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The map label for this gene is xdhA

Identifier: 218696462

GI number: 218696462

Start: 3224486

End: 3226744

Strand: Direct

Name: xdhA

Synonym: EC55989_3153

Alternate gene names: 218696462

Gene position: 3224486-3226744 (Clockwise)

Preceding gene: 218696457

Following gene: 218696463

Centisome position: 62.55

GC content: 52.99

Gene sequence:

>2259_bases
ATGCGCGTCGATGCCATTGCTAAGGTCACCGGGCGGGCACGATATACTGACGATTATGTTATGGCGGGCATGTGTTATGC
GAAATATGTACGTAGCCCTATCGCACATGGTTATGCCGTAAGTATTAATGATGAACAAGCCAGAAGTTTGCCGGGCGTAC
TGGCGATTTTTACCTGGGAAGATGTGCCTGATATTCCATTTGCTACTGCTGGGCATGCCTGGACACTTGACGAAAACAAG
CGCGATACCGCCGATCGCGCACTGCTAACTCGCCATGTTCGTCATCATGGTGACGCCGTTGCCATCGTCGTGGCCCGCGA
TGAACTCACGGCAGAAAAAGCGGCGCAATTGGTCAGCATTGAGTGGCAAGAATTACCCGTTATCACCACGCCAGAAGCGG
CGCTGGCAGAAGACGCTGCACCAATCCATAACGGTGGCAATTTACTGAAACAAAGCACGATGTCGACGGGTAATGTCCAA
CAAACAATCGATGCCGCCGACTACCAGGTACAGGGGCACTATCAGACCCCCGTTATTCAACATTGTCACATGGAAAGCGT
AACATCGCTGGCGTGGATGGAGGATGACTCGCGAATTACCATCGTTTCCAGCACCCAGATCCCGCACATTGTTCGCCGCG
TGGTTGGTCAGGCGCTGGATATTCCCTGGTCATGCGTACGAGTCATCAAACCGTTTGTCGGTGGCGGTTTTGGTAATAAA
CAGGATGTACTGGAAGAGCCAATGGCGGCATTCCTGACCAGCAAGCTTGGCGGCATTCCGGTGAAAGTTTCCCTTAGCCG
TGAAGAGTGTTTCCTCGCAACCCGTACCCGCCACGCTTTTACCATTGACGGGCAAATGGGCGTGAACCGCGACGGAACAT
TGAAAGGTTATAGTCTGGATGTTCTGTCTAACACCGGCGCTTATGCATCTCACGGGCACTCCATCGCTTCTGCGGGGGGG
AATAAAGTCGCTTACCTTTATCCTCGTTGTGCCTACGCTTACAGTTCAAAGACCTGCTATACCAACCTCCCCTCGGCTGG
TGCGATGCGTGGTTATGGCGCGCCACAAGTCGTATTTGCCGTTGAGTCTATGCTTGATGACGCCGCGACAGCGTTAGGTA
TTGATCCTGTTGAAATTCGTTTACGCAACGCCGCCCGCGAAGGAGATGCTAATCCGCTCACGGGCAAACGTATTTACAGC
GCAGGGTTGCCGGAGTGTCTTGAAAAAGGCCGGAAAATCTTTGAATGGGAAAAACGCCGTGCAGAATGCCAGAACCAGCA
AGGCAATTTGCGCCGCGGCGTTGGCGTCGCCTGTTTTAGCTACACCTCTAACACCTGGCCTGTCGGCGTAGAAATAGCAG
GCGCGCGCCTTCTGATGAATCAGGATGGAACCATCAACGTGCAAAGCGGCGCGACGGAAATCGGTCAGGGTGCCGACACC
GTCTTCTCGCAAATGGTGGCAGAAACCGTGGGGGTTCCGGTCAGCGACGTTCGCGTTATTTCAACTCAAGATACCGACGT
TACGCCGTTCGATCCCGGCGCATTTGCCTCACGCCAGAGCTATGTTGCCGCGCCTGCGCTGCGCAGTGCGGCACTATTAT
TAAAAGAGAAAATCATCGCTCACGCCGCAGTCATGCTACATCAGTCAGCGATGAATCTGACCCTGATAAAAGGCCATATC
GTGCTGGTTGAACGACCGGAAGAGCCGTTAATGTCGTTAAAAGATTTGGCGATGGACGCTTTCTACCACCCTGAACGCGG
CGGGCAGCTCTCTGCTGAAAGCTCCATCAAAACCACCACTAACCCACCGGCGTTTGGCTGTACCTTTGTTGATCTGACGG
TCGATATTGCGCTGTGCAAAGTCACCATCAACCGCATCCTCAACGTTCATGATTCAGGGCATATTCTTAATCCACTGCTG
GCAGAAGGTCAGGTACACGGCGGAATGGGAATGGGCATTGGCTGGGCGCTATTTGAAGAGATGATCATCGATGCTAAAAG
CGGCGTGGTCCGTAACCCCAATCTGCTGGATTACAAAATGCCGACCATGCCGGATCTGCCACAACTGGAAAGCGCGTTCG
TCGAAATCAATGAGCCGCAATCCGCATACGGACATAAGTCACTGGGTGAGCCACCAATAATTCCTGTTGCCGCTGCTATT
CGTAACGCGGTGAAGATGGCTACCGGTGTTGCAATCAATACACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCA
TCTGGCAGGATTGATTTGA

