=27.5618374558304, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=27.9352226720648, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789403, Length=248, Percent_Identity=27.0161290322581, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=28.9256198347107, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=26.1648745519713, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=23.5059760956175, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=26.2931034482759, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=27.6497695852535, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50347; Mature: 50347

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCCHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGML
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCEE
ELGTSERGGLSIRAWLPVPVTRAQGTIKEG
EECCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCCHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGML
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCEE
ELGTSERGGLSIRAWLPVPVTRAQGTIKEG
EECCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]