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The map label for this gene is pmrD

Identifier: 218695862

GI number: 218695862

Start: 2575295

End: 2575561

Strand: Reverse

Name: pmrD

Synonym: EC55989_2507

Alternate gene names: 218695862

Gene position: 2575561-2575295 (Counterclockwise)

Preceding gene: 218695863

Following gene: 218695854

Centisome position: 49.96

GC content: 46.82

Gene sequence:

>267_bases
ATGGAATGGCTGGTCAAAAAATCGTGCTGCAATAAACAAGATAACAGACATGTACTTATGCTCTGCGATGCTGGCGGCGC
GATAAAAATGATCGCCGAAGTGAAGAGTGACTTCGCCGTGAAAGTGGGGGATTTACTCTCGCCTTTGCAGAATGCGCTAT
ATTGTATTAATCGTGAAAAGCTGCATACGGTGAAAGTCCTCTCGGCAAGCAGTTATAGCCCCGATGAGTGGGAACGGCAG
TGTAAAGTGGCACGGAAAACTCAGTAA

Upstream 100 bases:

>100_bases
CGTTTCACTTCTCATTTCTGCCATTCCATTGCCGTTGATAAAGAGTTTATCTGTTAATCTGTAAATTGATGTGAAAACTC
TTAGCAAACAGGATAATGCA

Downstream 100 bases:

>100_bases
CGTTGTTTTGTCATGGGCAGGAAAATCAGCATCAACCCGCTCATAATACAGGCTACTCCCAGTAGTGCTTTCAGCGAAAA
AGTCCCTTCCCAGCCGGGAA

Product: polymyxin resistance protein B

Products: NA

Alternate protein names: BasR post-transcriptional activator; Polymyxin resistance protein pmrD [H]

Number of amino acids: Translated: 88; Mature: 88

Protein sequence:

>88_residues
MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDEWERQ
CKVARKTQ

Sequences:

>Translated_88_residues
MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDEWERQ
CKVARKTQ
>Mature_88_residues
MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDEWERQ
CKVARKTQ

Specific function: Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pmrD family [H]

Homologues:

Organism=Escherichia coli, GI87082076, Length=88, Percent_Identity=98.8636363636364, Blast_Score=181, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020146
- ProDom:   PD028730 [H]

Pfam domain/function: PF11183 PmrD [H]

EC number: NA

Molecular weight: Translated: 9970; Mature: 9970

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREK
CCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC
LHTVKVLSASSYSPDEWERQCKVARKTQ
HHEEEEEECCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREK
CCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC
LHTVKVLSASSYSPDEWERQCKVARKTQ
HHEEEEEECCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626063; 9205837; 9278503 [H]