Upstream 100 bases:

>100_bases
CTTGCCTGCTTAGACTAAATCTTTGCCATAAGAACCAAATGTTCAAATCGAGGGGATTTCTATGGAAGCGCGGGAAGCAA
CCGCTACGGGTGAATCATGC

Downstream 100 bases:

>100_bases
GGATAACATCATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAACCTGCTGGCTGACAACC
CGCAGGCCAAACTGCTCGCC

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Sequences:

>Translated_752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
>Mature_752_residues
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPFATAGHAWTLDENK
RDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQ
QTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGAYASHGHSIASAGG
NKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYS
AGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHI
VLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLL
AEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=789, Percent_Identity=26.489226869455, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=24.738219895288, Blast_Score=168, Evalue=2e-41,
Organism=Escherichia coli, GI1789230, Length=752, Percent_Identity=100, Blast_Score=1559, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=793, Percent_Identity=29.8865069356873, Blast_Score=310, Evalue=3e-85,
Organism=Escherichia coli, GI1786478, Length=763, Percent_Identity=29.0956749672346, Blast_Score=223, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17540638, Length=766, Percent_Identity=26.8929503916449, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17539860, Length=729, Percent_Identity=23.4567901234568, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=23.5694822888283, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=26.1103633916555, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24647193, Length=769, Percent_Identity=24.1872561768531, Blast_Score=143, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24647199, Length=749, Percent_Identity=23.3644859813084, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24647201, Length=754, Percent_Identity=23.6074270557029, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647195, Length=713, Percent_Identity=21.4586255259467, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647197, Length=709, Percent_Identity=21.5796897038082, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 81322; Mature: 81322

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWE
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEEEEEEEC
DVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSI
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHCHHHHHHEEEE
EWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQ
EHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHH
HCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
HHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCH
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLD
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEE
VLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFA
EECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCCCCCCCCCCHHHHH
VESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
AECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
HHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEECCCCCHHCCCHHH
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIA
HHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTT
HHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEE
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
MIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
HHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCCCCCCCCHHHHHHH
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
HHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWE
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEEEEEEEC
DVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSI
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHCHHHHHHEEEE
EWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQ
EHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHH
HCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVRVIKPFVGGGFGNK
HHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCH
QDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLD
HHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEE
VLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFA
EECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCCCCCCCCCCHHHHH
VESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECLEKGRKIFEWEKRR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
AECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINVQSGATEIGQGADT
HHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEECCCCCHHCCCHHH
VFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIA
HHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTT
HHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEE
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHH
MIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKSLGEPPIIPVAAAI
HHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCCCCCCCCHHHHHHH
RNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
HHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]