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The map label for this gene is yeiA

Identifier: 218695758

GI number: 218695758

Start: 2450920

End: 2452125

Strand: Direct

Name: yeiA

Synonym: EC55989_2397

Alternate gene names: 218695758

Gene position: 2450920-2452125 (Clockwise)

Preceding gene: 218695757

Following gene: 218695763

Centisome position: 47.55

GC content: 51.58

Gene sequence:

>1206_bases
TTGCGGCGTGAAGTTTCCCAACCCGTTCTGCCTCTCTTCTTCCCTGTAGGCAACTGCTATGAGATGTGTGCCAAAGCCTA
CGACACAGGTTGGGGCGGCGTGGTGTTTAAAACGATCGGCTTTTTTATCGCCAACGAAGTCTCGCCGCGTTTTGATCATC
TGGTGAAAGAAGATACCGGTTTTATCGGCTTCAAAAATATGGAGCAGATTGCTGAACATCCGTTGGAAGAGAATCTGGCC
GCCCTGCGTCAGCTGAAGGAAGATTACCCGGACAAAGTATTGATCGCTTCGATCATGGGGGAAAATGAGCAGCAATGGGA
GGAGCTGGCGCGCCTGGTGCAAGAAGCTGGCGCGGATATGATCGAGTGTAACTTCTCCTGTCCGCAAATGACTTCTCATG
CGATGGGTAGCGATGTCGGGCAAAGCCCGGAGCTGGTAGAAAAATATTGTCGGGCAGTGAAACGGGGTTCCACGCTGCCA
ATGCTGGCGAAGATGACGCCGAATATCGGTGATATGTGCGAAGTGGCGCTGGCGGCGAAGCGCGGCGGCGCAGATGGCAT
TGCGGCGATTAACACCGTTAAATCCATCACCAATATCGATCTTAATCAGAAAATCGGTATGCCGATCGTTAACGGAAAAT
CGAGTATTTCCGGATATTCCGGTAAAGCGGTAAAACCGATCGCCCTGCGCTTCATTCAGCAGATGCGCACCCATCCAGAA
CTGCGCGATTTCCCAATCAGCGGTATCGGCGGCATTGAAACCTGGGAGGATGCGGCTGAGTTTTTATTGCTCGGCGCAGC
AACGTTACAGGTGACCACCGGCATCATGCAGTACGGGTATCGGATAGTGGAAGATATGGCAAGCGGGTTGTCGCATTATC
TCGCCGATCAGGGATTTGATTCGCTGCAGGAGATGGTAGGTCTGGCGAATAACAATATTGTCCCGGCGGAAGATTTAGAC
CGCAGTTATATTGTCTATCCCCGTATCAATCTTGATAAATGTGTTGGCTGTGGACGCTGTTATATTTCCTGTTACGACGG
CGGTCACCAGGCGATGGAATGGAGCGAGAAAACCCGCACACCGCATTGTAATACCGAGAAATGTGTGGGTTGTCTGCTTT
GTGGTCACGTCTGCCCGGTGGGTTGTATTGAGCTCGGGGAAGTGAAGTTTAAGAAAGGCGAGAAAGAACACCCGGTAACG
TTGTAA

Upstream 100 bases:

>100_bases
GTGGTCTATGCCGTGAAAACCGGGAAAGAAGCCGCCGAGGCGATTCATCACTATTTAGAGGGAGCTTGCTCATGTTAACG
AAAGATCTTTCGATTACTTT

Downstream 100 bases:

>100_bases
AACCAGAGACGCATCCGGCATTTGGCACCGATTGCCGGATGCAGCGCATCCGGCAATATCCACAATCACATCACTTCTTA
CGCGCGTATTTCAGTGAATC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRREVSQPVLPLFFPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLA
ALRQLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP
MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE
LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD
RSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVT
L

Sequences:

>Translated_401_residues
MRREVSQPVLPLFFPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLA
ALRQLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP
MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE
LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD
RSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVT
L
>Mature_401_residues
MRREVSQPVLPLFFPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLA
ALRQLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP
MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE
LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD
RSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVT
L

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=301, Percent_Identity=35.8803986710963, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI87082059, Length=387, Percent_Identity=99.7416020671835, Blast_Score=805, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=297, Percent_Identity=39.0572390572391, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322633, Length=241, Percent_Identity=27.8008298755187, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640763, Length=295, Percent_Identity=37.9661016949153, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI18858217, Length=295, Percent_Identity=37.9661016949153, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 44124; Mature: 44124

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRREVSQPVLPLFFPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTG
CCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FIGFKNMEQIAEHPLEENLAALRQLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADM
CCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCCE
IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAK
EEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHH
RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRT
HHHHHHHHCCCCCCCHHHCCCCEEEEECCCHHHHCCCCCEEEEEECCCHHHHHHHHHCCC
PHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL
CCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRREVSQPVLPLFFPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTG
CCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FIGFKNMEQIAEHPLEENLAALRQLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADM
CCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCCE
IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAK
EEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHH
RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRT
HHHHHHHHCCCCCCCHHHCCCCEEEEECCCHHHHCCCCCEEEEEECCCHHHHHHHHHCCC
PHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL
CCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]